SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u4y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3u4y UNCHARACTERIZED
PROTEIN
(Desulfotomaculum
acetoxidans) 		4 / 5 THR A 231
GLU A 281
THR A 280
LEU A 284
 None
 1.14A 1d4fC-3u4yA:
undetectable		 1d4fC-3u4yA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3u4y UNCHARACTERIZED
PROTEIN
(Desulfotomaculum
acetoxidans) 		5 / 12 ILE A 178
VAL A  98
ALA A 127
ILE A 123
ILE A 121
 None
 1.00A 1epbB-3u4yA:
undetectable		 1epbB-3u4yA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3u4y UNCHARACTERIZED
PROTEIN
(Desulfotomaculum
acetoxidans) 		5 / 12 VAL A  11
GLY A 315
ASN A 313
GLY A 100
VAL A  53
 None
 1.12A 1jg4A-3u4yA:
undetectable		 1jg4A-3u4yA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3u4y UNCHARACTERIZED
PROTEIN
(Desulfotomaculum
acetoxidans) 		5 / 12 ILE A 142
ASP A 163
LYS A 154
ILE A 208
LEU A 139
 None
 1.30A 1rh3A-3u4yA:
undetectable		 1rh3A-3u4yA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3u4y UNCHARACTERIZED
PROTEIN
(Desulfotomaculum
acetoxidans) 		5 / 12 ALA A 127
ILE A 123
ALA A 131
LEU A 139
PHE A 153
 None
 1.10A 1udtA-3u4yA:
undetectable		 1udtA-3u4yA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3u4y UNCHARACTERIZED
PROTEIN
(Desulfotomaculum
acetoxidans) 		5 / 10 ALA A 127
ILE A 123
ALA A 131
LEU A 139
PHE A 153
 None
 1.16A 1xp0A-3u4yA:
undetectable		 1xp0A-3u4yA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 3u4y UNCHARACTERIZED
PROTEIN
(Desulfotomaculum
acetoxidans) 		5 / 9 ALA A 190
VAL A 234
ILE A 199
VAL A 225
ILE A 223
 None
 0.99A 2o4pB-3u4yA:
undetectable		 2o4pB-3u4yA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3u4y UNCHARACTERIZED
PROTEIN
(Desulfotomaculum
acetoxidans) 		4 / 6 THR A  54
THR A  42
THR A  45
ASP A  91
 None
 1.10A 2okcB-3u4yA:
undetectable		 2okcB-3u4yA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 3u4y UNCHARACTERIZED
PROTEIN
(Desulfotomaculum
acetoxidans) 		5 / 9 ASP A 143
ILE A 197
GLY A 171
ILE A 169
ILE A 178
 None
 1.16A 2r5qA-3u4yA:
undetectable		 2r5qA-3u4yA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 3u4y UNCHARACTERIZED
PROTEIN
(Desulfotomaculum
acetoxidans) 		5 / 9 ASP A 143
ILE A 197
GLY A 171
ILE A 169
ILE A 178
 None
 1.16A 2r5qC-3u4yA:
undetectable		 2r5qC-3u4yA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 3u4y UNCHARACTERIZED
PROTEIN
(Desulfotomaculum
acetoxidans) 		5 / 10 ASP A  85
GLY A 271
ALA A 272
ILE A 316
ILE A 223
 None
 1.00A 3el9B-3u4yA:
undetectable		 3el9B-3u4yA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 3u4y UNCHARACTERIZED
PROTEIN
(Desulfotomaculum
acetoxidans) 		3 / 3 HIS A  15
ARG A 292
GLU A  13
 None
 1.18A 3qf1A-3u4yA:
undetectable		 3qf1A-3u4yA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 3u4y UNCHARACTERIZED
PROTEIN
(Desulfotomaculum
acetoxidans) 		4 / 6 GLN A  67
PHE A  21
PRO A  71
LEU A  30
 None
 1.36A 3tgvB-3u4yA:
undetectable		 3tgvB-3u4yA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 3u4y UNCHARACTERIZED
PROTEIN
(Desulfotomaculum
acetoxidans) 		5 / 12 ILE A 142
ILE A 208
GLN A 166
ILE A 140
THR A 149
 None
None
TRS  A 330 (-4.9A)
None
None
 1.00A 4m2xG-3u4yA:
undetectable		 4m2xG-3u4yA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3u4y UNCHARACTERIZED
PROTEIN
(Desulfotomaculum
acetoxidans) 		4 / 5 ASN A 177
GLY A 129
ASP A  92
ASP A  41
 None
 0.98A 4n48B-3u4yA:
undetectable		 4n48B-3u4yA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3u4y UNCHARACTERIZED
PROTEIN
(Desulfotomaculum
acetoxidans) 		4 / 4 ASN A 177
GLY A 129
ASP A  92
ASP A  41
 None
 1.07A 4n49A-3u4yA:
undetectable		 4n49A-3u4yA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 3u4y UNCHARACTERIZED
PROTEIN
(Desulfotomaculum
acetoxidans) 		5 / 11 ILE A 142
ASP A 163
LYS A 154
ILE A 208
LEU A 139
 None
 1.24A 4qi9C-3u4yA:
undetectable		 4qi9C-3u4yA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 3u4y UNCHARACTERIZED
PROTEIN
(Desulfotomaculum
acetoxidans) 		3 / 3 PRO A 182
ILE A 142
SER A 226
 None
 0.74A 5fsaA-3u4yA:
undetectable		 5fsaA-3u4yA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 3u4y UNCHARACTERIZED
PROTEIN
(Desulfotomaculum
acetoxidans) 		5 / 12 LEU A 139
PHE A 180
ILE A 208
THR A 149
GLY A 129
 None
 1.06A 5veuH-3u4yA:
undetectable		 5veuH-3u4yA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 3u4y UNCHARACTERIZED
PROTEIN
(Desulfotomaculum
acetoxidans) 		4 / 4 VAL A  11
ALA A 317
PHE A  22
PHE A   8
 None
 1.45A 6cbdA-3u4yA:
undetectable		 6cbdA-3u4yA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 3u4y UNCHARACTERIZED
PROTEIN
(Desulfotomaculum
acetoxidans) 		4 / 4 VAL A  11
ALA A 317
PHE A  22
PHE A  21
 None
 1.48A 6cbdA-3u4yA:
undetectable		 6cbdA-3u4yA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 3u4y UNCHARACTERIZED
PROTEIN
(Desulfotomaculum
acetoxidans) 		3 / 3 LEU A 141
LEU A 139
ARG A 152
 None
 0.65A 6fgdA-3u4yA:
undetectable		 6fgdA-3u4yA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 3u4y UNCHARACTERIZED
PROTEIN
(Desulfotomaculum
acetoxidans) 		4 / 4 LEU A 192
ASP A 265
PRO A 266
ARG A 267
 None
 0.88A 6fgdA-3u4yA:
undetectable		 6fgdA-3u4yA:
21.98