SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u1j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 3u1j SERINE PROTEASE NS3
(Dengue
virus) 		4 / 4 ILE B  25
MET B  49
VAL B 146
GLY B  37
 None
 1.29A 1e06B-3u1jB:
undetectable		 1e06B-3u1jB:
20.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 3u1j SERINE PROTEASE NS3
(Dengue
virus) 		5 / 9 PHE B  46
THR B  48
VAL B  52
ALA B  56
LEU B  58
 None
 0.74A 2m9qA-3u1jB:
6.6		 2m9qA-3u1jB:
55.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 3u1j SERINE PROTEASE
SUBUNIT NS2B
SERINE PROTEASE NS3
(Dengue
virus;
Dengue
virus) 		5 / 9 LEU A  51
PHE B  46
VAL B  52
ALA B  56
LEU B  58
 None
 1.01A 2m9qA-3u1jA:
undetectable		 2m9qA-3u1jA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3u1j SERINE PROTEASE NS3
(Dengue
virus) 		5 / 11 ALA B 166
SER B 163
PHE B 116
GLY B 148
ILE B 139
 None
 1.48A 2zmaA-3u1jB:
undetectable		 2zmaA-3u1jB:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 3u1j SERINE PROTEASE NS3
(Dengue
virus) 		5 / 12 GLY B 164
GLY B 124
ASP B  75
HIS B  51
SER B 163
 None
 1.22A 3dlcA-3u1jB:
undetectable		 3dlcA-3u1jB:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3u1j SERINE PROTEASE NS3
(Dengue
virus) 		5 / 12 HIS B  51
VAL B  72
ASP B  75
GLY B 133
SER B 135
 None
 0.89A 3sueC-3u1jB:
12.7		 3sueC-3u1jB:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3u1j SERINE PROTEASE NS3
(Dengue
virus) 		5 / 12 HIS B  51
VAL B  72
ASP B  75
GLY B 133
SER B 135
 None
 0.83A 3sufD-3u1jB:
12.8		 3sufD-3u1jB:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3u1j SERINE PROTEASE NS3
(Dengue
virus) 		5 / 12 ALA B 166
SER B 163
PHE B 116
GLY B 148
ILE B 139
 None
 1.50A 3vwqA-3u1jB:
undetectable		 3vwqA-3u1jB:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWR_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3u1j SERINE PROTEASE NS3
(Dengue
virus) 		5 / 11 ALA B 166
SER B 163
PHE B 116
GLY B 148
ILE B 139
 None
 1.50A 3vwrA-3u1jB:
undetectable		 3vwrA-3u1jB:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3u1j SERINE PROTEASE NS3
(Dengue
virus) 		4 / 5 LEU B  85
GLY B 148
ILE B  98
VAL B  97
 None
 0.87A 3wrkA-3u1jB:
undetectable		 3wrkA-3u1jB:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3u1j SERINE PROTEASE NS3
(Dengue
virus) 		5 / 11 LEU B  85
GLY B  39
ILE B 140
LEU B  76
GLY B 136
 None
 1.08A 3zosA-3u1jB:
1.7
3zosB-3u1jB:
undetectable		 3zosA-3u1jB:
19.50
3zosB-3u1jB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)		 3u1j SERINE PROTEASE NS3
(Dengue
virus) 		5 / 9 ARG B  84
ASN B  68
GLY B  81
GLY B  80
GLY B  82
 None
 1.05A 4h2fA-3u1jB:
undetectable		 4h2fA-3u1jB:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 3u1j SERINE PROTEASE NS3
(Dengue
virus) 		5 / 9 ARG B  84
ASN B  68
GLY B  81
GLY B  80
GLY B  82
 None
 1.10A 4h2gA-3u1jB:
undetectable		 4h2gA-3u1jB:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 3u1j SERINE PROTEASE NS3
(Dengue
virus) 		4 / 6 ASN B 108
ILE B 139
ILE B 140
VAL B 146
 None
 0.98A 4olmA-3u1jB:
undetectable		 4olmA-3u1jB:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 3u1j SERINE PROTEASE NS3
(Dengue
virus) 		3 / 3 VAL B  57
THR B  59
ARG B  64
 None
 0.55A 5b2sB-3u1jB:
undetectable		 5b2sB-3u1jB:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 3u1j SERINE PROTEASE NS3
(Dengue
virus) 		3 / 3 VAL B  57
THR B  59
ARG B  64
 None
 0.57A 5b2tB-3u1jB:
undetectable		 5b2tB-3u1jB:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3u1j SERINE PROTEASE NS3
(Dengue
virus) 		5 / 9 THR B 168
TRP B  83
GLN B  96
LEU B 149
LEU B  76
 None
 1.35A 5fhzB-3u1jB:
undetectable		 5fhzB-3u1jB:
16.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 3u1j SERINE PROTEASE NS3
(Dengue
virus) 		4 / 5 HIS B  51
SER B 135
GLY B 151
TYR B 161
 None
 0.62A 5yodB-3u1jB:
27.0		 5yodB-3u1jB:
54.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 3u1j SERINE PROTEASE NS3
(Dengue
virus) 		4 / 5 HIS B  51
SER B 135
GLY B 151
TYR B 161
 None
 0.48A 5yodD-3u1jB:
27.0		 5yodD-3u1jB:
54.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YOD_F_BEZF201_0
(NS3 PROTEASE)		 3u1j SERINE PROTEASE NS3
(Dengue
virus) 		4 / 5 HIS B  51
SER B 135
TYR B 150
TYR B 161
 None
 0.63A 5yodF-3u1jB:
26.6		 5yodF-3u1jB:
54.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 3u1j SERINE PROTEASE NS3
(Dengue
virus) 		5 / 5 HIS B  51
SER B 135
TYR B 150
GLY B 151
TYR B 161
 None
 0.57A 5yodH-3u1jB:
26.2		 5yodH-3u1jB:
54.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 3u1j SERINE PROTEASE NS3
(Dengue
virus) 		6 / 12 HIS B  51
VAL B  72
ASP B  75
GLY B 133
SER B 135
VAL B 155
 None
 1.35A 6c2mC-3u1jB:
12.6		 6c2mC-3u1jB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 3u1j SERINE PROTEASE NS3
(Dengue
virus) 		6 / 12 HIS B  51
VAL B  72
ASP B  75
GLY B 133
SER B 135
VAL B 162
 None
 0.91A 6c2mC-3u1jB:
12.6		 6c2mC-3u1jB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3u1j SERINE PROTEASE NS3
(Dengue
virus) 		4 / 6 TRP B  83
GLY B 144
ALA B  87
LEU B  85
 None
 0.97A 6fosA-3u1jB:
undetectable		 6fosA-3u1jB:
21.48