SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u5u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		4 / 7 TYR A 257
PHE A 261
GLY A 267
GLY A 264
 None
 0.74A 11gsB-3u5uA:
undetectable		 11gsB-3u5uA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		5 / 12 ILE A 271
TYR A 339
LEU A 335
SER A 338
PHE A 154
 None
 1.07A 1fmlB-3u5uA:
undetectable		 1fmlB-3u5uA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		4 / 5 TYR A 240
ILE A 371
ARG A 323
GLY A 236
 None
 1.33A 1kifA-3u5uA:
undetectable		 1kifA-3u5uA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		4 / 5 TYR A 240
ILE A 371
ARG A 323
GLY A 236
 None
 1.32A 1kifB-3u5uA:
undetectable		 1kifB-3u5uA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		4 / 5 TYR A 240
ILE A 371
ARG A 323
GLY A 236
 None
 1.33A 1kifC-3u5uA:
undetectable		 1kifC-3u5uA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		4 / 5 TYR A 240
ILE A 371
ARG A 323
GLY A 236
 None
 1.33A 1kifD-3u5uA:
undetectable		 1kifD-3u5uA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		4 / 5 TYR A 240
ILE A 371
ARG A 323
GLY A 236
 None
 1.33A 1kifE-3u5uA:
undetectable		 1kifE-3u5uA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		4 / 5 TYR A 240
ILE A 371
ARG A 323
GLY A 236
 None
 1.33A 1kifF-3u5uA:
undetectable		 1kifF-3u5uA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		4 / 5 TYR A 240
ILE A 371
ARG A 323
GLY A 236
 None
 1.33A 1kifG-3u5uA:
undetectable		 1kifG-3u5uA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		4 / 5 TYR A 240
ILE A 371
ARG A 323
GLY A 236
 None
 1.32A 1kifH-3u5uA:
undetectable		 1kifH-3u5uA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		5 / 12 LEU A 123
TYR A 119
LEU A  85
LEU A 471
TYR A  93
 None
 1.35A 1p33B-3u5uA:
2.0		 1p33B-3u5uA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		5 / 12 LEU A 123
TYR A 119
LEU A  85
LEU A 471
TYR A  93
 None
 1.35A 1p33C-3u5uA:
undetectable		 1p33C-3u5uA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		5 / 12 GLY A 106
GLY A 105
GLY A 110
PHE A 163
SER A 100
 None
 1.07A 1wg8A-3u5uA:
undetectable		 1wg8A-3u5uA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		5 / 12 GLY A 106
GLY A 105
GLY A 111
PHE A 163
SER A 100
 None
 1.21A 1wg8A-3u5uA:
undetectable		 1wg8A-3u5uA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		5 / 12 GLY A 106
GLY A 105
GLY A 110
PHE A 163
SER A 100
 None
 1.11A 1wg8B-3u5uA:
undetectable		 1wg8B-3u5uA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		5 / 12 GLY A 106
GLY A 105
GLY A 111
PHE A 163
SER A 100
 None
 1.11A 1wg8B-3u5uA:
undetectable		 1wg8B-3u5uA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOW_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		4 / 7 GLU A 420
GLN A 186
TYR A 200
TRP A 392
 None
 1.29A 2aowA-3u5uA:
1.3		 2aowA-3u5uA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		5 / 12 ILE A  62
ALA A  71
GLY A 480
SER A  74
ASN A  67
 None
 1.12A 2okcA-3u5uA:
undetectable		 2okcA-3u5uA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		5 / 12 ILE A  62
ALA A  71
GLY A 480
SER A  74
ASN A  67
 None
 1.15A 2okcB-3u5uA:
undetectable		 2okcB-3u5uA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		3 / 3 ARG A 401
GLU A 398
GLN A 455
 None
 0.90A 2p16A-3u5uA:
undetectable		 2p16A-3u5uA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		5 / 12 LEU A 155
GLU A 238
ARG A 204
ALA A 201
PHE A 190
 None
 1.35A 3apwB-3u5uA:
undetectable		 3apwB-3u5uA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		4 / 4 GLY A 194
GLY A 198
GLY A 205
GLY A 203
 None
 0.59A 3bogC-3u5uA:
undetectable		 3bogC-3u5uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		4 / 4 GLY A 194
GLY A 198
GLY A 205
GLY A 203
 None
 0.47A 3bogD-3u5uA:
undetectable		 3bogD-3u5uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		5 / 10 ARG A  42
GLY A  39
ALA A  71
TYR A  35
HIS A  56
 None
 1.24A 3boyA-3u5uA:
undetectable
3boyC-3u5uA:
undetectable		 3boyA-3u5uA:
14.31
3boyC-3u5uA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		5 / 10 TYR A  35
HIS A  56
ARG A  42
GLY A  39
ALA A  71
 None
 1.24A 3boyA-3u5uA:
undetectable
3boyB-3u5uA:
undetectable		 3boyA-3u5uA:
14.31
3boyB-3u5uA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA3001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		5 / 10 TYR A  35
HIS A  56
ARG A  42
GLY A  39
ALA A  71
 None
 1.23A 3boyB-3u5uA:
undetectable
3boyC-3u5uA:
undetectable		 3boyB-3u5uA:
14.31
3boyC-3u5uA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		4 / 5 ILE A  17
MET A 508
ASN A  87
PHE A  22
 None
 1.25A 3octA-3u5uA:
undetectable		 3octA-3u5uA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		4 / 7 ASP A 142
ILE A  37
VAL A  72
TYR A 481
 None
 1.08A 3p6hA-3u5uA:
undetectable		 3p6hA-3u5uA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		5 / 9 LEU A 404
ASP A 448
GLY A 422
ILE A 403
ILE A 400
 None
 1.02A 3s56B-3u5uA:
undetectable		 3s56B-3u5uA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		4 / 7 GLY A  39
ASP A  69
GLY A  68
HIS A  56
 None
 0.77A 4c5nA-3u5uA:
2.9		 4c5nA-3u5uA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		4 / 8 GLY A  39
ASP A  69
GLY A  68
HIS A  56
 None
 0.74A 4c5nC-3u5uA:
2.5		 4c5nC-3u5uA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		3 / 3 ASP A 142
TRP A 469
SER A  96
 None
 0.98A 4lrhB-3u5uA:
undetectable		 4lrhB-3u5uA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		3 / 3 ASP A 142
TRP A 469
SER A  96
 None
 1.07A 4lrhF-3u5uA:
undetectable		 4lrhF-3u5uA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		4 / 6 ASP A  69
ASP A  52
SER A  98
ALA A  71
 None
 0.99A 4nedA-3u5uA:
undetectable		 4nedA-3u5uA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		4 / 8 TYR A 200
THR A 197
TRP A 392
PHE A 485
 None
 1.19A 4tzcB-3u5uA:
undetectable
4tzcD-3u5uA:
undetectable		 4tzcB-3u5uA:
11.18
4tzcD-3u5uA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		3 / 3 ASN A 185
PHE A 467
TYR A  93
 None
 0.68A 4u15A-3u5uA:
undetectable		 4u15A-3u5uA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		3 / 3 LEU A 256
VAL A 160
ASP A 161
 None
 0.49A 4y8wC-3u5uA:
undetectable		 4y8wC-3u5uA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		5 / 12 TYR A  78
TYR A  35
ASP A  73
ALA A  71
TYR A 481
 None
 1.27A 4ymgB-3u5uA:
undetectable		 4ymgB-3u5uA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE
(Rauvolfia
serpentina) 		4 / 6 TRP A  99
LEU A 248
TYR A 151
GLN A 145
 None
 1.28A 6djzC-3u5uA:
undetectable		 6djzC-3u5uA:
19.21