SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u3z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 3u3z MICROCEPHALIN
(Homo
sapiens) 		4 / 7 GLY A 798
VAL A 816
SER A 768
LEU A 775
 None
 0.62A 2oa1B-3u3zA:
undetectable		 2oa1B-3u3zA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3u3z MICROCEPHALIN
(Homo
sapiens) 		5 / 12 LEU A 695
GLY A 700
TYR A 751
ALA A 736
LEU A 755
 None
 1.34A 3tm4A-3u3zA:
undetectable		 3tm4A-3u3zA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3u3z MICROCEPHALIN
(Homo
sapiens) 		5 / 12 LEU A 695
GLY A 700
TYR A 751
ALA A 736
LEU A 755
 None
 1.32A 3tm4B-3u3zA:
undetectable		 3tm4B-3u3zA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 3u3z MICROCEPHALIN
(Homo
sapiens) 		4 / 7 LEU A 781
THR A 683
THR A 649
LEU A 778
 None
 1.13A 5jq7B-3u3zA:
undetectable		 5jq7B-3u3zA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3u3z MICROCEPHALIN
(Homo
sapiens) 		5 / 12 ALA A 736
GLY A 700
LYS A 824
SER A 819
PRO A 735
 None
 1.36A 5zvgA-3u3zA:
undetectable		 5zvgA-3u3zA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3u3z MICROCEPHALIN
(Homo
sapiens) 		5 / 12 SER A 819
THR A 821
ILE A 820
PHE A 756
LEU A 833
 None
 1.19A 6a93A-3u3zA:
undetectable		 6a93A-3u3zA:
17.60