SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u0h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 3u0h XYLOSE ISOMERASE
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 5 LYS A 197
GLU A 196
ALA A 173
LEU A 137
 None
 1.11A 1eta2-3u0hA:
undetectable		 1eta2-3u0hA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 3u0h XYLOSE ISOMERASE
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 8 TYR A 113
LEU A 159
LEU A 117
GLU A 138
 None
None
None
EDO  A 280 ( 4.1A)
 1.10A 1i7zA-3u0hA:
undetectable		 1i7zA-3u0hA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 3u0h XYLOSE ISOMERASE
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		5 / 10 LYS A 197
GLU A 196
ALA A 173
LEU A 137
LEU A 156
 None
 1.23A 1ie4A-3u0hA:
undetectable
1ie4C-3u0hA:
undetectable		 1ie4A-3u0hA:
14.54
1ie4C-3u0hA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 3u0h XYLOSE ISOMERASE
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 7 TYR A  70
TRP A 103
HIS A 144
GLY A 141
 None
 1.36A 1mxgA-3u0hA:
6.6		 1mxgA-3u0hA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 3u0h XYLOSE ISOMERASE
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		5 / 12 LEU A 156
LYS A 197
GLU A 196
ALA A 173
LEU A 137
 None
 1.06A 1sn5B-3u0hA:
undetectable
1sn5D-3u0hA:
undetectable		 1sn5B-3u0hA:
17.58
1sn5D-3u0hA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 3u0h XYLOSE ISOMERASE
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		5 / 12 LYS A 197
GLU A 196
ALA A 173
LEU A 137
LEU A 156
 None
 1.06A 1sn5B-3u0hA:
undetectable
1sn5D-3u0hA:
undetectable		 1sn5B-3u0hA:
17.58
1sn5D-3u0hA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3u0h XYLOSE ISOMERASE
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 7 ARG A 268
GLU A 270
ALA A 246
PRO A   3
 None
 0.87A 2ejfA-3u0hA:
undetectable		 2ejfA-3u0hA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3u0h XYLOSE ISOMERASE
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		6 / 12 ALA A 100
LEU A 102
LEU A 117
GLN A 116
ARG A 122
VAL A 171
 None
None
None
GOL  A 283 (-4.6A)
EDO  A 281 (-4.0A)
None
 1.18A 3ix9A-3u0hA:
undetectable		 3ix9A-3u0hA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 3u0h XYLOSE ISOMERASE
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		5 / 12 VAL A  30
ALA A 245
ALA A 246
THR A   8
LEU A   9
 None
 0.89A 3mteB-3u0hA:
undetectable		 3mteB-3u0hA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 3u0h XYLOSE ISOMERASE
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		5 / 12 ALA A 246
LEU A  21
ILE A 226
GLY A 222
PRO A 221
 None
 1.11A 3ozwB-3u0hA:
undetectable		 3ozwB-3u0hA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 3u0h XYLOSE ISOMERASE
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 7 GLY A 184
ALA A 183
ALA A 157
ASP A 158
 None
 0.87A 3ur0B-3u0hA:
undetectable		 3ur0B-3u0hA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 3u0h XYLOSE ISOMERASE
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		5 / 12 ALA A 157
LEU A 159
THR A 161
LEU A 102
ILE A 114
 None
 1.13A 4g1bA-3u0hA:
undetectable		 4g1bA-3u0hA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 3u0h XYLOSE ISOMERASE
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 5 LEU A 235
ASP A 176
TRP A 180
ILE A 226
 None
 1.42A 4mwrA-3u0hA:
undetectable		 4mwrA-3u0hA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3u0h XYLOSE ISOMERASE
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 6 LEU A  37
VAL A  32
ARG A  56
VAL A  30
 None
 0.97A 5x7zA-3u0hA:
undetectable		 5x7zA-3u0hA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3u0h XYLOSE ISOMERASE
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 7 HIS A 144
ARG A 218
HIS A 250
GLU A 138
 None
EDO  A 280 (-4.1A)
None
EDO  A 280 ( 4.1A)
 1.21A 6mn4F-3u0hA:
undetectable		 6mn4F-3u0hA:
21.07