SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tzw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 3tzw POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 12 ARG A 788
VAL A 744
LEU A 816
ALA A 819
PHE A 777
 None
 0.87A 1gseB-3tzwA:
undetectable		 1gseB-3tzwA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 3tzw POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 11 ILE A1057
ALA A1055
VAL A 625
LEU A 689
ALA A 685
 None
 1.25A 1n4hA-3tzwA:
undetectable		 1n4hA-3tzwA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 3tzw POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		4 / 5 LEU A1015
ASP A1020
MET A1029
LEU A 787
 None
None
EDO  A   8 (-4.3A)
None
 1.30A 2jfaA-3tzwA:
undetectable		 2jfaA-3tzwA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3tzw POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		6 / 12 GLN A 773
THR A 775
GLY A 720
GLY A 718
LEU A 802
TYR A 767
 SO4  A   6 ( 3.7A)
None
None
None
SO4  A   6 (-4.5A)
None
 1.01A 2zw9B-3tzwA:
undetectable		 2zw9B-3tzwA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3tzw POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 907
GLY A 879
MET A 913
PHE A 902
LEU A 963
 None
 1.18A 3bxoA-3tzwA:
undetectable		 3bxoA-3tzwA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 3tzw POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 907
GLY A 879
MET A 913
PHE A 902
HIS A 909
 None
None
None
None
SO4  A   6 (-4.1A)
 1.35A 3pfgA-3tzwA:
undetectable		 3pfgA-3tzwA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3tzw POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		4 / 8 SER A 656
ARG A 668
ILE A 661
GLU A 652
 None
 1.27A 4cx7C-3tzwA:
undetectable
4cx7D-3tzwA:
undetectable		 4cx7C-3tzwA:
23.02
4cx7D-3tzwA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3tzw POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 9 VAL A 774
ILE A 823
GLU A 923
LEU A 916
LEU A 963
 None
 1.38A 4l1xB-3tzwA:
undetectable		 4l1xB-3tzwA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 3tzw POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 12 ARG A 944
GLY A 935
GLY A 972
PHE A 937
GLU A 942
 None
 1.23A 4r29C-3tzwA:
undetectable		 4r29C-3tzwA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3tzw POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 690
ALA A 642
LEU A 689
GLY A 688
 None
 0.91A 4xk8a-3tzwA:
undetectable		 4xk8a-3tzwA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3tzw POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 12 ILE A1041
TYR A1033
HIS A 670
ALA A 675
ILE A 661
 None
 1.41A 5iwuA-3tzwA:
undetectable		 5iwuA-3tzwA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 3tzw POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 674
VAL A 676
LEU A 678
ALA A 628
 None
 0.60A 5jq7A-3tzwA:
undetectable		 5jq7A-3tzwA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3tzw POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 940
SER A 807
ILE A 781
PHE A 777
 None
 1.09A 5jw1B-3tzwA:
undetectable		 5jw1B-3tzwA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3tzw POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 781
VAL A 744
THR A 820
ILE A 823
 None
 0.95A 5mzrE-3tzwA:
undetectable		 5mzrE-3tzwA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 3tzw POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		4 / 4 ALA A 805
ALA A 808
ALA A 819
ALA A 822
 None
 0.78A 6gtqA-3tzwA:
undetectable
6gtqB-3tzwA:
undetectable		 6gtqA-3tzwA:
16.91
6gtqB-3tzwA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 3tzw POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		4 / 4 ALA A 819
ALA A 822
ALA A 805
ALA A 808
 None
 0.78A 6gtqA-3tzwA:
undetectable
6gtqB-3tzwA:
undetectable		 6gtqA-3tzwA:
16.91
6gtqB-3tzwA:
16.91