SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		4 / 5 ASP A 319
LEU A 279
ALA A  72
LEU A  75
 None
 1.02A 1nh8A-3u4gA:
undetectable		 1nh8A-3u4gA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 11 GLY A 300
GLU A 299
THR A 252
GLY A 227
GLU A 140
 None
 1.31A 2fn1B-3u4gA:
undetectable		 2fn1B-3u4gA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A 204
THR A 148
ALA A 149
LEU A 153
THR A 228
 None
 1.26A 2npnA-3u4gA:
1.1		 2npnA-3u4gA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 214
LEU A 129
VAL A  82
ALA A 225
LEU A 224
 None
 1.19A 2oz7A-3u4gA:
undetectable		 2oz7A-3u4gA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		4 / 8 PRO A 206
THR A 142
PRO A 143
PRO A  37
 None
None
SO4  A 336 (-4.4A)
None
 0.86A 2v32C-3u4gA:
undetectable
2v32D-3u4gA:
undetectable		 2v32C-3u4gA:
23.16
2v32D-3u4gA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		4 / 8 PRO A 206
THR A 142
PRO A 143
PRO A  37
 None
None
SO4  A 336 (-4.4A)
None
 0.89A 2v41C-3u4gA:
undetectable
2v41D-3u4gA:
undetectable		 2v41C-3u4gA:
23.16
2v41D-3u4gA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		4 / 8 PRO A  37
PRO A 206
THR A 142
PRO A 143
 None
None
None
SO4  A 336 (-4.4A)
 0.86A 2v41C-3u4gA:
undetectable
2v41D-3u4gA:
undetectable		 2v41C-3u4gA:
23.16
2v41D-3u4gA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		4 / 8 PRO A  37
PRO A 206
THR A 142
PRO A 143
 None
None
None
SO4  A 336 (-4.4A)
 0.79A 2v41G-3u4gA:
undetectable
2v41H-3u4gA:
undetectable		 2v41G-3u4gA:
23.16
2v41H-3u4gA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 10 ALA A  66
ALA A 303
THR A 307
LEU A 279
VAL A 320
 None
 1.36A 2wuzA-3u4gA:
undetectable		 2wuzA-3u4gA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 9 ALA A  41
VAL A 301
ILE A  35
PRO A 143
THR A 142
 None
None
None
SO4  A 336 (-4.4A)
None
 1.02A 3el4B-3u4gA:
undetectable		 3el4B-3u4gA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 124
LEU A  81
VAL A  96
LEU A 129
ILE A 132
 None
 1.12A 3gwxB-3u4gA:
undetectable		 3gwxB-3u4gA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  12
THR A 142
GLY A 139
ALA A  66
LEU A  44
 None
 1.11A 3p5nA-3u4gA:
undetectable		 3p5nA-3u4gA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  12
THR A 142
GLY A 139
ALA A  66
LEU A  44
 None
 1.11A 3p5nB-3u4gA:
undetectable		 3p5nB-3u4gA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 12 VAL A  11
ASP A 205
SER A 234
LEU A 237
THR A 142
 None
 1.13A 3qfxA-3u4gA:
undetectable		 3qfxA-3u4gA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 12 VAL A  11
ASP A 205
SER A 234
LEU A 237
THR A 142
 None
 1.10A 3qfxB-3u4gA:
undetectable		 3qfxB-3u4gA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 11 ILE A  80
GLY A 302
ALA A 303
THR A 307
VAL A 320
 None
 1.08A 3rukD-3u4gA:
undetectable		 3rukD-3u4gA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 9 ALA A  41
VAL A 301
ILE A  35
PRO A 143
THR A 142
 None
None
None
SO4  A 336 (-4.4A)
None
 0.93A 3spkA-3u4gA:
undetectable		 3spkA-3u4gA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A  41
VAL A 301
ILE A  35
PRO A 143
THR A 142
 None
None
None
SO4  A 336 (-4.4A)
None
 0.94A 3spkB-3u4gA:
undetectable		 3spkB-3u4gA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		4 / 5 THR A 147
ILE A 178
LYS A 174
GLU A 175
 None
 1.41A 4ac9C-3u4gA:
2.6		 4ac9C-3u4gA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		4 / 5 THR A 147
ILE A 178
LYS A 174
GLU A 175
 None
 1.41A 4acaC-3u4gA:
2.5		 4acaC-3u4gA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		4 / 5 THR A 147
ILE A 178
LYS A 174
GLU A 175
 None
 1.45A 4acbC-3u4gA:
undetectable		 4acbC-3u4gA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 289
GLY A 300
ALA A  66
VAL A 297
ASP A  40
 None
None
None
None
ACY  A 338 ( 4.2A)
 0.97A 4dc3A-3u4gA:
undetectable		 4dc3A-3u4gA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A 125
ILE A 138
THR A 210
GLY A 213
 None
 0.97A 4eq4A-3u4gA:
undetectable		 4eq4A-3u4gA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A 125
ILE A 138
THR A 210
GLY A 213
 None
 0.96A 4eqlA-3u4gA:
1.5		 4eqlA-3u4gA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A 125
ILE A 138
THR A 210
GLY A 213
 None
 0.96A 4eqlB-3u4gA:
1.4		 4eqlB-3u4gA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		4 / 6 LEU A 125
ILE A 138
THR A 210
GLY A 213
 None
 0.94A 4l39A-3u4gA:
1.6		 4l39A-3u4gA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A  41
VAL A 301
ILE A  35
PRO A 143
THR A 142
 None
None
None
SO4  A 336 (-4.4A)
None
 0.96A 4njuA-3u4gA:
undetectable		 4njuA-3u4gA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A  41
VAL A 301
ILE A  35
PRO A 143
THR A 142
 None
None
None
SO4  A 336 (-4.4A)
None
 0.97A 4njuC-3u4gA:
undetectable		 4njuC-3u4gA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 9 ILE A 138
VAL A 137
GLY A 302
THR A 307
SER A  76
 None
 1.22A 4r20B-3u4gA:
undetectable		 4r20B-3u4gA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 12 ARG A 104
SER A  18
GLY A 144
ALA A 209
GLY A 204
 None
None
SO4  A 336 (-3.3A)
None
None
 1.04A 4r29C-3u4gA:
undetectable		 4r29C-3u4gA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		4 / 4 ALA A  41
VAL A  11
GLY A  86
THR A  87
 None
 1.05A 4ubeA-3u4gA:
4.8		 4ubeA-3u4gA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A 214
PHE A   8
GLY A  85
LEU A  12
LEU A 125
 None
 1.20A 4wnuA-3u4gA:
undetectable		 4wnuA-3u4gA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		4 / 7 ASP A 105
ARG A 107
GLY A 181
GLU A 180
 ACY  A 339 (-3.7A)
ACY  A 339 (-4.1A)
None
ACY  A 339 (-4.4A)
 0.88A 5bs8A-3u4gA:
undetectable
5bs8C-3u4gA:
undetectable
5bs8D-3u4gA:
undetectable		 5bs8A-3u4gA:
23.48
5bs8C-3u4gA:
23.48
5bs8D-3u4gA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		4 / 7 ASP A 105
ARG A 107
GLY A 181
GLU A 180
 ACY  A 339 (-3.7A)
ACY  A 339 (-4.1A)
None
ACY  A 339 (-4.4A)
 0.89A 5btaA-3u4gA:
undetectable
5btaC-3u4gA:
undetectable
5btaD-3u4gA:
undetectable		 5btaA-3u4gA:
23.29
5btaC-3u4gA:
23.29
5btaD-3u4gA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		4 / 7 ASP A 105
ARG A 107
GLY A 181
GLU A 180
 ACY  A 339 (-3.7A)
ACY  A 339 (-4.1A)
None
ACY  A 339 (-4.4A)
 0.86A 5btfA-3u4gA:
undetectable
5btfB-3u4gA:
undetectable
5btfC-3u4gA:
undetectable		 5btfA-3u4gA:
23.29
5btfB-3u4gA:
22.97
5btfC-3u4gA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		4 / 7 ASP A 105
ARG A 107
GLY A 181
GLU A 180
 ACY  A 339 (-3.7A)
ACY  A 339 (-4.1A)
None
ACY  A 339 (-4.4A)
 0.79A 5btfA-3u4gA:
undetectable
5btfC-3u4gA:
undetectable
5btfD-3u4gA:
undetectable		 5btfA-3u4gA:
23.29
5btfC-3u4gA:
23.29
5btfD-3u4gA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		4 / 6 SER A 215
GLU A 242
GLY A 302
GLY A 226
 None
 0.81A 5cdnA-3u4gA:
undetectable
5cdnB-3u4gA:
undetectable		 5cdnA-3u4gA:
21.82
5cdnB-3u4gA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		4 / 6 PHE A  45
HIS A  95
PRO A  94
LEU A  92
 None
 1.39A 5dzka-3u4gA:
undetectable
5dzko-3u4gA:
undetectable		 5dzka-3u4gA:
21.36
5dzko-3u4gA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 7 PHE A  45
ALA A  41
HIS A  95
PRO A  94
LEU A  92
 None
 1.38A 5dzkD-3u4gA:
2.1
5dzkR-3u4gA:
undetectable		 5dzkD-3u4gA:
21.36
5dzkR-3u4gA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 10 THR A  69
GLU A 135
ALA A 303
GLY A 304
ALA A 225
 None
 1.18A 5lf3H-3u4gA:
undetectable
5lf3I-3u4gA:
undetectable		 5lf3H-3u4gA:
21.16
5lf3I-3u4gA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 10 THR A  69
GLU A 135
ALA A 303
GLY A 304
ALA A 225
 None
 1.20A 5lf3V-3u4gA:
undetectable
5lf3W-3u4gA:
undetectable		 5lf3V-3u4gA:
21.16
5lf3W-3u4gA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 178
ALA A 151
PHE A 106
PRO A  30
 None
 0.94A 5m0oC-3u4gA:
undetectable		 5m0oC-3u4gA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A 153
GLY A 157
GLY A 190
LEU A 236
ALA A 235
 None
 1.05A 5o96C-3u4gA:
2.2
5o96D-3u4gA:
undetectable		 5o96C-3u4gA:
18.90
5o96D-3u4gA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A 153
GLY A 157
GLY A 190
LEU A 236
ALA A 235
 None
 1.09A 5o96E-3u4gA:
2.1
5o96F-3u4gA:
undetectable		 5o96E-3u4gA:
18.90
5o96F-3u4gA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 306
PRO A  56
TYR A 292
ALA A 303
GLY A 302
 None
ACY  A 338 ( 4.7A)
None
None
None
 1.15A 5tzoA-3u4gA:
undetectable		 5tzoA-3u4gA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 306
PRO A  56
TYR A 292
ALA A 303
GLY A 302
 None
ACY  A 338 ( 4.7A)
None
None
None
 1.10A 5tzoC-3u4gA:
undetectable		 5tzoC-3u4gA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 249
MET A 248
GLY A 305
ALA A  72
PHE A  78
 None
 1.05A 5zw4A-3u4gA:
undetectable		 5zw4A-3u4gA:
23.34