SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tze'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 3tze TRYPTOPHANYL-TRNA
SYNTHETASE
(Encephalitozoon
cuniculi) 		5 / 12 HIS A  98
MET A  94
ILE A  96
PHE A 360
TYR A 364
 None
 1.32A 1ot7B-3tzeA:
undetectable		 1ot7B-3tzeA:
19.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3tze TRYPTOPHANYL-TRNA
SYNTHETASE
(Encephalitozoon
cuniculi) 		8 / 12 TYR A  84
THR A  85
GLY A  86
GLY A  88
THR A 121
GLU A 124
GLN A 232
PHE A 236
 TRP  A 386 (-3.8A)
TRP  A 386 (-4.3A)
TRP  A 386 (-3.3A)
TRP  A 386 ( 4.0A)
TRP  A 386 (-3.6A)
TRP  A 386 (-2.8A)
TRP  A 386 (-3.2A)
None
 0.61A 2akeA-3tzeA:
48.5		 2akeA-3tzeA:
42.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3tze TRYPTOPHANYL-TRNA
SYNTHETASE
(Encephalitozoon
cuniculi) 		9 / 12 TYR A  84
THR A  85
GLY A  86
GLY A  88
GLN A 119
THR A 121
GLU A 124
GLN A 232
PHE A 236
 TRP  A 386 (-3.8A)
TRP  A 386 (-4.3A)
TRP  A 386 (-3.3A)
TRP  A 386 ( 4.0A)
TRP  A 386 (-3.9A)
TRP  A 386 (-3.6A)
TRP  A 386 (-2.8A)
TRP  A 386 (-3.2A)
None
 0.58A 2azxA-3tzeA:
48.7		 2azxA-3tzeA:
39.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3tze TRYPTOPHANYL-TRNA
SYNTHETASE
(Encephalitozoon
cuniculi) 		9 / 12 TYR A  84
THR A  85
GLY A  86
GLY A  88
GLN A 119
THR A 121
GLU A 124
GLN A 232
PHE A 236
 TRP  A 386 (-3.8A)
TRP  A 386 (-4.3A)
TRP  A 386 (-3.3A)
TRP  A 386 ( 4.0A)
TRP  A 386 (-3.9A)
TRP  A 386 (-3.6A)
TRP  A 386 (-2.8A)
TRP  A 386 (-3.2A)
None
 0.56A 2azxB-3tzeA:
49.0		 2azxB-3tzeA:
39.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 3tze TRYPTOPHANYL-TRNA
SYNTHETASE
(Encephalitozoon
cuniculi) 		4 / 8 TYR A 339
ASP A 316
SER A 297
TYR A 296
 None
 1.11A 2bteA-3tzeA:
8.9		 2bteA-3tzeA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 3tze TRYPTOPHANYL-TRNA
SYNTHETASE
(Encephalitozoon
cuniculi) 		4 / 8 TYR A 339
ASP A 316
SER A 297
TYR A 296
 None
 1.07A 2bteD-3tzeA:
4.3		 2bteD-3tzeA:
18.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3tze TRYPTOPHANYL-TRNA
SYNTHETASE
(Encephalitozoon
cuniculi) 		8 / 11 TYR A  84
GLY A  86
GLY A  88
GLN A 119
THR A 121
GLU A 124
GLN A 232
PHE A 236
 TRP  A 386 (-3.8A)
TRP  A 386 (-3.3A)
TRP  A 386 ( 4.0A)
TRP  A 386 (-3.9A)
TRP  A 386 (-3.6A)
TRP  A 386 (-2.8A)
TRP  A 386 (-3.2A)
None
 0.56A 2dr2A-3tzeA:
48.6		 2dr2A-3tzeA:
42.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 3tze TRYPTOPHANYL-TRNA
SYNTHETASE
(Encephalitozoon
cuniculi) 		3 / 3 GLY A 311
ARG A 300
TYR A 339
 None
 0.83A 2opxA-3tzeA:
2.4		 2opxA-3tzeA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 3tze TRYPTOPHANYL-TRNA
SYNTHETASE
(Encephalitozoon
cuniculi) 		4 / 5 GLN A 232
PHE A 202
TRP A 128
GLY A  88
 TRP  A 386 (-3.2A)
None
None
TRP  A 386 ( 4.0A)
 1.22A 2qmzA-3tzeA:
undetectable
2qmzB-3tzeA:
undetectable		 2qmzA-3tzeA:
21.48
2qmzB-3tzeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 3tze TRYPTOPHANYL-TRNA
SYNTHETASE
(Encephalitozoon
cuniculi) 		4 / 8 TYR A 339
ASP A 316
SER A 297
TYR A 296
 None
 1.14A 2v0gA-3tzeA:
1.3		 2v0gA-3tzeA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BMC_C_FOLC270_0
(PTERIDINE REDUCTASE)		 3tze TRYPTOPHANYL-TRNA
SYNTHETASE
(Encephalitozoon
cuniculi) 		5 / 12 SER A 252
PHE A  68
PHE A  37
LEU A  48
GLU A  46
 None
 1.24A 3bmcC-3tzeA:
3.6		 3bmcC-3tzeA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3tze TRYPTOPHANYL-TRNA
SYNTHETASE
(Encephalitozoon
cuniculi) 		4 / 5 ILE A 114
THR A  85
PHE A 215
TYR A  82
 None
TRP  A 386 (-4.3A)
None
None
 1.32A 3em0A-3tzeA:
undetectable		 3em0A-3tzeA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 3tze TRYPTOPHANYL-TRNA
SYNTHETASE
(Encephalitozoon
cuniculi) 		5 / 11 TYR A 321
VAL A 317
PRO A 260
ILE A 100
ILE A  96
 None
 1.40A 3ganA-3tzeA:
undetectable		 3ganA-3tzeA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 3tze TRYPTOPHANYL-TRNA
SYNTHETASE
(Encephalitozoon
cuniculi) 		4 / 8 GLY A 201
CYH A 210
PHE A 215
PHE A 169
 None
 0.90A 3ko0D-3tzeA:
undetectable
3ko0E-3tzeA:
undetectable		 3ko0D-3tzeA:
13.90
3ko0E-3tzeA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 3tze TRYPTOPHANYL-TRNA
SYNTHETASE
(Encephalitozoon
cuniculi) 		4 / 8 PHE A 169
GLY A 201
CYH A 210
PHE A 215
 None
 0.84A 3ko0B-3tzeA:
undetectable
3ko0J-3tzeA:
undetectable		 3ko0B-3tzeA:
13.90
3ko0J-3tzeA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 3tze TRYPTOPHANYL-TRNA
SYNTHETASE
(Encephalitozoon
cuniculi) 		4 / 7 GLY A 201
CYH A 210
PHE A 215
PHE A 169
 None
 0.89A 3ko0L-3tzeA:
undetectable
3ko0N-3tzeA:
undetectable		 3ko0L-3tzeA:
13.90
3ko0N-3tzeA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 3tze TRYPTOPHANYL-TRNA
SYNTHETASE
(Encephalitozoon
cuniculi) 		4 / 7 PHE A 169
GLY A 201
CYH A 210
PHE A 215
 None
 0.86A 3ko0K-3tzeA:
undetectable
3ko0S-3tzeA:
undetectable		 3ko0K-3tzeA:
13.90
3ko0S-3tzeA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 3tze TRYPTOPHANYL-TRNA
SYNTHETASE
(Encephalitozoon
cuniculi) 		4 / 6 PHE A  68
PHE A  37
ALA A  53
LEU A 104
 None
 0.96A 4ejgD-3tzeA:
undetectable		 4ejgD-3tzeA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3tze TRYPTOPHANYL-TRNA
SYNTHETASE
(Encephalitozoon
cuniculi) 		4 / 5 LYS A 334
LEU A 332
GLU A 331
LEU A 326
 None
 1.27A 4k4yA-3tzeA:
undetectable		 4k4yA-3tzeA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3tze TRYPTOPHANYL-TRNA
SYNTHETASE
(Encephalitozoon
cuniculi) 		4 / 5 LYS A 334
LEU A 332
GLU A 331
LEU A 326
 None
 1.28A 4k4yI-3tzeA:
undetectable		 4k4yI-3tzeA:
21.37