SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u2h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 3u2h S-LAYER PROTEIN
MA0829
(Methanosarcina
acetivorans) 		3 / 3 ASP A 467
ASP A 469
LYS A 390
 None
 0.94A 1lqtB-3u2hA:
undetectable		 1lqtB-3u2hA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 3u2h S-LAYER PROTEIN
MA0829
(Methanosarcina
acetivorans) 		3 / 3 ASP A 467
ASP A 469
LYS A 390
 None
 0.95A 1lquB-3u2hA:
undetectable		 1lquB-3u2hA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_A_NCAA419_0
(ADP-RIBOSYL CYCLASE)		 3u2h S-LAYER PROTEIN
MA0829
(Methanosarcina
acetivorans) 		4 / 4 VAL A 476
TRP A 367
PHE A 358
TRP A 496
 None
 1.11A 1r15A-3u2hA:
0.0		 1r15A-3u2hA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_B_NCAB429_0
(ADP-RIBOSYL CYCLASE)		 3u2h S-LAYER PROTEIN
MA0829
(Methanosarcina
acetivorans) 		4 / 4 VAL A 476
TRP A 367
PHE A 358
TRP A 496
 None
 1.12A 1r15B-3u2hA:
0.0		 1r15B-3u2hA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 3u2h S-LAYER PROTEIN
MA0829
(Methanosarcina
acetivorans) 		3 / 3 TRP A 367
PHE A 358
TRP A 496
 None
 1.18A 1r15C-3u2hA:
undetectable		 1r15C-3u2hA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD449_0
(ADP-RIBOSYL CYCLASE)		 3u2h S-LAYER PROTEIN
MA0829
(Methanosarcina
acetivorans) 		4 / 4 VAL A 476
TRP A 367
PHE A 358
TRP A 496
 None
 1.14A 1r15D-3u2hA:
0.0		 1r15D-3u2hA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE459_0
(ADP-RIBOSYL CYCLASE)		 3u2h S-LAYER PROTEIN
MA0829
(Methanosarcina
acetivorans) 		4 / 4 VAL A 476
TRP A 367
PHE A 358
TRP A 496
 None
 1.12A 1r15E-3u2hA:
0.0		 1r15E-3u2hA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 3u2h S-LAYER PROTEIN
MA0829
(Methanosarcina
acetivorans) 		3 / 3 TRP A 367
PHE A 358
TRP A 496
 None
 1.19A 1r15F-3u2hA:
undetectable		 1r15F-3u2hA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 3u2h S-LAYER PROTEIN
MA0829
(Methanosarcina
acetivorans) 		3 / 3 TRP A 367
PHE A 358
TRP A 496
 None
 1.20A 1r15G-3u2hA:
undetectable		 1r15G-3u2hA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 3u2h S-LAYER PROTEIN
MA0829
(Methanosarcina
acetivorans) 		3 / 3 TRP A 367
PHE A 358
TRP A 496
 None
 1.20A 1r15H-3u2hA:
undetectable		 1r15H-3u2hA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 3u2h S-LAYER PROTEIN
MA0829
(Methanosarcina
acetivorans) 		4 / 7 PHE A 549
SER A 539
ILE A 551
GLY A 544
 None
 0.96A 2v0mB-3u2hA:
undetectable		 2v0mB-3u2hA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 3u2h S-LAYER PROTEIN
MA0829
(Methanosarcina
acetivorans) 		4 / 6 LEU A 525
THR A 351
PHE A 375
ASP A 510
 None
 1.02A 2wm3A-3u2hA:
undetectable		 2wm3A-3u2hA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 3u2h S-LAYER PROTEIN
MA0829
(Methanosarcina
acetivorans) 		5 / 12 LEU A 525
ILE A 527
SER A 508
PHE A 376
ILE A 391
 None
 1.00A 3lbdA-3u2hA:
undetectable		 3lbdA-3u2hA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3u2h S-LAYER PROTEIN
MA0829
(Methanosarcina
acetivorans) 		4 / 6 ILE A 465
GLU A 466
ALA A 392
ASN A 502
 None
 0.93A 3pgyA-3u2hA:
undetectable
3pgyB-3u2hA:
undetectable		 3pgyA-3u2hA:
22.61
3pgyB-3u2hA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 3u2h S-LAYER PROTEIN
MA0829
(Methanosarcina
acetivorans) 		5 / 10 ASP A 312
GLY A 318
SER A 328
GLY A 374
MET A 373
 None
 1.24A 4xpbA-3u2hA:
undetectable		 4xpbA-3u2hA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 3u2h S-LAYER PROTEIN
MA0829
(Methanosarcina
acetivorans) 		5 / 10 GLY A 318
PHE A 319
SER A 328
GLY A 374
MET A 373
 None
 1.41A 4xpbA-3u2hA:
undetectable		 4xpbA-3u2hA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 3u2h S-LAYER PROTEIN
MA0829
(Methanosarcina
acetivorans) 		3 / 3 GLU A 468
LYS A 390
ASN A 384
 None
 0.91A 4y1dA-3u2hA:
undetectable
4y1dD-3u2hA:
undetectable		 4y1dA-3u2hA:
19.58
4y1dD-3u2hA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3u2h S-LAYER PROTEIN
MA0829
(Methanosarcina
acetivorans) 		5 / 12 PRO A 343
GLY A 345
GLY A 346
LEU A 347
GLU A 530
 None
 0.89A 5c0oF-3u2hA:
undetectable		 5c0oF-3u2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 3u2h S-LAYER PROTEIN
MA0829
(Methanosarcina
acetivorans) 		5 / 11 TYR A 416
ASP A 499
VAL A 460
ALA A 392
ILE A 381
 None
 0.98A 5d75A-3u2hA:
undetectable		 5d75A-3u2hA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 3u2h S-LAYER PROTEIN
MA0829
(Methanosarcina
acetivorans) 		5 / 11 TYR A 416
ASP A 499
VAL A 460
ALA A 392
ILE A 381
 None
 1.07A 5gpgA-3u2hA:
undetectable		 5gpgA-3u2hA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 3u2h S-LAYER PROTEIN
MA0829
(Methanosarcina
acetivorans) 		5 / 12 ILE A 543
LEU A 347
ILE A 551
LEU A 559
GLY A 339
 None
 1.17A 5ienA-3u2hA:
undetectable		 5ienA-3u2hA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 3u2h S-LAYER PROTEIN
MA0829
(Methanosarcina
acetivorans) 		5 / 12 LEU A 525
ILE A 527
SER A 508
PHE A 376
ILE A 391
 None
 1.07A 5m24A-3u2hA:
undetectable		 5m24A-3u2hA:
21.07