SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u3i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		 3u3i NUCLEOCAPSID PROTEIN
(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		4 / 5 PHE A 392
TYR A 311
VAL A 319
VAL A 397
 None
 1.36A 1dz6B-3u3iA:
undetectable		 1dz6B-3u3iA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 3u3i NUCLEOCAPSID PROTEIN
(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		5 / 12 TYR A 311
GLU A  79
ILE A  77
ALA A  75
ASN A 415
 None
 1.15A 1jtxA-3u3iA:
undetectable		 1jtxA-3u3iA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 3u3i NUCLEOCAPSID PROTEIN
(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		4 / 8 SER A 309
TYR A 312
TYR A 110
HIS A 376
 None
 1.28A 2bteD-3u3iA:
undetectable		 2bteD-3u3iA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 3u3i NUCLEOCAPSID PROTEIN
(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		5 / 12 GLY A 340
ASP A  60
GLY A 383
ILE A 385
VAL A  68
 None
 0.94A 2f81B-3u3iA:
undetectable		 2f81B-3u3iA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 3u3i NUCLEOCAPSID PROTEIN
(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		5 / 11 GLY A 340
ASP A  60
GLY A 383
ILE A 385
VAL A  68
 None
 0.79A 2nnpA-3u3iA:
undetectable		 2nnpA-3u3iA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3u3i NUCLEOCAPSID PROTEIN
(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		4 / 7 ILE A 180
ARG A 177
PRO A 118
GLY A 301
 None
 1.20A 2pnjB-3u3iA:
undetectable		 2pnjB-3u3iA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3u3i NUCLEOCAPSID PROTEIN
(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		4 / 6 THR A 323
PHE A 324
LEU A  93
LEU A 314
 None
 1.06A 3bgdA-3u3iA:
undetectable		 3bgdA-3u3iA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3u3i NUCLEOCAPSID PROTEIN
(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		3 / 3 SER A 328
GLN A 329
PHE A 332
 None
 0.81A 3g4lC-3u3iA:
undetectable		 3g4lC-3u3iA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 3u3i NUCLEOCAPSID PROTEIN
(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		5 / 10 GLY A 340
ASP A  60
GLY A 383
ILE A 385
VAL A  68
 None
 0.97A 3oy4B-3u3iA:
undetectable		 3oy4B-3u3iA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_1
(PROTEASE)		 3u3i NUCLEOCAPSID PROTEIN
(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		5 / 12 GLY A 340
ASP A  60
GLY A 383
ILE A 385
VAL A  68
 None
 0.98A 3pwrA-3u3iA:
undetectable		 3pwrA-3u3iA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 3u3i NUCLEOCAPSID PROTEIN
(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		3 / 3 TRP A  95
VAL A  89
TRP A 133
 None
 1.10A 3zq8C-3u3iA:
undetectable
3zq8D-3u3iA:
undetectable		 3zq8C-3u3iA:
3.81
3zq8D-3u3iA:
3.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 3u3i NUCLEOCAPSID PROTEIN
(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		4 / 9 TYR A 260
PHE A 213
ILE A 277
MET A 276
 None
 1.33A 4jvlA-3u3iA:
undetectable		 4jvlA-3u3iA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3u3i NUCLEOCAPSID PROTEIN
(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		3 / 3 LEU A 170
ILE A 174
ARG A 177
 None
 0.70A 4mk4B-3u3iA:
undetectable		 4mk4B-3u3iA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 3u3i NUCLEOCAPSID PROTEIN
(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		5 / 9 GLY A 340
ASP A  60
GLY A 383
ILE A 385
VAL A  68
 None
 0.96A 4q1wA-3u3iA:
undetectable		 4q1wA-3u3iA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 3u3i NUCLEOCAPSID PROTEIN
(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		5 / 10 GLY A 340
ASP A  60
GLY A 383
ILE A 385
VAL A  68
 None
 0.95A 4q1yA-3u3iA:
undetectable		 4q1yA-3u3iA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 3u3i NUCLEOCAPSID PROTEIN
(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		5 / 11 ASP A 305
ARG A 134
PHE A 466
VAL A 390
ILE A  88
 None
 1.17A 5hw8A-3u3iA:
undetectable
5hw8D-3u3iA:
undetectable		 5hw8A-3u3iA:
14.13
5hw8D-3u3iA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 3u3i NUCLEOCAPSID PROTEIN
(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		5 / 9 GLY A 340
ASP A  60
GLY A 383
ILE A 385
VAL A  68
 None
 0.92A 5kr0B-3u3iA:
undetectable		 5kr0B-3u3iA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 3u3i NUCLEOCAPSID PROTEIN
(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		3 / 3 THR A 306
GLU A 387
HIS A 453
 None
 0.92A 5xioA-3u3iA:
undetectable		 5xioA-3u3iA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3u3i NUCLEOCAPSID PROTEIN
(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		3 / 3 THR A 306
GLU A 387
HIS A 453
 None
 0.88A 5xiqD-3u3iA:
undetectable		 5xiqD-3u3iA:
22.04