SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u4t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BXO_A_SAMA238_1 (N,N-DIMETHYLTRANSFER ASE)	3u4t	TPR REPEAT-CONTAINING PROTEIN (Cytophaga hutchinsonii)	3 / 3	TYR A 244 GLU A 303 ASP A 329	None	0.77A	3bxoA-3u4tA: undetectable	3bxoA-3u4tA: 21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BXO_B_SAMB238_1 (N,N-DIMETHYLTRANSFER ASE)	3u4t	TPR REPEAT-CONTAINING PROTEIN (Cytophaga hutchinsonii)	3 / 3	TYR A 244 GLU A 303 ASP A 329	None	0.87A	3bxoB-3u4tA: undetectable	3bxoB-3u4tA: 21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OU6_C_SAMC300_1 (SAM-DEPENDENT METHYLTRANSFERASE)	3u4t	TPR REPEAT-CONTAINING PROTEIN (Cytophaga hutchinsonii)	3 / 3	TYR A 455 GLY A 421 ASP A 415	None	0.58A	3ou6C-3u4tA: undetectable	3ou6C-3u4tA: 21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YV5_A_SVRA205_1 (BASIC PHOSPHOLIPASE A2 HOMOLOG 2)	3u4t	TPR REPEAT-CONTAINING PROTEIN (Cytophaga hutchinsonii)	4 / 7	ASN A 266 TYR A 273 TYR A 278 LEU A 280	None	1.17A	4yv5A-3u4tA: undetectable	4yv5A-3u4tA: 18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FSE_C_HQEC1583_1 (UREASE SUBUNIT ALPHA)	3u4t	TPR REPEAT-CONTAINING PROTEIN (Cytophaga hutchinsonii)	4 / 5	ILE A 248 ARG A 268 CYH A 271 GLU A 274	None	1.19A	5fseC-3u4tA: undetectable	5fseC-3u4tA: 18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HA9_B_TP0B406_1 (POLY [ADP-RIBOSE] POLYMERASE 1)	3u4t	TPR REPEAT-CONTAINING PROTEIN (Cytophaga hutchinsonii)	5 / 9	GLU A 428 ASN A 471 ILE A 472 TYR A 451 TYR A 456	None	1.25A	5ha9B-3u4tA: undetectable	5ha9B-3u4tA: 20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LSU_B_SAMB1304_1 (HISTONE-LYSINE N-METHYLTRANSFERASE NSD2)	3u4t	TPR REPEAT-CONTAINING PROTEIN (Cytophaga hutchinsonii)	3 / 3	ASN A 399 TYR A 404 CYH A 434	None	0.83A	5lsuB-3u4tA: undetectable	5lsuB-3u4tA: 16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NOO_C_D16C402_1 (THYMIDYLATE SYNTHASE)	3u4t	TPR REPEAT-CONTAINING PROTEIN (Cytophaga hutchinsonii)	5 / 6	TYR A 378 LEU A 405 GLY A 403 PHE A 390 TYR A 441	None	1.41A	5nooC-3u4tA: undetectable	5nooC-3u4tA: 21.36

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3BXO_A_SAMA238_1","N,N-DIMETHYLTRANSFERASE","3u4t","TPR REPEAT-CONTAINING PROTEIN","Cytophaga hutchinsonii",3,"TYR A 244;GLU A 303;ASP A 329","None","0.77A","3bxoA-3u4tA:undetectable","3bxoA-3u4tA:21.20"],["3BXO_B_SAMB238_1","N,N-DIMETHYLTRANSFERASE","3u4t","TPR REPEAT-CONTAINING PROTEIN","Cytophaga hutchinsonii",3,"TYR A 244;GLU A 303;ASP A 329","None","0.87A","3bxoB-3u4tA:undetectable","3bxoB-3u4tA:21.20"],["3OU6_C_SAMC300_1","SAM-DEPENDENT METHYLTRANSFERASE","3u4t","TPR REPEAT-CONTAINING PROTEIN","Cytophaga hutchinsonii",3,"TYR A 455;GLY A 421;ASP A 415","None","0.58A","3ou6C-3u4tA:undetectable","3ou6C-3u4tA:21.48"],["4YV5_A_SVRA205_1","BASIC PHOSPHOLIPASE A2 HOMOLOG 2","3u4t","TPR REPEAT-CONTAINING PROTEIN","Cytophaga hutchinsonii",4,"ASN A 266;TYR A 273;TYR A 278;LEU A 280","None","1.17A","4yv5A-3u4tA:undetectable","4yv5A-3u4tA:18.38"],["5FSE_C_HQEC1583_1","UREASE SUBUNIT ALPHA","3u4t","TPR REPEAT-CONTAINING PROTEIN","Cytophaga hutchinsonii",4,"ILE A 248;ARG A 268;CYH A 271;GLU A 274","None","1.19A","5fseC-3u4tA:undetectable","5fseC-3u4tA:18.32"],["5HA9_B_TP0B406_1","POLY [ADP-RIBOSE] POLYMERASE 1","3u4t","TPR REPEAT-CONTAINING PROTEIN","Cytophaga hutchinsonii",5,"GLU A 428;ASN A 471;ILE A 472;TYR A 451;TYR A 456","None","1.25A","5ha9B-3u4tA:undetectable","5ha9B-3u4tA:20.10"],["5LSU_B_SAMB1304_1","HISTONE-LYSINE N-METHYLTRANSFERASE NSD2","3u4t","TPR REPEAT-CONTAINING PROTEIN","Cytophaga hutchinsonii",3,"ASN A 399;TYR A 404;CYH A 434","None","0.83A","5lsuB-3u4tA:undetectable","5lsuB-3u4tA:16.84"],["5NOO_C_D16C402_1","THYMIDYLATE SYNTHASE","3u4t","TPR REPEAT-CONTAINING PROTEIN","Cytophaga hutchinsonii",5,"TYR A 378;LEU A 405;GLY A 403;PHE A 390;TYR A 441","None","1.41A","5nooC-3u4tA:undetectable","5nooC-3u4tA:21.36"]]