SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u4f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		4 / 5 GLU A   7
THR A   8
HIS A  44
LEU A  52
 None
 1.12A 1d4fC-3u4fA:
undetectable		 1d4fC-3u4fA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		4 / 5 GLU A  68
LEU A  62
LEU A  65
LEU A  63
 None
 1.18A 1np1A-3u4fA:
undetectable		 1np1A-3u4fA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		5 / 12 ALA A  81
GLY A  84
GLY A 264
THR A   8
VAL A  17
 None
 1.12A 2okcA-3u4fA:
undetectable		 2okcA-3u4fA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		4 / 8 LEU A  63
LEU A   3
VAL A  17
GLY A  29
 None
 0.79A 2po5A-3u4fA:
undetectable		 2po5A-3u4fA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		4 / 8 LEU A  63
LEU A   3
VAL A  17
GLY A  29
 None
 0.82A 2po5B-3u4fA:
undetectable		 2po5B-3u4fA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		3 / 3 PRO A  49
LEU A  52
ARG A 365
 None
 0.83A 3aqiB-3u4fA:
undetectable		 3aqiB-3u4fA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		5 / 10 ILE A 334
ALA A 339
THR A 232
ILE A 303
ILE A 265
 None
 1.25A 3prsA-3u4fA:
undetectable		 3prsA-3u4fA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		5 / 12 GLN A 256
GLN A 236
ASP A 183
SER A 118
MET A 119
 None
None
MG  A 371 ( 2.6A)
None
GAI  A 372 ( 3.7A)
 1.29A 3t7sA-3u4fA:
undetectable		 3t7sA-3u4fA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		3 / 3 ARG A 270
MET A 274
ARG A 273
 None
 1.28A 3uvvA-3u4fA:
undetectable		 3uvvA-3u4fA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		5 / 12 GLY A 346
GLY A 348
GLU A 343
ALA A  97
LEU A 104
 None
 0.98A 3vywA-3u4fA:
undetectable		 3vywA-3u4fA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		4 / 6 ASP A 183
GLY A 234
VAL A 255
HIS A 207
 MG  A 371 ( 2.6A)
None
None
None
 1.08A 4oltA-3u4fA:
undetectable		 4oltA-3u4fA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		4 / 6 ASP A 183
GLY A 234
VAL A 255
HIS A 207
 MG  A 371 ( 2.6A)
None
None
None
 1.09A 4oltB-3u4fA:
undetectable		 4oltB-3u4fA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		4 / 5 HIS A 207
VAL A 231
GLU A 209
LYS A 145
 None
None
MG  A 371 ( 2.9A)
GAI  A 372 (-2.7A)
 1.36A 4p6vB-3u4fA:
undetectable
4p6vE-3u4fA:
1.8		 4p6vB-3u4fA:
21.43
4p6vE-3u4fA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		4 / 7 GLU A 209
PHE A 205
LYS A 145
HIS A 207
 MG  A 371 ( 2.9A)
None
GAI  A 372 (-2.7A)
None
 1.23A 4uciB-3u4fA:
undetectable		 4uciB-3u4fA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		3 / 3 ASP A 258
GLU A 209
SER A  36
 None
MG  A 371 ( 2.9A)
None
 0.67A 5bw4B-3u4fA:
undetectable		 5bw4B-3u4fA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		6 / 10 THR A   8
GLU A   7
ALA A  83
GLY A  84
ALA A  88
THR A  87
 None
 1.45A 5lf3H-3u4fA:
undetectable
5lf3I-3u4fA:
undetectable		 5lf3H-3u4fA:
21.16
5lf3I-3u4fA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		6 / 10 THR A   8
GLU A   7
ALA A  83
GLY A  84
ALA A  88
THR A  87
 None
 1.45A 5lf3V-3u4fA:
undetectable
5lf3W-3u4fA:
undetectable		 5lf3V-3u4fA:
21.16
5lf3W-3u4fA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		6 / 11 THR A   8
GLU A   7
ALA A  83
GLY A  84
ALA A  88
THR A  87
 None
 1.46A 5lf7H-3u4fA:
undetectable
5lf7I-3u4fA:
undetectable		 5lf7H-3u4fA:
21.16
5lf7I-3u4fA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		6 / 11 THR A   8
GLU A   7
ALA A  83
GLY A  84
ALA A  88
THR A  87
 None
 1.46A 5lf7V-3u4fA:
undetectable
5lf7W-3u4fA:
undetectable		 5lf7V-3u4fA:
21.16
5lf7W-3u4fA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		4 / 7 ILE A 259
LEU A 299
LEU A 300
PRO A 257
 None
 0.90A 5u4sA-3u4fA:
undetectable		 5u4sA-3u4fA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		4 / 8 ILE A 259
LEU A 299
LEU A 300
PRO A 257
 None
 0.90A 5u4sB-3u4fA:
undetectable		 5u4sB-3u4fA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		5 / 12 SER A 117
MET A 119
THR A 293
TYR A 332
TYR A  34
 GAI  A 372 ( 4.3A)
GAI  A 372 ( 3.7A)
None
None
None
 1.48A 5yf0A-3u4fA:
undetectable		 5yf0A-3u4fA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_B_SAMB503_0
(CARNOSINE
N-METHYLTRANSFERASE)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		5 / 12 SER A 117
MET A 119
THR A 293
TYR A 332
TYR A  34
 GAI  A 372 ( 4.3A)
GAI  A 372 ( 3.7A)
None
None
None
 1.48A 5yf0B-3u4fA:
0.9		 5yf0B-3u4fA:
21.71