SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u5z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3u5z DNA POLYMERASE
ACCESSORY PROTEIN 44
(Escherichia
virus
T4) 		5 / 12 THR B 207
ASP B 203
GLY B  55
GLY B  53
LEU B  25
 None
None
08T  B 700 (-3.1A)
08T  B 700 (-3.0A)
None
 1.11A 1rjdA-3u5zB:
undetectable		 1rjdA-3u5zB:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3u5z DNA POLYMERASE
ACCESSORY PROTEIN 44
(Escherichia
virus
T4) 		5 / 12 THR B 207
ASP B 203
GLY B  55
GLY B  53
LEU B  25
 None
None
08T  B 700 (-3.1A)
08T  B 700 (-3.0A)
None
 1.09A 1rjdB-3u5zB:
2.9		 1rjdB-3u5zB:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3u5z DNA POLYMERASE
ACCESSORY PROTEIN 44
(Escherichia
virus
T4) 		6 / 12 THR B 207
ASP B 203
GLY B  55
GLY B  53
SER B  51
LEU B  25
 None
None
08T  B 700 (-3.1A)
08T  B 700 (-3.0A)
None
None
 1.41A 1rjdC-3u5zB:
3.0		 1rjdC-3u5zB:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 3u5z DNA POLYMERASE
ACCESSORY PROTEIN 44
(Escherichia
virus
T4) 		4 / 4 LEU B 211
SER B 215
TYR B 214
LEU B 196
 None
 1.24A 1xz1A-3u5zB:
undetectable		 1xz1A-3u5zB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 3u5z DNA POLYMERASE
ACCESSORY PROTEIN 44
(Escherichia
virus
T4) 		4 / 4 LEU B 211
SER B 215
TYR B 214
LEU B 196
 None
 1.26A 1xz3A-3u5zB:
undetectable		 1xz3A-3u5zB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 3u5z DNA POLYMERASE
ACCESSORY PROTEIN 44
(Escherichia
virus
T4) 		5 / 12 ALA B 138
ILE B 106
VAL B 105
ILE B  45
ILE B 144
 None
 0.89A 3ekqA-3u5zB:
undetectable		 3ekqA-3u5zB:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 3u5z DNA POLYMERASE
PROCESSIVITY
COMPONENT
(Escherichia
virus
T4) 		4 / 7 LEU G5169
LEU G5126
LEU G5123
ILE G5182
 None
 0.82A 4ubsA-3u5zG:
undetectable		 4ubsA-3u5zG:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 3u5z DNA POLYMERASE
ACCESSORY PROTEIN 44
(Escherichia
virus
T4) 		5 / 12 VAL B 288
ILE B 235
LEU B 242
LEU B 250
PHE B 264
 None
 1.18A 5im2A-3u5zB:
undetectable		 5im2A-3u5zB:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3u5z DNA POLYMERASE
PROCESSIVITY
COMPONENT
(Escherichia
virus
T4) 		3 / 3 VAL G5218
ARG G5128
PRO G5191
 None
 0.77A 5koxA-3u5zG:
undetectable		 5koxA-3u5zG:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EUQ_A_DXCA502_0
(MULTIDRUG
TRANSPORTER MDFA)		 3u5z DNA POLYMERASE
ACCESSORY PROTEIN 44
(Escherichia
virus
T4) 		5 / 11 TYR B 257
LEU B 242
GLY B 233
PRO B 255
LEU B 250
 None
 1.33A 6euqA-3u5zB:
undetectable		 6euqA-3u5zB:
20.27