SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tzt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 3tzt GLYCOSYL TRANSFERASE
FAMILY 8
(Anaerococcus
prevotii) 		5 / 10 ALA A   4
LEU A 118
ARG A  31
ILE A 122
LEU A 163
 EDO  A 302 (-4.5A)
EDO  A 302 (-4.3A)
None
None
None
 1.35A 1a52A-3tztA:
undetectable		 1a52A-3tztA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 3tzt GLYCOSYL TRANSFERASE
FAMILY 8
(Anaerococcus
prevotii) 		5 / 10 ALA A   4
LEU A 118
ARG A  31
ILE A 122
LEU A 163
 EDO  A 302 (-4.5A)
EDO  A 302 (-4.3A)
None
None
None
 1.35A 1a52B-3tztA:
undetectable		 1a52B-3tztA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 3tzt GLYCOSYL TRANSFERASE
FAMILY 8
(Anaerococcus
prevotii) 		5 / 10 ALA A   4
LEU A 118
ARG A  31
ILE A 122
LEU A 163
 EDO  A 302 (-4.5A)
EDO  A 302 (-4.3A)
None
None
None
 1.26A 1qkuA-3tztA:
undetectable		 1qkuA-3tztA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 3tzt GLYCOSYL TRANSFERASE
FAMILY 8
(Anaerococcus
prevotii) 		5 / 10 ALA A   4
LEU A 118
ARG A  31
ILE A 122
LEU A 163
 EDO  A 302 (-4.5A)
EDO  A 302 (-4.3A)
None
None
None
 1.25A 1qkuB-3tztA:
undetectable		 1qkuB-3tztA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 3tzt GLYCOSYL TRANSFERASE
FAMILY 8
(Anaerococcus
prevotii) 		5 / 10 ALA A   4
LEU A 118
ARG A  31
ILE A 122
LEU A 163
 EDO  A 302 (-4.5A)
EDO  A 302 (-4.3A)
None
None
None
 1.24A 1qkuC-3tztA:
undetectable		 1qkuC-3tztA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3tzt GLYCOSYL TRANSFERASE
FAMILY 8
(Anaerococcus
prevotii) 		4 / 6 LEU A 102
PHE A  33
ALA A   4
LEU A 160
 EDO  A 302 ( 4.9A)
None
EDO  A 302 (-4.5A)
None
 0.95A 1ukbA-3tztA:
undetectable		 1ukbA-3tztA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3tzt GLYCOSYL TRANSFERASE
FAMILY 8
(Anaerococcus
prevotii) 		5 / 12 LEU A   6
LEU A 160
LEU A 114
LEU A  20
THR A   8
 None
 1.50A 2oaxA-3tztA:
undetectable		 2oaxA-3tztA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 3tzt GLYCOSYL TRANSFERASE
FAMILY 8
(Anaerococcus
prevotii) 		5 / 9 LEU A  94
ALA A   4
ASP A   3
LEU A 160
ILE A 101
 None
EDO  A 302 (-4.5A)
EDO  A 302 (-4.0A)
None
None
 1.41A 3wsjA-3tztA:
undetectable		 3wsjA-3tztA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 3tzt GLYCOSYL TRANSFERASE
FAMILY 8
(Anaerococcus
prevotii) 		5 / 12 LEU A   5
ALA A   4
LEU A 118
ILE A 122
LEU A 163
 None
EDO  A 302 (-4.5A)
EDO  A 302 (-4.3A)
None
None
 1.09A 4j24D-3tztA:
undetectable		 4j24D-3tztA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 3tzt GLYCOSYL TRANSFERASE
FAMILY 8
(Anaerococcus
prevotii) 		5 / 12 ILE A 122
TYR A 210
VAL A 238
LEU A 104
LEU A 102
 None
EDO  A 301 (-4.2A)
None
None
EDO  A 302 ( 4.9A)
 1.08A 4qzuC-3tztA:
undetectable		 4qzuC-3tztA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 3tzt GLYCOSYL TRANSFERASE
FAMILY 8
(Anaerococcus
prevotii) 		5 / 12 LEU A   5
ALA A   4
LEU A 118
ILE A 122
LEU A 163
 None
EDO  A 302 (-4.5A)
EDO  A 302 (-4.3A)
None
None
 1.00A 5gs4A-3tztA:
undetectable		 5gs4A-3tztA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3tzt GLYCOSYL TRANSFERASE
FAMILY 8
(Anaerococcus
prevotii) 		5 / 12 LEU A   5
ALA A   4
LEU A 118
ILE A 122
LEU A 163
 None
EDO  A 302 (-4.5A)
EDO  A 302 (-4.3A)
None
None
 1.10A 5gtrA-3tztA:
undetectable		 5gtrA-3tztA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 3tzt GLYCOSYL TRANSFERASE
FAMILY 8
(Anaerococcus
prevotii) 		4 / 4 LEU A   5
MET A  17
ILE A  32
LEU A  54
 None
 1.35A 5nfpA-3tztA:
undetectable		 5nfpA-3tztA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3tzt GLYCOSYL TRANSFERASE
FAMILY 8
(Anaerococcus
prevotii) 		5 / 12 LEU A 118
ALA A 130
LEU A   7
LEU A  20
VAL A 110
 EDO  A 302 (-4.3A)
None
None
None
None
 0.95A 5tudA-3tztA:
undetectable		 5tudA-3tztA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 3tzt GLYCOSYL TRANSFERASE
FAMILY 8
(Anaerococcus
prevotii) 		3 / 3 GLU A 168
ASP A 171
PRO A 172
 None
 0.76A 6berA-3tztA:
undetectable		 6berA-3tztA:
25.00