SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u50'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3u50 TELOMERASE-ASSOCIATE
D PROTEIN 82
(Tetrahymena
thermophila) 		3 / 3 LEU C 673
LEU C 587
MET C 586
 None
 0.87A 2itzA-3u50C:
undetectable		 2itzA-3u50C:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 3u50 TELOMERASE-ASSOCIATE
D PROTEIN 82
(Tetrahymena
thermophila) 		5 / 8 ILE C 611
LEU C 610
LEU C 585
LEU C 587
LEU C 646
 None
 1.48A 4zvcA-3u50C:
undetectable
4zvcB-3u50C:
undetectable		 4zvcA-3u50C:
21.05
4zvcB-3u50C:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 3u50 TELOMERASE-ASSOCIATE
D PROTEIN 82
(Tetrahymena
thermophila) 		5 / 8 LEU C 587
LEU C 646
ILE C 611
LEU C 610
LEU C 585
 None
 1.48A 4zvcA-3u50C:
undetectable
4zvcB-3u50C:
undetectable		 4zvcA-3u50C:
21.05
4zvcB-3u50C:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3u50 TELOMERASE-ASSOCIATE
D PROTEIN 82
(Tetrahymena
thermophila) 		4 / 7 ILE C 513
VAL C 591
ILE C 520
PHE C 653
 None
 0.93A 5hieC-3u50C:
undetectable		 5hieC-3u50C:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 3u50 TELOMERASE-ASSOCIATE
D PROTEIN 82
(Tetrahymena
thermophila) 		3 / 3 GLY C 559
CYH C 557
CYH C 555
 None
ZN  C 684 (-1.3A)
ZN  C 684 (-2.6A)
 0.84A 5inzB-3u50C:
undetectable		 5inzB-3u50C:
9.09