SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u43'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3u43 COLICIN-E2
(Escherichia
coli) 		4 / 6 ARG B 126
GLY B  31
ALA B  26
HIS B 102
 None
None
None
ZN  B 135 (-3.2A)
 0.91A 1wmqA-3u43B:
undetectable		 1wmqA-3u43B:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3u43 COLICIN-E2
(Escherichia
coli) 		4 / 6 ARG B 126
GLY B  31
ALA B  26
HIS B 102
 None
None
None
ZN  B 135 (-3.2A)
 0.92A 1wmqB-3u43B:
undetectable		 1wmqB-3u43B:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3u43 COLICIN-E2
(Escherichia
coli) 		4 / 6 ARG B 126
GLY B  31
ALA B  26
HIS B 102
 None
None
None
ZN  B 135 (-3.2A)
 0.91A 1wpuA-3u43B:
undetectable		 1wpuA-3u43B:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3u43 COLICIN-E2
(Escherichia
coli) 		4 / 6 ARG B 126
GLY B  31
ALA B  26
HIS B 102
 None
None
None
ZN  B 135 (-3.2A)
 0.91A 1wpuB-3u43B:
undetectable		 1wpuB-3u43B:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3u43 COLICIN-E2
(Escherichia
coli) 		4 / 6 ARG B 126
GLY B  31
ALA B  26
HIS B 102
 None
None
None
ZN  B 135 (-3.2A)
 0.91A 1wrqA-3u43B:
undetectable		 1wrqA-3u43B:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3u43 COLICIN-E2
(Escherichia
coli) 		4 / 6 ARG B 126
GLY B  31
ALA B  26
HIS B 102
 None
None
None
ZN  B 135 (-3.2A)
 0.91A 1wrqB-3u43B:
undetectable		 1wrqB-3u43B:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 3u43 COLICIN-E2
(Escherichia
coli) 		4 / 6 ILE B 107
HIS B 102
HIS B 127
HIS B 131
 None
ZN  B 135 (-3.2A)
ZN  B 135 (-3.3A)
ZN  B 135 (-3.4A)
 1.02A 1y93A-3u43B:
undetectable		 1y93A-3u43B:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 3u43 COLICIN-E2
(Escherichia
coli) 		5 / 12 ALA B  26
PRO B  35
GLY B  19
ASP B  25
LEU B  23
 None
 1.27A 2nv4A-3u43B:
undetectable		 2nv4A-3u43B:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3u43 COLICIN-E2
(Escherichia
coli) 		5 / 12 SER B  30
PHE B  50
ARG B 120
ILE B 119
ASN B 118
 None
 1.30A 2vdyA-3u43B:
undetectable		 2vdyA-3u43B:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3u43 COLICIN-E2
(Escherichia
coli) 		5 / 12 SER B  30
PHE B  50
ARG B 120
ILE B 119
ASN B 118
 None
 1.25A 2vdyB-3u43B:
undetectable		 2vdyB-3u43B:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 3u43 COLICIN-E2
(Escherichia
coli) 		4 / 5 ILE B 107
HIS B 102
HIS B 127
HIS B 131
 None
ZN  B 135 (-3.2A)
ZN  B 135 (-3.3A)
ZN  B 135 (-3.4A)
 0.99A 3ljgA-3u43B:
undetectable		 3ljgA-3u43B:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3u43 COLICIN-E2
(Escherichia
coli) 		5 / 12 ALA B  32
ALA B  39
ILE B  34
LEU B  67
GLN B  70
 None
 1.17A 4r38B-3u43B:
undetectable		 4r38B-3u43B:
22.08