SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u41'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 3u41 TWIN-ARGININE
LEADER-BINDING
PROTEIN DMSD
(Escherichia
coli) 		3 / 3 ALA A  59
VAL A  57
TRP A  42
 None
 0.85A 1nt6A-3u41A:
undetectable		 1nt6A-3u41A:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 3u41 TWIN-ARGININE
LEADER-BINDING
PROTEIN DMSD
(Escherichia
coli) 		3 / 3 ALA A  59
VAL A  57
TRP A  42
 None
 0.85A 1nt6B-3u41A:
undetectable		 1nt6B-3u41A:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 3u41 TWIN-ARGININE
LEADER-BINDING
PROTEIN DMSD
(Escherichia
coli) 		5 / 12 PHE A  10
ALA A  14
LEU A 186
LEU A 193
LEU A 155
 None
 0.99A 1xdkF-3u41A:
undetectable		 1xdkF-3u41A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1290_1
(FICOLIN-2)		 3u41 TWIN-ARGININE
LEADER-BINDING
PROTEIN DMSD
(Escherichia
coli) 		5 / 9 VAL A  97
LEU A 104
SER A 102
ASP A 126
ARG A 107
 None
 1.31A 2j2pD-3u41A:
undetectable
2j2pE-3u41A:
undetectable		 2j2pD-3u41A:
20.08
2j2pE-3u41A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3u41 TWIN-ARGININE
LEADER-BINDING
PROTEIN DMSD
(Escherichia
coli) 		4 / 5 LEU A 131
ALA A 135
TRP A 189
LEU A 151
 None
 1.25A 2oaxA-3u41A:
undetectable		 2oaxA-3u41A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3u41 TWIN-ARGININE
LEADER-BINDING
PROTEIN DMSD
(Escherichia
coli) 		5 / 12 GLY A 179
ARG A  74
ALA A  71
GLU A  66
ALA A  59
 None
 1.05A 3g89A-3u41A:
undetectable		 3g89A-3u41A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NOS_B_H4BB1011_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 3u41 TWIN-ARGININE
LEADER-BINDING
PROTEIN DMSD
(Escherichia
coli) 		4 / 6 TRP A 158
PHE A 162
VAL A  90
TRP A  87
 None
None
GOL  A 306 (-4.0A)
None
 1.37A 3nosA-3u41A:
0.1
3nosB-3u41A:
0.2		 3nosA-3u41A:
20.85
3nosB-3u41A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3u41 TWIN-ARGININE
LEADER-BINDING
PROTEIN DMSD
(Escherichia
coli) 		4 / 6 VAL A  90
TRP A  87
TRP A 158
PHE A 162
 GOL  A 306 (-4.0A)
None
None
None
 1.43A 4d33A-3u41A:
undetectable
4d33B-3u41A:
undetectable		 4d33A-3u41A:
21.11
4d33B-3u41A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D37_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3u41 TWIN-ARGININE
LEADER-BINDING
PROTEIN DMSD
(Escherichia
coli) 		4 / 6 VAL A  90
TRP A  87
TRP A 158
PHE A 162
 GOL  A 306 (-4.0A)
None
None
None
 1.38A 4d37A-3u41A:
undetectable
4d37B-3u41A:
undetectable		 4d37A-3u41A:
21.11
4d37B-3u41A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3u41 TWIN-ARGININE
LEADER-BINDING
PROTEIN DMSD
(Escherichia
coli) 		4 / 6 VAL A  90
TRP A  87
TRP A 158
PHE A 162
 GOL  A 306 (-4.0A)
None
None
None
 1.37A 4d39A-3u41A:
undetectable
4d39B-3u41A:
undetectable		 4d39A-3u41A:
21.11
4d39B-3u41A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCP_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3u41 TWIN-ARGININE
LEADER-BINDING
PROTEIN DMSD
(Escherichia
coli) 		4 / 6 VAL A  90
TRP A  87
TRP A 158
PHE A 162
 GOL  A 306 (-4.0A)
None
None
None
 1.39A 4kcpA-3u41A:
undetectable
4kcpB-3u41A:
1.0		 4kcpA-3u41A:
21.11
4kcpB-3u41A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCQ_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3u41 TWIN-ARGININE
LEADER-BINDING
PROTEIN DMSD
(Escherichia
coli) 		4 / 6 VAL A  90
TRP A  87
TRP A 158
PHE A 162
 GOL  A 306 (-4.0A)
None
None
None
 1.35A 4kcqA-3u41A:
undetectable
4kcqB-3u41A:
undetectable		 4kcqA-3u41A:
21.11
4kcqB-3u41A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCR_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3u41 TWIN-ARGININE
LEADER-BINDING
PROTEIN DMSD
(Escherichia
coli) 		4 / 6 VAL A  90
TRP A  87
TRP A 158
PHE A 162
 GOL  A 306 (-4.0A)
None
None
None
 1.39A 4kcrA-3u41A:
0.8
4kcrB-3u41A:
undetectable		 4kcrA-3u41A:
21.11
4kcrB-3u41A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCS_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3u41 TWIN-ARGININE
LEADER-BINDING
PROTEIN DMSD
(Escherichia
coli) 		4 / 6 VAL A  90
TRP A  87
TRP A 158
PHE A 162
 GOL  A 306 (-4.0A)
None
None
None
 1.38A 4kcsA-3u41A:
undetectable
4kcsB-3u41A:
undetectable		 4kcsA-3u41A:
21.11
4kcsB-3u41A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV6_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3u41 TWIN-ARGININE
LEADER-BINDING
PROTEIN DMSD
(Escherichia
coli) 		4 / 6 VAL A  90
TRP A  87
TRP A 158
PHE A 162
 GOL  A 306 (-4.0A)
None
None
None
 1.41A 5vv6A-3u41A:
undetectable
5vv6B-3u41A:
undetectable		 5vv6A-3u41A:
21.11
5vv6B-3u41A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 3u41 TWIN-ARGININE
LEADER-BINDING
PROTEIN DMSD
(Escherichia
coli) 		5 / 11 PHE A 166
LEU A 150
ASP A 126
GLY A  88
PHE A 162
 None
 1.25A 6r2eG-3u41A:
undetectable		 6r2eG-3u41A:
21.67