SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u0i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TLM_A_MILA128_1 (TRANSTHYRETIN)	3u0i	PROBABLE FAD-BINDING, PUTATIVE UNCHARACTERIZED PROTEIN (Brucella abortus)	3 / 3	LEU A 67 LEU A 81 SER A 139	None EDO A 146 ( 4.2A) EDO A 146 (-2.8A)	0.60A	1tlmA-3u0iA: undetectable	1tlmA-3u0iA: 22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G1B_A_ECNA403_1 (FLAVOHEMOGLOBIN)	3u0i	PROBABLE FAD-BINDING, PUTATIVE UNCHARACTERIZED PROTEIN (Brucella abortus)	5 / 12	THR A 37 THR A 49 VAL A 34 LEU A 23 TYR A 25	NHE A 145 ( 3.9A) NHE A 145 (-3.7A) None None None	1.13A	4g1bA-3u0iA: undetectable	4g1bA-3u0iA: 17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O8F_B_BRLB501_2 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3u0i	PROBABLE FAD-BINDING, PUTATIVE UNCHARACTERIZED PROTEIN (Brucella abortus)	4 / 6	ILE A 135 GLY A 43 ILE A 101 ILE A 15	None	0.65A	4o8fB-3u0iA: undetectable	4o8fB-3u0iA: 19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KIR_A_RCXA601_2 (PROSTAGLANDIN G/H SYNTHASE 2)	3u0i	PROBABLE FAD-BINDING, PUTATIVE UNCHARACTERIZED PROTEIN (Brucella abortus)	3 / 3	ARG A 39 ILE A 15 PHE A 40	None	0.59A	5kirA-3u0iA: undetectable	5kirA-3u0iA: 12.32

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1TLM_A_MILA128_1","TRANSTHYRETIN","3u0i","PROBABLE FAD-BINDING, PUTATIVE UNCHARACTERIZED PROTEIN","Brucella abortus",3,"LEU A  67;LEU A  81;SER A 139","None;EDO A 146 ( 4.2A);EDO A 146 (-2.8A)","0.60A","1tlmA-3u0iA:undetectable","1tlmA-3u0iA:22.56"],["4G1B_A_ECNA403_1","FLAVOHEMOGLOBIN","3u0i","PROBABLE FAD-BINDING, PUTATIVE UNCHARACTERIZED PROTEIN","Brucella abortus",5,"THR A  37;THR A  49;VAL A  34;LEU A  23;TYR A  25","NHE A 145 ( 3.9A);NHE A 145 (-3.7A);None;None;None","1.13A","4g1bA-3u0iA:undetectable","4g1bA-3u0iA:17.41"],["4O8F_B_BRLB501_2","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","3u0i","PROBABLE FAD-BINDING, PUTATIVE UNCHARACTERIZED PROTEIN","Brucella abortus",4,"ILE A 135;GLY A  43;ILE A 101;ILE A  15","None","0.65A","4o8fB-3u0iA:undetectable","4o8fB-3u0iA:19.57"],["5KIR_A_RCXA601_2","PROSTAGLANDIN G\/H SYNTHASE 2","3u0i","PROBABLE FAD-BINDING, PUTATIVE UNCHARACTERIZED PROTEIN","Brucella abortus",3,"ARG A  39;ILE A  15;PHE A  40","None","0.59A","5kirA-3u0iA:undetectable","5kirA-3u0iA:12.32"]]