SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ty7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		4 / 7 LEU A 169
LEU A 142
SER A 220
THR A 222
 None
 0.72A 1dvxB-3ty7A:
undetectable		 1dvxB-3ty7A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		4 / 6 LEU A 169
LEU A 142
SER A 220
THR A 222
 None
 0.92A 1ictB-3ty7A:
undetectable		 1ictB-3ty7A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		4 / 7 LEU A 169
LEU A 142
SER A 220
THR A 222
 None
 0.75A 1ictD-3ty7A:
undetectable		 1ictD-3ty7A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		5 / 9 ASP A 256
LEU A 393
VAL A 411
ILE A 412
ILE A 260
 None
 1.24A 1q6iA-3ty7A:
undetectable		 1q6iA-3ty7A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		4 / 6 LEU A 169
LEU A 142
SER A 220
THR A 222
 None
 0.70A 1tyrA-3ty7A:
undetectable		 1tyrA-3ty7A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		4 / 5 PHE A 196
PHE A 186
PHE A 111
VAL A 167
 None
 1.15A 2lh6A-3ty7A:
2.0		 2lh6A-3ty7A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		4 / 7 TYR A 390
VAL A 411
ASP A 256
VAL A 258
 None
 1.03A 2qbnA-3ty7A:
undetectable		 2qbnA-3ty7A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		4 / 5 THR A 222
THR A 150
HIS A 103
LEU A  92
 None
 1.25A 2zj0A-3ty7A:
2.5		 2zj0A-3ty7A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		5 / 12 ASN A 391
ILE A 412
LYS A 414
ASP A 415
THR A 418
 None
 0.88A 3a25A-3ty7A:
4.7		 3a25A-3ty7A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		5 / 12 SER A 154
LEU A 157
THR A 222
THR A 144
ASN A 151
 None
 1.11A 3a35A-3ty7A:
undetectable		 3a35A-3ty7A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		5 / 12 SER A 154
LEU A 157
THR A 222
THR A 144
ASN A 151
 None
 1.04A 3a35B-3ty7A:
undetectable		 3a35B-3ty7A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		5 / 12 SER A 154
LEU A 157
THR A 222
THR A 144
ASN A 151
 None
 1.09A 3a3bA-3ty7A:
undetectable		 3a3bA-3ty7A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		4 / 5 THR A 222
THR A 150
HIS A 103
LEU A  92
 None
 1.18A 3ce6A-3ty7A:
4.0		 3ce6A-3ty7A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		4 / 5 THR A 222
THR A 150
HIS A 103
LEU A  92
 None
 1.20A 3ce6C-3ty7A:
2.2		 3ce6C-3ty7A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		4 / 6 LEU A 169
LEU A 142
SER A 220
THR A 222
 None
 0.78A 3cfqA-3ty7A:
undetectable		 3cfqA-3ty7A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		4 / 7 LEU A 169
LEU A 142
SER A 220
THR A 222
 None
 0.78A 3cfqA-3ty7A:
undetectable
3cfqB-3ty7A:
undetectable		 3cfqA-3ty7A:
13.74
3cfqB-3ty7A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		4 / 7 ALA A 396
VAL A 411
VAL A 422
LEU A 393
 None
 0.69A 3o14A-3ty7A:
undetectable		 3o14A-3ty7A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		4 / 5 GLY A  39
LYS A  38
GLU A  20
GLY A 205
 None
 1.05A 3onnA-3ty7A:
2.7		 3onnA-3ty7A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		4 / 7 LEU A 169
LEU A 142
SER A 220
THR A 222
 None
 0.73A 3ozkB-3ty7A:
undetectable		 3ozkB-3ty7A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		5 / 10 TYR A 359
ILE A 321
ASN A  26
ILE A 322
GLU A 174
 None
 1.29A 3u6tA-3ty7A:
undetectable		 3u6tA-3ty7A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		3 / 3 PHE A 464
SER A 243
SER A 220
 None
 0.86A 3ufgB-3ty7A:
undetectable		 3ufgB-3ty7A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		4 / 7 LEU A 169
LEU A 142
SER A 220
THR A 222
 None
 0.88A 4d7bA-3ty7A:
undetectable		 4d7bA-3ty7A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		5 / 12 ASP A 257
THR A 389
ILE A 412
VAL A 258
ILE A 260
 None
 1.43A 4eb6B-3ty7A:
undetectable
4eb6C-3ty7A:
undetectable		 4eb6B-3ty7A:
22.24
4eb6C-3ty7A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		4 / 8 LEU A 169
LEU A 142
SER A 220
THR A 222
 None
 0.74A 4ik7B-3ty7A:
undetectable		 4ik7B-3ty7A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		4 / 6 LEU A 169
LEU A 142
SER A 220
THR A 222
 None
 0.78A 4ikiB-3ty7A:
undetectable		 4ikiB-3ty7A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		4 / 7 LEU A 169
LEU A 142
SER A 220
THR A 222
 None
 0.79A 4ikjA-3ty7A:
undetectable
4ikjB-3ty7A:
undetectable		 4ikjA-3ty7A:
14.22
4ikjB-3ty7A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		4 / 7 LEU A 169
LEU A 142
SER A 220
THR A 222
 None
 0.80A 4ikkA-3ty7A:
undetectable
4ikkB-3ty7A:
undetectable		 4ikkA-3ty7A:
14.22
4ikkB-3ty7A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		4 / 7 LEU A 169
LEU A 142
SER A 220
THR A 222
 None
 0.77A 4iklA-3ty7A:
undetectable
4iklB-3ty7A:
undetectable		 4iklA-3ty7A:
14.22
4iklB-3ty7A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		4 / 8 LEU A 169
LEU A 142
SER A 220
THR A 222
 None
 0.80A 4iklA-3ty7A:
undetectable
4iklB-3ty7A:
undetectable		 4iklA-3ty7A:
14.22
4iklB-3ty7A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		5 / 12 SER A 154
LEU A 157
PHE A 186
TYR A  77
ASP A 187
 None
 1.30A 4j7xF-3ty7A:
3.5		 4j7xF-3ty7A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		5 / 12 SER A 154
LEU A 157
PHE A 186
TYR A  77
ASP A 187
 None
 1.37A 4j7xJ-3ty7A:
3.1		 4j7xJ-3ty7A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		4 / 5 TYR A 359
ILE A 321
ASN A  26
ILE A 322
 None
 1.06A 4jtpA-3ty7A:
undetectable		 4jtpA-3ty7A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		3 / 3 GLY A 319
PRO A 320
GLN A 277
 None
 0.37A 4oltB-3ty7A:
0.7		 4oltB-3ty7A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		3 / 3 GLY A 319
PRO A 320
GLN A 277
 None
 0.34A 4qwpB-3ty7A:
0.7		 4qwpB-3ty7A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		5 / 12 GLY A 269
PHE A 303
MET A 385
ALA A 264
GLN A 302
 None
 1.14A 4ubeA-3ty7A:
2.5		 4ubeA-3ty7A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		5 / 8 ALA A 160
VAL A 167
GLY A 164
ALA A 136
GLY A 138
 None
 1.26A 4zjzA-3ty7A:
2.5		 4zjzA-3ty7A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122
(Staphylococcus
aureus) 		4 / 8 GLY A 248
SER A 250
ASN A 147
VAL A 278
 None
 1.01A 6giqL-3ty7A:
undetectable
6giqP-3ty7A:
undetectable
6giqT-3ty7A:
undetectable		 6giqL-3ty7A:
22.94
6giqP-3ty7A:
18.45
6giqT-3ty7A:
9.74