SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u0n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3u0n MRUBY
(Entacmaea
quadricolor) 		5 / 12 ALA A  54
GLU A 208
SER A  61
LEU A 199
TYR A  96
 None
None
None
NRQ  A  64 ( 3.0A)
None
 1.34A 1u72A-3u0nA:
undetectable		 1u72A-3u0nA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3u0n MRUBY
(Entacmaea
quadricolor) 		5 / 11 GLY A 100
TYR A  96
PHE A 126
GLY A 123
ILE A 102
 None
 1.14A 2y7kA-3u0nA:
undetectable		 2y7kA-3u0nA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3u0n MRUBY
(Entacmaea
quadricolor) 		4 / 8 ALA A 222
TYR A 148
GLY A 226
ILE A 192
 None
 0.92A 2zm9A-3u0nA:
undetectable		 2zm9A-3u0nA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3u0n MRUBY
(Entacmaea
quadricolor) 		3 / 3 GLY A 152
PRO A 190
LEU A 154
 None
 0.58A 3hcpB-3u0nA:
undetectable		 3hcpB-3u0nA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3u0n MRUBY
(Entacmaea
quadricolor) 		4 / 6 PHE A  55
HIS A 118
VAL A 104
PHE A  24
 None
 1.14A 4a97E-3u0nA:
undetectable		 4a97E-3u0nA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 3u0n MRUBY
(Entacmaea
quadricolor) 		5 / 12 ILE A 102
ASP A  98
GLY A  99
VAL A 132
ALA A 131
 None
 1.23A 4foxD-3u0nA:
undetectable		 4foxD-3u0nA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 3u0n MRUBY
(Entacmaea
quadricolor) 		4 / 5 GLY A  37
ALA A 217
PHE A  69
GLU A 215
 None
None
None
NRQ  A  64 ( 3.0A)
 1.05A 4m93B-3u0nA:
undetectable
4m93C-3u0nA:
undetectable		 4m93B-3u0nA:
20.59
4m93C-3u0nA:
21.24