SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ty6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV
(Bacillus
anthracis) 		5 / 11 VAL A  12
ALA A 136
ILE A 163
ALA A 142
ASP A 166
 None
 1.22A 2admB-3ty6A:
undetectable		 2admB-3ty6A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV
(Bacillus
anthracis) 		5 / 11 GLY A 140
ALA A 139
ILE A 167
GLY A 133
ILE A 163
 None
 1.03A 2b60B-3ty6A:
undetectable		 2b60B-3ty6A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV
(Bacillus
anthracis) 		4 / 7 LEU A 137
GLY A 132
THR A 171
ILE A 175
 None
 0.93A 2bdmA-3ty6A:
undetectable		 2bdmA-3ty6A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV
(Bacillus
anthracis) 		4 / 8 THR A   8
ASP A  23
TYR A 170
CYH A 168
 None
 1.22A 2xz5A-3ty6A:
undetectable
2xz5C-3ty6A:
undetectable		 2xz5A-3ty6A:
19.00
2xz5C-3ty6A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV
(Bacillus
anthracis) 		5 / 12 LEU A 161
GLY A 130
GLU A  99
ALA A 100
ALA A   6
 None
 1.20A 4pclA-3ty6A:
undetectable		 4pclA-3ty6A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV
(Bacillus
anthracis) 		5 / 11 THR A 171
ALA A  21
GLY A 132
GLY A 133
ALA A 136
 None
 1.04A 4qvlY-3ty6A:
10.2
4qvlZ-3ty6A:
6.1		 4qvlY-3ty6A:
27.14
4qvlZ-3ty6A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV
(Bacillus
anthracis) 		5 / 9 THR A 171
ALA A  21
GLY A 132
GLY A 133
ALA A 136
 None
 1.04A 4qvmK-3ty6A:
19.8
4qvmL-3ty6A:
17.5		 4qvmK-3ty6A:
27.14
4qvmL-3ty6A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV
(Bacillus
anthracis) 		5 / 10 THR A 171
ALA A  21
GLY A 132
GLY A 133
ALA A 136
 None
 1.04A 4qvmY-3ty6A:
10.2
4qvmZ-3ty6A:
6.1		 4qvmY-3ty6A:
27.14
4qvmZ-3ty6A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV
(Bacillus
anthracis) 		5 / 10 THR A 171
ALA A  21
GLY A 132
GLY A 133
ALA A 136
 None
 1.00A 4qvpK-3ty6A:
19.8
4qvpL-3ty6A:
17.3		 4qvpK-3ty6A:
27.14
4qvpL-3ty6A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV
(Bacillus
anthracis) 		5 / 10 THR A 171
ALA A  21
GLY A 132
GLY A 133
ALA A 136
 None
 1.00A 4qvpY-3ty6A:
10.2
4qvpZ-3ty6A:
17.4		 4qvpY-3ty6A:
27.14
4qvpZ-3ty6A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV
(Bacillus
anthracis) 		5 / 11 THR A 171
ALA A  21
GLY A 132
GLY A 133
ALA A 136
 None
 1.01A 4qw1K-3ty6A:
20.0
4qw1L-3ty6A:
17.5		 4qw1K-3ty6A:
27.36
4qw1L-3ty6A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV
(Bacillus
anthracis) 		5 / 10 THR A 171
ALA A  21
GLY A 132
GLY A 133
ALA A 136
 None
 1.01A 4qw1Y-3ty6A:
10.2
4qw1Z-3ty6A:
17.4		 4qw1Y-3ty6A:
27.36
4qw1Z-3ty6A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV
(Bacillus
anthracis) 		5 / 10 THR A 171
ALA A  21
GLY A 132
GLY A 133
ALA A 136
 None
 1.05A 4qw3K-3ty6A:
19.7
4qw3L-3ty6A:
17.4		 4qw3K-3ty6A:
27.14
4qw3L-3ty6A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV
(Bacillus
anthracis) 		5 / 10 THR A 171
ALA A  21
GLY A 132
GLY A 133
ALA A 136
 None
 1.05A 4qw3Y-3ty6A:
10.0
4qw3Z-3ty6A:
17.3		 4qw3Y-3ty6A:
27.14
4qw3Z-3ty6A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV
(Bacillus
anthracis) 		4 / 8 ALA A 139
ALA A 159
ALA A 147
ALA A 142
 None
 0.73A 4twdF-3ty6A:
undetectable
4twdG-3ty6A:
undetectable
4twdH-3ty6A:
undetectable
4twdI-3ty6A:
undetectable
4twdJ-3ty6A:
undetectable		 4twdF-3ty6A:
21.00
4twdG-3ty6A:
21.00
4twdH-3ty6A:
21.00
4twdI-3ty6A:
21.00
4twdJ-3ty6A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV
(Bacillus
anthracis) 		4 / 8 ALA A 147
ALA A 142
ALA A 139
ALA A 159
 None
 0.76A 4twdF-3ty6A:
undetectable
4twdG-3ty6A:
undetectable
4twdH-3ty6A:
undetectable
4twdI-3ty6A:
undetectable
4twdJ-3ty6A:
undetectable		 4twdF-3ty6A:
21.00
4twdG-3ty6A:
21.00
4twdH-3ty6A:
21.00
4twdI-3ty6A:
21.00
4twdJ-3ty6A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV
(Bacillus
anthracis) 		5 / 11 THR A 171
ALA A  21
GLY A 132
GLY A 133
ALA A 136
 None
 1.03A 5bxnK-3ty6A:
20.0
5bxnL-3ty6A:
17.3		 5bxnK-3ty6A:
27.14
5bxnL-3ty6A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV
(Bacillus
anthracis) 		5 / 11 THR A 171
ALA A  21
GLY A 132
GLY A 133
ALA A 136
 None
 1.03A 5bxnY-3ty6A:
10.2
5bxnZ-3ty6A:
17.5		 5bxnY-3ty6A:
27.14
5bxnZ-3ty6A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV
(Bacillus
anthracis) 		5 / 12 VAL A 177
ALA A  19
ILE A 156
GLN A 155
PHE A  10
 None
 1.33A 5hgcA-3ty6A:
undetectable		 5hgcA-3ty6A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV
(Bacillus
anthracis) 		6 / 12 VAL A  49
GLU A  17
ALA A  11
VAL A 104
LEU A 127
GLY A 125
 None
 1.41A 5igtA-3ty6A:
undetectable		 5igtA-3ty6A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV
(Bacillus
anthracis) 		5 / 12 GLU A  99
ASP A  59
ALA A   6
SER A 131
GLY A  29
 None
 1.28A 5syeB-3ty6A:
undetectable		 5syeB-3ty6A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV
(Bacillus
anthracis) 		4 / 6 ILE A 126
LEU A 143
VAL A  12
SER A 160
 None
 1.13A 6f6jA-3ty6A:
undetectable		 6f6jA-3ty6A:
undetectable