SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u4c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 3u4c BACILYSIN
BIOSYNTHESIS
OXIDOREDUCTASE YWFH
(Bacillus
subtilis) 		3 / 3 GLN A 208
TYR A 192
ARG A 191
 None
None
NDP  A 262 (-3.9A)
 0.96A 1gtbA-3u4cA:
undetectable		 1gtbA-3u4cA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 3u4c BACILYSIN
BIOSYNTHESIS
OXIDOREDUCTASE YWFH
(Bacillus
subtilis) 		6 / 12 ILE A  15
LEU A 232
GLY A  14
GLY A  16
THR A 229
LEU A 182
 NDP  A 262 (-3.9A)
None
NDP  A 262 ( 3.7A)
None
None
None
 1.35A 1liiA-3u4cA:
7.7		 1liiA-3u4cA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 3u4c BACILYSIN
BIOSYNTHESIS
OXIDOREDUCTASE YWFH
(Bacillus
subtilis) 		3 / 3 TRP A 144
LEU A 161
LYS A 113
 None
None
NDP  A 262 (-3.1A)
 1.48A 1yajK-3u4cA:
4.4		 1yajK-3u4cA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3u4c BACILYSIN
BIOSYNTHESIS
OXIDOREDUCTASE YWFH
(Bacillus
subtilis) 		4 / 8 PHE A 152
ASN A 154
GLY A  93
THR A 111
 None
 1.02A 1ykiA-3u4cA:
undetectable
1ykiB-3u4cA:
undetectable		 1ykiA-3u4cA:
20.76
1ykiB-3u4cA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3u4c BACILYSIN
BIOSYNTHESIS
OXIDOREDUCTASE YWFH
(Bacillus
subtilis) 		4 / 8 THR A 111
PHE A 152
ASN A 154
GLY A  93
 None
 1.02A 1ykiA-3u4cA:
undetectable
1ykiB-3u4cA:
undetectable		 1ykiA-3u4cA:
20.76
1ykiB-3u4cA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3u4c BACILYSIN
BIOSYNTHESIS
OXIDOREDUCTASE YWFH
(Bacillus
subtilis) 		4 / 8 PHE A 152
ASN A 154
GLY A  93
THR A 111
 None
 1.04A 1ykiC-3u4cA:
undetectable
1ykiD-3u4cA:
undetectable		 1ykiC-3u4cA:
20.76
1ykiD-3u4cA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3u4c BACILYSIN
BIOSYNTHESIS
OXIDOREDUCTASE YWFH
(Bacillus
subtilis) 		4 / 8 THR A 111
PHE A 152
ASN A 154
GLY A  93
 None
 1.00A 1ykiC-3u4cA:
undetectable
1ykiD-3u4cA:
undetectable		 1ykiC-3u4cA:
20.76
1ykiD-3u4cA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3u4c BACILYSIN
BIOSYNTHESIS
OXIDOREDUCTASE YWFH
(Bacillus
subtilis) 		4 / 7 VAL A  56
ILE A  57
LEU A  86
LEU A  83
 None
 1.04A 4l1wA-3u4cA:
undetectable		 4l1wA-3u4cA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3u4c BACILYSIN
BIOSYNTHESIS
OXIDOREDUCTASE YWFH
(Bacillus
subtilis) 		5 / 12 ALA A 237
ALA A  18
ILE A  19
ILE A  47
LEU A  30
 None
 0.96A 4r3aB-3u4cA:
undetectable		 4r3aB-3u4cA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 3u4c BACILYSIN
BIOSYNTHESIS
OXIDOREDUCTASE YWFH
(Bacillus
subtilis) 		4 / 4 ILE A  90
ASN A  88
ILE A 118
VAL A 115
 NDP  A 262 (-4.9A)
None
None
None
 1.12A 4uy87-3u4cA:
undetectable		 4uy87-3u4cA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3u4c BACILYSIN
BIOSYNTHESIS
OXIDOREDUCTASE YWFH
(Bacillus
subtilis) 		4 / 8 THR A   5
LEU A  83
ILE A  76
LEU A 127
 None
 0.87A 5g48A-3u4cA:
undetectable		 5g48A-3u4cA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3u4c BACILYSIN
BIOSYNTHESIS
OXIDOREDUCTASE YWFH
(Bacillus
subtilis) 		6 / 9 VAL A   8
LEU A  23
ALA A  24
PHE A  28
VAL A  85
ILE A  87
 None
 1.28A 5om2A-3u4cA:
undetectable
5om2B-3u4cA:
undetectable		 5om2A-3u4cA:
18.49
5om2B-3u4cA:
12.23