SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tzq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
marinum) 		5 / 12 ARG B 179
GLY B 177
GLY B 174
ILE B 137
LEU B 223
 None
 1.09A 1p91B-3tzqB:
4.9		 1p91B-3tzqB:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
marinum) 		6 / 11 GLY B  14
ASP B  38
LEU B  39
ASP B  61
ALA B  89
VAL B 113
 None
 0.50A 1uayA-3tzqB:
29.0		 1uayA-3tzqB:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
marinum) 		6 / 10 GLY B  14
ASP B  38
LEU B  39
ASP B  61
ALA B  89
VAL B 113
 None
 0.48A 1uayB-3tzqB:
29.8		 1uayB-3tzqB:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
marinum) 		5 / 12 GLY B  14
GLY B  17
LEU B  39
ASP B  61
VAL B  60
 None
 0.95A 1zq9B-3tzqB:
6.2		 1zq9B-3tzqB:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
marinum) 		5 / 12 GLY B  14
ASP B  38
ASP B  61
ASN B  88
ALA B  89
 None
 0.95A 2bm9E-3tzqB:
5.4		 2bm9E-3tzqB:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
marinum) 		5 / 12 LEU B  71
THR B  75
MET B 121
ASN B  87
ILE B  12
 None
 1.36A 2ydoA-3tzqB:
undetectable		 2ydoA-3tzqB:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
marinum) 		4 / 4 PRO B  40
THR B  42
GLY B  20
THR B  23
 None
 1.15A 3ib1A-3tzqB:
undetectable		 3ib1A-3tzqB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
marinum) 		5 / 12 ILE B 140
VAL B  34
ARG B  53
ILE B  19
ALA B  89
 None
 1.15A 3ohtA-3tzqB:
undetectable
3ohtB-3tzqB:
undetectable		 3ohtA-3tzqB:
23.32
3ohtB-3tzqB:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
marinum) 		4 / 5 SER B 142
ILE B  19
TYR B 155
GLY B 186
 GOL  B 268 ( 3.8A)
None
None
GOL  B 268 (-3.7A)
 0.90A 3uboB-3tzqB:
6.9		 3uboB-3tzqB:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
marinum) 		5 / 12 ILE B  76
VAL B   9
LEU B  27
SER B  24
ALA B  37
 None
 1.09A 3w67C-3tzqB:
2.0		 3w67C-3tzqB:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
marinum) 		3 / 3 ARG B 116
TYR B 168
ASN B 139
 None
 0.93A 4ffwB-3tzqB:
3.1		 4ffwB-3tzqB:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
marinum) 		4 / 5 LEU B 193
ARG B 213
PRO B 185
SER B 142
 None
None
None
GOL  B 268 ( 3.8A)
 1.48A 4kmmB-3tzqB:
3.2		 4kmmB-3tzqB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
marinum) 		5 / 11 GLY B  14
THR B  23
ASP B  38
LEU B  39
ASP B  61
 None
 0.95A 4pghA-3tzqB:
6.8		 4pghA-3tzqB:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
marinum) 		5 / 12 GLY B  14
THR B  23
ASP B  38
LEU B  39
ASP B  61
 None
 1.07A 4pghB-3tzqB:
6.4		 4pghB-3tzqB:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
marinum) 		4 / 5 ALA B  15
PRO B 217
GLY B 212
LEU B 193
 None
 0.95A 5eslA-3tzqB:
undetectable		 5eslA-3tzqB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
marinum) 		4 / 7 VAL B  68
GLU B  65
ASN B 139
ILE B 162
 None
 1.06A 5jh7C-3tzqB:
6.9		 5jh7C-3tzqB:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
marinum) 		4 / 6 GLY B  20
THR B  23
SER B  24
ASN B  88
 None
 0.87A 5k4pA-3tzqB:
undetectable		 5k4pA-3tzqB:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
marinum) 		5 / 9 PRO B 185
GLY B 245
SER B 142
VAL B 188
LEU B 187
 None
None
GOL  B 268 ( 3.8A)
None
GOL  B 268 (-4.1A)
 1.29A 5o96E-3tzqB:
3.7
5o96F-3tzqB:
2.8		 5o96E-3tzqB:
22.77
5o96F-3tzqB:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
marinum) 		4 / 8 ALA B  10
ILE B 137
ALA B 136
LEU B 129
 None
 0.65A 5te8B-3tzqB:
undetectable		 5te8B-3tzqB:
19.59