SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u1t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3u1t DMMA HALOALKANE
DEHALOGENASE
(unidentified) 		5 / 12 LEU A  84
GLU A 228
ASP A 320
HIS A 315
LEU A 215
 None
None
None
MLI  A 351 (-3.3A)
None
 1.40A 1d4fB-3u1tA:
5.4		 1d4fB-3u1tA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 3u1t DMMA HALOALKANE
DEHALOGENASE
(unidentified) 		4 / 5 PHE A 210
LEU A  84
MET A 107
LEU A 119
 CL  A 350 (-4.7A)
None
None
None
 1.45A 1skxA-3u1tA:
undetectable		 1skxA-3u1tA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 3u1t DMMA HALOALKANE
DEHALOGENASE
(unidentified) 		5 / 11 ASP A 127
ASP A 121
GLY A 146
ILE A 142
PRO A 102
 None
 0.97A 1t3rB-3u1tA:
undetectable		 1t3rB-3u1tA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 3u1t DMMA HALOALKANE
DEHALOGENASE
(unidentified) 		3 / 3 VAL A 204
ASN A  78
TRP A 145
 None
CL  A 350 (-4.4A)
CL  A 350 (-4.7A)
 1.06A 2y00B-3u1tA:
undetectable		 2y00B-3u1tA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 3u1t DMMA HALOALKANE
DEHALOGENASE
(unidentified) 		5 / 12 PHE A 166
VAL A 307
LEU A 298
VAL A 294
VAL A 171
 None
 1.22A 3czvA-3u1tA:
undetectable
3czvB-3u1tA:
undetectable		 3czvA-3u1tA:
21.17
3czvB-3u1tA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 3u1t DMMA HALOALKANE
DEHALOGENASE
(unidentified) 		5 / 9 ASP A 127
ASP A 121
GLY A 146
ILE A 142
PRO A 102
 None
 1.00A 3ekvB-3u1tA:
undetectable		 3ekvB-3u1tA:
15.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FBW_A_BEZA501_0
(HALOALKANE
DEHALOGENASE)		 3u1t DMMA HALOALKANE
DEHALOGENASE
(unidentified) 		6 / 9 ASN A  78
ASP A 144
TRP A 145
PHE A 191
PHE A 210
HIS A 315
 CL  A 350 (-4.4A)
CL  A 350 ( 4.6A)
CL  A 350 (-4.7A)
None
CL  A 350 (-4.7A)
MLI  A 351 (-3.3A)
 0.78A 3fbwA-3u1tA:
46.6		 3fbwA-3u1tA:
50.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3u1t DMMA HALOALKANE
DEHALOGENASE
(unidentified) 		5 / 11 GLY A 108
ASP A 103
ALA A  62
ALA A 111
ALA A 234
 None
 1.04A 3g88A-3u1tA:
undetectable		 3g88A-3u1tA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3u1t DMMA HALOALKANE
DEHALOGENASE
(unidentified) 		5 / 11 GLY A 108
ASP A 103
ALA A  62
ALA A 111
ALA A 234
 None
 1.05A 3g88B-3u1tA:
undetectable		 3g88B-3u1tA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3u1t DMMA HALOALKANE
DEHALOGENASE
(unidentified) 		5 / 12 GLY A 108
ASP A 103
ALA A  62
ALA A 111
ALA A 234
 None
 1.09A 3g89A-3u1tA:
undetectable		 3g89A-3u1tA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3u1t DMMA HALOALKANE
DEHALOGENASE
(unidentified) 		5 / 11 GLY A 108
ASP A 103
ALA A  62
ALA A 111
ALA A 234
 None
 1.09A 3g89B-3u1tA:
undetectable		 3g89B-3u1tA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3u1t DMMA HALOALKANE
DEHALOGENASE
(unidentified) 		5 / 12 GLY A 108
ASP A 103
ALA A  62
ALA A 111
ALA A 234
 None
 1.07A 3g8bA-3u1tA:
undetectable		 3g8bA-3u1tA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3u1t DMMA HALOALKANE
DEHALOGENASE
(unidentified) 		5 / 12 GLY A 108
ASP A 103
ALA A  62
ALA A 111
ALA A 234
 None
 1.06A 3g8bB-3u1tA:
undetectable		 3g8bB-3u1tA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3u1t DMMA HALOALKANE
DEHALOGENASE
(unidentified) 		4 / 7 TYR A 117
HIS A 122
LEU A 205
PHE A 236
 None
 1.14A 3jwqC-3u1tA:
undetectable		 3jwqC-3u1tA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 3u1t DMMA HALOALKANE
DEHALOGENASE
(unidentified) 		5 / 9 ASP A 127
ASP A 121
GLY A 146
ILE A 142
PRO A 102
 None
 1.03A 3nu4A-3u1tA:
undetectable		 3nu4A-3u1tA:
15.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 3u1t DMMA HALOALKANE
DEHALOGENASE
(unidentified) 		5 / 8 ASN A  78
ASP A 144
TRP A 145
PHE A 210
HIS A 315
 CL  A 350 (-4.4A)
CL  A 350 ( 4.6A)
CL  A 350 (-4.7A)
CL  A 350 (-4.7A)
MLI  A 351 (-3.3A)
 0.21A 4f5zA-3u1tA:
46.6		 4f5zA-3u1tA:
50.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 3u1t DMMA HALOALKANE
DEHALOGENASE
(unidentified) 		4 / 7 LEU A  73
ILE A  88
ILE A  89
VAL A  92
 None
 0.77A 4ojbA-3u1tA:
undetectable		 4ojbA-3u1tA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 3u1t DMMA HALOALKANE
DEHALOGENASE
(unidentified) 		5 / 10 ASP A 127
ASP A 121
GLY A 146
ILE A 142
PRO A 102
 None
 0.94A 4q1wB-3u1tA:
undetectable		 4q1wB-3u1tA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 3u1t DMMA HALOALKANE
DEHALOGENASE
(unidentified) 		5 / 12 LEU A  84
ILE A  88
ILE A 325
VAL A 220
LEU A 224
 None
 1.24A 4y0pA-3u1tA:
undetectable		 4y0pA-3u1tA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 3u1t DMMA HALOALKANE
DEHALOGENASE
(unidentified) 		5 / 12 ILE A 149
ARG A 155
ALA A 261
ASN A 268
MET A 107
 None
 1.09A 4zo1X-3u1tA:
undetectable		 4zo1X-3u1tA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3u1t DMMA HALOALKANE
DEHALOGENASE
(unidentified) 		4 / 6 PHE A 236
PRO A 244
MET A 107
LEU A 246
 None
 1.45A 5dzka-3u1tA:
undetectable
5dzko-3u1tA:
undetectable		 5dzka-3u1tA:
22.36
5dzko-3u1tA:
0.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3u1t DMMA HALOALKANE
DEHALOGENASE
(unidentified) 		4 / 5 GLU A 168
THR A 314
THR A 213
LEU A 190
 None
MLI  A 351 (-4.0A)
None
None
 1.07A 5hm8A-3u1tA:
2.6		 5hm8A-3u1tA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3u1t DMMA HALOALKANE
DEHALOGENASE
(unidentified) 		4 / 5 GLU A 168
THR A 314
THR A 213
LEU A 190
 None
MLI  A 351 (-4.0A)
None
None
 1.07A 5hm8D-3u1tA:
2.7		 5hm8D-3u1tA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3u1t DMMA HALOALKANE
DEHALOGENASE
(unidentified) 		4 / 5 GLU A 168
THR A 314
THR A 213
LEU A 190
 None
MLI  A 351 (-4.0A)
None
None
 1.06A 5hm8G-3u1tA:
undetectable		 5hm8G-3u1tA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 3u1t DMMA HALOALKANE
DEHALOGENASE
(unidentified) 		5 / 12 ILE A 130
PRO A 102
LEU A  73
SER A 110
GLY A 128
 None
 1.33A 5il1A-3u1tA:
undetectable		 5il1A-3u1tA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3u1t DMMA HALOALKANE
DEHALOGENASE
(unidentified) 		4 / 7 HIS A 315
VAL A 220
GLN A 318
HIS A 321
 MLI  A 351 (-3.3A)
None
None
None
 1.06A 5kkzK-3u1tA:
undetectable
5kkzQ-3u1tA:
undetectable		 5kkzK-3u1tA:
21.09
5kkzQ-3u1tA:
21.90