SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tz6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 277
GLY A 314
GLY A 316
ALA A 273
LEU A 142
 None
 1.03A 1bx4A-3tz6A:
undetectable		 1bx4A-3tz6A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 9 ARG A 120
GLY A   6
ALA A 338
THR A  90
ILE A   5
 SO4  A 408 (-2.6A)
None
None
None
None
 1.43A 1c9sA-3tz6A:
undetectable
1c9sB-3tz6A:
undetectable		 1c9sA-3tz6A:
12.54
1c9sB-3tz6A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 ARG A 120
GLY A   6
ALA A 338
THR A  90
ILE A   5
 SO4  A 408 (-2.6A)
None
None
None
None
 1.43A 1c9sG-3tz6A:
undetectable
1c9sH-3tz6A:
undetectable		 1c9sG-3tz6A:
12.54
1c9sH-3tz6A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 ARG A 120
GLY A   6
ALA A 338
THR A  90
ILE A   5
 SO4  A 408 (-2.6A)
None
None
None
None
 1.40A 1gtfC-3tz6A:
undetectable
1gtfD-3tz6A:
undetectable		 1gtfC-3tz6A:
12.54
1gtfD-3tz6A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 9 ARG A 120
GLY A   6
ALA A 338
THR A  90
ILE A   5
 SO4  A 408 (-2.6A)
None
None
None
None
 1.42A 1gtfF-3tz6A:
undetectable
1gtfG-3tz6A:
undetectable		 1gtfF-3tz6A:
12.54
1gtfG-3tz6A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 ARG A 120
GLY A   6
ALA A 338
THR A  90
ILE A   5
 SO4  A 408 (-2.6A)
None
None
None
None
 1.41A 1gtfG-3tz6A:
undetectable
1gtfH-3tz6A:
0.1		 1gtfG-3tz6A:
12.54
1gtfH-3tz6A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 6 PHE A  84
ILE A   7
ALA A  57
MET A  76
 None
 1.24A 1hk2A-3tz6A:
undetectable		 1hk2A-3tz6A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  21
LEU A 332
THR A 334
ILE A  92
ILE A   5
 None
 1.40A 1hzeA-3tz6A:
undetectable
1hzeB-3tz6A:
undetectable		 1hzeA-3tz6A:
16.56
1hzeB-3tz6A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  21
LEU A 332
THR A 334
ILE A  92
ILE A   7
 None
 1.50A 1hzeA-3tz6A:
undetectable
1hzeB-3tz6A:
undetectable		 1hzeA-3tz6A:
16.56
1hzeB-3tz6A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 9 ILE A   5
LEU A  21
LEU A 332
THR A 334
ILE A  92
 None
 1.40A 1hzeA-3tz6A:
undetectable
1hzeB-3tz6A:
undetectable		 1hzeA-3tz6A:
16.56
1hzeB-3tz6A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 9 ILE A   7
LEU A  21
LEU A 332
THR A 334
ILE A  92
 None
 1.50A 1hzeA-3tz6A:
undetectable
1hzeB-3tz6A:
undetectable		 1hzeA-3tz6A:
16.56
1hzeB-3tz6A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A  21
LEU A 332
THR A 334
ILE A  92
ILE A   5
 None
 1.32A 1i18A-3tz6A:
undetectable
1i18B-3tz6A:
undetectable		 1i18A-3tz6A:
16.56
1i18B-3tz6A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 ILE A   5
LEU A  21
LEU A 332
THR A 334
ILE A  92
 None
 1.34A 1i18A-3tz6A:
undetectable
1i18B-3tz6A:
undetectable		 1i18A-3tz6A:
16.56
1i18B-3tz6A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 ILE A   7
LEU A  21
LEU A 332
THR A 334
ILE A  92
 None
 1.42A 1i18A-3tz6A:
undetectable
1i18B-3tz6A:
undetectable		 1i18A-3tz6A:
16.56
1i18B-3tz6A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 PHE A  70
ALA A  68
PRO A  62
GLY A 123
ILE A 124
 None
 1.22A 1kglA-3tz6A:
undetectable		 1kglA-3tz6A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 168
ALA A 171
ALA A 204
SER A 162
VAL A 159
 None
None
None
CYS  A 401 ( 4.6A)
None
 1.13A 2bxeB-3tz6A:
undetectable		 2bxeB-3tz6A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 265
PHE A 264
ARG A 272
LEU A 317
 None
 0.80A 2bxmA-3tz6A:
undetectable		 2bxmA-3tz6A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 SER A 257
TYR A 156
HIS A 256
 None
None
CYS  A 401 (-3.9A)
 0.76A 2r2vD-3tz6A:
undetectable		 2r2vD-3tz6A:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A  99
GLU A 221
SER A  74
 SO4  A 405 (-2.9A)
None
None
 0.71A 2xkkA-3tz6A:
undetectable
2xkkC-3tz6A:
undetectable		 2xkkA-3tz6A:
18.32
2xkkC-3tz6A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 341
ARG A 120
PHE A  84
GLY A  88
PHE A  35
 None
SO4  A 408 (-2.6A)
None
None
None
 1.34A 2zznB-3tz6A:
4.5		 2zznB-3tz6A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 110
SER A 109
GLN A 336
VAL A 297
 GOL  A 404 ( 4.1A)
GOL  A 404 (-2.7A)
GOL  A 404 (-3.7A)
None
 1.26A 3b9lA-3tz6A:
undetectable		 3b9lA-3tz6A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A   8
GLY A   9
GLY A  12
ASP A  56
ALA A  57
 None
None
SO4  A 406 (-3.5A)
None
None
 0.87A 3fuuA-3tz6A:
5.7		 3fuuA-3tz6A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 7 ALA A  29
PRO A  28
ARG A  25
ALA A 338
 None
 1.10A 3twpC-3tz6A:
3.2		 3twpC-3tz6A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 302
LEU A 319
ILE A 305
VAL A 141
 None
 0.95A 4a9kA-3tz6A:
undetectable		 4a9kA-3tz6A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 ALA A  29
SER A   4
GLN A  16
THR A  20
ILE A   7
 None
 1.34A 4bb2A-3tz6A:
undetectable
4bb2B-3tz6A:
undetectable		 4bb2A-3tz6A:
21.77
4bb2B-3tz6A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 139
VAL A 321
LEU A 258
LEU A 142
LEU A 151
 None
 1.15A 4or0B-3tz6A:
undetectable		 4or0B-3tz6A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 142
VAL A 302
LEU A 285
LEU A 139
LEU A 276
 None
 1.26A 4or0B-3tz6A:
undetectable		 4or0B-3tz6A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 142
LEU A 277
ALA A 273
LEU A 317
VAL A 321
 None
 1.02A 4p65C-3tz6A:
undetectable
4p65D-3tz6A:
undetectable
4p65J-3tz6A:
undetectable
4p65L-3tz6A:
undetectable		 4p65C-3tz6A:
6.54
4p65D-3tz6A:
7.47
4p65J-3tz6A:
7.47
4p65L-3tz6A:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 317
VAL A 321
LEU A 142
LEU A 277
ALA A 273
 None
 1.00A 4p65B-3tz6A:
undetectable
4p65D-3tz6A:
undetectable
4p65G-3tz6A:
undetectable
4p65H-3tz6A:
undetectable		 4p65B-3tz6A:
7.47
4p65D-3tz6A:
7.47
4p65G-3tz6A:
6.54
4p65H-3tz6A:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		6 / 12 VAL A 321
LEU A 317
ILE A 260
LEU A 142
LEU A 277
ALA A 273
 None
 1.17A 4p65B-3tz6A:
undetectable
4p65D-3tz6A:
undetectable
4p65I-3tz6A:
undetectable
4p65J-3tz6A:
undetectable		 4p65B-3tz6A:
7.47
4p65D-3tz6A:
7.47
4p65I-3tz6A:
6.54
4p65J-3tz6A:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 GLN A  13
GLY A   9
GLU A  58
ALA A  57
ALA A  72
 SO4  A 406 (-4.2A)
None
None
None
None
 1.19A 4pclA-3tz6A:
5.1		 4pclA-3tz6A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 ARG A 120
GLY A   6
ALA A 338
THR A  90
ILE A   5
 SO4  A 408 (-2.6A)
None
None
None
None
 1.41A 5eeuD-3tz6A:
undetectable
5eeuE-3tz6A:
undetectable		 5eeuD-3tz6A:
12.54
5eeuE-3tz6A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 ARG A 120
GLY A   6
ALA A 338
THR A  90
ILE A   5
 SO4  A 408 (-2.6A)
None
None
None
None
 1.41A 5eevD-3tz6A:
undetectable
5eevE-3tz6A:
undetectable		 5eevD-3tz6A:
12.54
5eevE-3tz6A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 ARG A 120
GLY A   6
ALA A 338
THR A  90
ILE A   5
 SO4  A 408 (-2.6A)
None
None
None
None
 1.41A 5eewD-3tz6A:
undetectable
5eewE-3tz6A:
undetectable		 5eewD-3tz6A:
12.54
5eewE-3tz6A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 ARG A 120
GLY A   6
ALA A 338
THR A  90
ILE A   5
 SO4  A 408 (-2.6A)
None
None
None
None
 1.41A 5eexD-3tz6A:
undetectable
5eexE-3tz6A:
undetectable		 5eexD-3tz6A:
12.54
5eexE-3tz6A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 ARG A 120
GLY A   6
ALA A 338
THR A  90
ILE A   5
 SO4  A 408 (-2.6A)
None
None
None
None
 1.41A 5eeyD-3tz6A:
undetectable
5eeyE-3tz6A:
undetectable		 5eeyD-3tz6A:
12.54
5eeyE-3tz6A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 ARG A 120
GLY A   6
ALA A 338
THR A  90
ILE A   5
 SO4  A 408 (-2.6A)
None
None
None
None
 1.41A 5eezD-3tz6A:
undetectable
5eezE-3tz6A:
undetectable		 5eezD-3tz6A:
12.54
5eezE-3tz6A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 ARG A 120
GLY A   6
ALA A 338
THR A  90
ILE A   5
 SO4  A 408 (-2.6A)
None
None
None
None
 1.41A 5ef0D-3tz6A:
undetectable
5ef0E-3tz6A:
undetectable		 5ef0D-3tz6A:
12.54
5ef0E-3tz6A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 ARG A 120
GLY A   6
ALA A 338
THR A  90
ILE A   5
 SO4  A 408 (-2.6A)
None
None
None
None
 1.41A 5ef1D-3tz6A:
undetectable
5ef1E-3tz6A:
undetectable		 5ef1D-3tz6A:
12.54
5ef1E-3tz6A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 ARG A 120
GLY A   6
ALA A 338
THR A  90
ILE A   5
 SO4  A 408 (-2.6A)
None
None
None
None
 1.41A 5ef2D-3tz6A:
undetectable
5ef2E-3tz6A:
undetectable		 5ef2D-3tz6A:
12.54
5ef2E-3tz6A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 ARG A 120
GLY A   6
ALA A 338
THR A  90
ILE A   5
 SO4  A 408 (-2.6A)
None
None
None
None
 1.40A 5ef3D-3tz6A:
undetectable
5ef3E-3tz6A:
undetectable		 5ef3D-3tz6A:
12.54
5ef3E-3tz6A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 ASN A 261
SER A 259
SER A 154
 None
 0.70A 5gsnA-3tz6A:
3.0		 5gsnA-3tz6A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 5 SER A  74
SER A  95
SER A  96
SER A  71
 None
None
None
SO4  A 406 ( 4.4A)
 1.49A 5hswA-3tz6A:
undetectable		 5hswA-3tz6A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 MET A  18
ALA A 126
SER A  95
VAL A  91
ILE A  92
 None
 1.47A 5mlmA-3tz6A:
2.4		 5mlmA-3tz6A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 343
ILE A   5
LEU A   3
ILE A  67
ILE A  92
 None
 0.97A 5nunA-3tz6A:
undetectable		 5nunA-3tz6A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 4 VAL A 207
VAL A 250
TYR A 156
GLN A 157
 None
None
None
CYS  A 401 (-4.1A)
 1.07A 5qggA-3tz6A:
undetectable		 5qggA-3tz6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 250
TYR A 156
GLN A 157
 None
None
CYS  A 401 (-4.1A)
 0.60A 5qgkA-3tz6A:
undetectable		 5qgkA-3tz6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 4 VAL A 207
VAL A 250
TYR A 156
GLN A 157
 None
None
None
CYS  A 401 (-4.1A)
 1.09A 5qgoA-3tz6A:
undetectable		 5qgoA-3tz6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 4 VAL A 207
VAL A 250
TYR A 156
GLN A 157
 None
None
None
CYS  A 401 (-4.1A)
 1.07A 5qgpA-3tz6A:
undetectable		 5qgpA-3tz6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 4 VAL A 207
VAL A 250
TYR A 156
GLN A 157
 None
None
None
CYS  A 401 (-4.1A)
 1.09A 5qgqA-3tz6A:
undetectable		 5qgqA-3tz6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 250
TYR A 156
GLN A 157
 None
None
CYS  A 401 (-4.1A)
 0.58A 5qgrA-3tz6A:
undetectable		 5qgrA-3tz6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 250
TYR A 156
GLN A 157
 None
None
CYS  A 401 (-4.1A)
 0.57A 5qgtA-3tz6A:
undetectable		 5qgtA-3tz6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 4 VAL A 207
VAL A 250
TYR A 156
GLN A 157
 None
None
None
CYS  A 401 (-4.1A)
 1.07A 5qhbA-3tz6A:
undetectable		 5qhbA-3tz6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 6 THR A  90
ARG A 120
ILE A 337
GLU A 339
 None
SO4  A 408 (-2.6A)
None
GOL  A 404 (-3.7A)
 1.29A 5uigA-3tz6A:
undetectable		 5uigA-3tz6A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A   9
GLY A  12
VAL A  17
ALA A  57
ALA A  72
 None
SO4  A 406 (-3.5A)
None
None
None
 0.81A 5x7fA-3tz6A:
undetectable		 5x7fA-3tz6A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A  77
GLY A 163
SER A 160
ALA A 158
VAL A  14
 None
SO4  A 406 (-3.2A)
None
None
SO4  A 406 (-3.4A)
 1.44A 6hu9L-3tz6A:
undetectable
6hu9P-3tz6A:
undetectable
6hu9T-3tz6A:
undetectable		 6hu9L-3tz6A:
23.18
6hu9P-3tz6A:
20.06
6hu9T-3tz6A:
11.00