SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		4 / 5 SER A 138
THR A 139
GLU A 160
GLY A 158
 None
 1.18A 1icrA-3u5tA:
undetectable
1icrB-3u5tA:
undetectable		 1icrA-3u5tA:
24.82
1icrB-3u5tA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		4 / 5 GLU A 160
GLY A 158
SER A 138
THR A 139
 None
 1.17A 1icrA-3u5tA:
undetectable
1icrB-3u5tA:
undetectable		 1icrA-3u5tA:
24.82
1icrB-3u5tA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		4 / 5 SER A 138
THR A 139
GLU A 160
GLY A 158
 None
 1.17A 1icvC-3u5tA:
undetectable
1icvD-3u5tA:
undetectable		 1icvC-3u5tA:
24.82
1icvD-3u5tA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		4 / 5 GLU A 160
GLY A 158
SER A 138
THR A 139
 None
 1.17A 1icvC-3u5tA:
undetectable
1icvD-3u5tA:
undetectable		 1icvC-3u5tA:
24.82
1icvD-3u5tA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		4 / 5 GLU A 160
GLY A 158
SER A 138
THR A 139
 None
 1.16A 1kqbA-3u5tA:
undetectable
1kqbB-3u5tA:
undetectable		 1kqbA-3u5tA:
23.78
1kqbB-3u5tA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		4 / 6 GLU A 160
GLY A 158
SER A 138
THR A 139
 None
 1.17A 1kqbC-3u5tA:
undetectable
1kqbD-3u5tA:
undetectable		 1kqbC-3u5tA:
23.78
1kqbD-3u5tA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A  20
ALA A  19
GLY A  15
ILE A 217
GLY A  11
 None
 0.79A 2qe6A-3u5tA:
6.1		 2qe6A-3u5tA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A  20
ALA A  19
GLY A  15
ILE A 217
GLY A  11
 None
 0.86A 2qe6B-3u5tA:
6.1		 2qe6B-3u5tA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		4 / 7 GLU A  50
ILE A  33
ALA A 225
ILE A 135
 None
 0.80A 2xkwA-3u5tA:
undetectable		 2xkwA-3u5tA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 11 ASN A  89
VAL A  87
ILE A  20
GLY A 219
ILE A 135
 None
 1.03A 3lzvB-3u5tA:
undetectable		 3lzvB-3u5tA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 131
VAL A  85
ALA A 124
ALA A 125
LEU A 170
 None
 0.97A 3mteA-3u5tA:
5.6		 3mteA-3u5tA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 131
VAL A  85
ALA A 124
ALA A 125
LEU A 170
 None
 0.97A 3mteB-3u5tA:
5.9		 3mteB-3u5tA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 ALA A   7
ASP A  84
GLY A  28
VAL A 221
ALA A  21
 None
 0.95A 3n3iA-3u5tA:
undetectable		 3n3iA-3u5tA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 11 GLY A 132
ASN A 178
LEU A 170
LEU A  86
LEU A 128
 None
 1.38A 3ndvA-3u5tA:
undetectable
3ndvB-3u5tA:
undetectable		 3ndvA-3u5tA:
23.18
3ndvB-3u5tA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 11 LEU A  86
LEU A 128
GLY A 132
ASN A 178
LEU A 170
 None
 1.33A 3ndvA-3u5tA:
undetectable
3ndvB-3u5tA:
undetectable		 3ndvA-3u5tA:
23.18
3ndvB-3u5tA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 11 GLY A 132
ASN A 178
LEU A 170
LEU A  86
LEU A 128
 None
 1.34A 3ndvC-3u5tA:
undetectable
3ndvD-3u5tA:
undetectable		 3ndvC-3u5tA:
23.18
3ndvD-3u5tA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 11 LEU A  86
LEU A 128
GLY A 132
ASN A 178
LEU A 170
 None
 1.38A 3ndvC-3u5tA:
undetectable
3ndvD-3u5tA:
undetectable		 3ndvC-3u5tA:
23.18
3ndvD-3u5tA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 131
VAL A  85
ALA A 124
ALA A 125
LEU A 170
 None
 0.96A 3p2kC-3u5tA:
5.1		 3p2kC-3u5tA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 131
VAL A  85
ALA A 124
ALA A 125
LEU A 170
 None
 0.97A 3p2kD-3u5tA:
5.6		 3p2kD-3u5tA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		3 / 3 LYS A 168
VAL A 165
HIS A 164
 None
 1.23A 3tj7A-3u5tA:
undetectable		 3tj7A-3u5tA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		4 / 6 ASP A  62
GLY A 116
VAL A 112
THR A  10
 None
 1.17A 3vqrA-3u5tA:
3.2		 3vqrA-3u5tA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		4 / 5 ASP A  62
GLY A 116
VAL A 112
THR A  10
 None
 1.18A 3vqrB-3u5tA:
6.0		 3vqrB-3u5tA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 11 ASN A 240
MET A 137
ASN A 178
SER A 140
GLY A 219
 None
 1.41A 4a6nC-3u5tA:
6.2		 4a6nC-3u5tA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC391_1
(TETX2 PROTEIN)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 11 ASN A 240
MET A 137
ASN A 178
SER A 140
GLY A 219
 None
 1.41A 4a99C-3u5tA:
5.9		 4a99C-3u5tA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		4 / 8 GLY A  47
ILE A  49
ILE A  33
THR A  58
 None
 0.86A 4em2A-3u5tA:
undetectable		 4em2A-3u5tA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		4 / 5 GLY A 116
SER A  64
ALA A 111
PHE A 118
 None
 1.05A 4m93B-3u5tA:
undetectable
4m93C-3u5tA:
undetectable		 4m93B-3u5tA:
21.98
4m93C-3u5tA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		4 / 8 GLY A  91
ALA A  90
GLY A  17
ILE A  16
 None
 0.67A 5kr1B-3u5tA:
undetectable		 5kr1B-3u5tA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A  20
PRO A 182
VAL A 221
GLY A 219
ASP A 216
 None
 1.19A 5nnaC-3u5tA:
undetectable		 5nnaC-3u5tA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A  33
PHE A  73
ARG A  71
ALA A  68
LEU A  72
 None
 1.28A 5oy02-3u5tA:
undetectable		 5oy02-3u5tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 226
ALA A 225
VAL A  87
ILE A  20
VAL A  85
 None
 0.94A 6dh0A-3u5tA:
undetectable		 6dh0A-3u5tA:
16.10