SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u62'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 3u62 SHIKIMATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 6 LEU A 157
GLU A 162
ASP A 161
PRO A 184
 None
 1.23A 1ditH-3u62A:
undetectable
1ditP-3u62A:
undetectable		 1ditH-3u62A:
23.67
1ditP-3u62A:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 3u62 SHIKIMATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 6 LEU A 190
ALA A 210
LEU A 193
SER A 194
 None
 0.96A 1tz8C-3u62A:
undetectable
1tz8D-3u62A:
undetectable		 1tz8C-3u62A:
23.38
1tz8D-3u62A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 3u62 SHIKIMATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 7 VAL A 137
VAL A 123
ASN A 139
GLY A 115
 None
None
SO4  A 503 (-3.8A)
SO4  A 503 (-3.5A)
 0.98A 3kmoB-3u62A:
undetectable		 3kmoB-3u62A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3u62 SHIKIMATE
DEHYDROGENASE
(Thermotoga
maritima) 		3 / 3 TYR A  91
ASP A  75
ASP A  94
 None
 0.98A 3ou7B-3u62A:
4.3		 3ou7B-3u62A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 3u62 SHIKIMATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 7 PHE A  23
HIS A  30
ILE A 238
ASN A  57
 None
 1.10A 4o7gA-3u62A:
undetectable
4o7gB-3u62A:
undetectable		 4o7gA-3u62A:
20.00
4o7gB-3u62A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3u62 SHIKIMATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 9 ALA A 126
GLY A 117
GLY A 118
ALA A 119
ASP A  94
 None
SO4  A 501 (-4.3A)
SO4  A 501 (-3.2A)
None
None
 1.07A 4qvmK-3u62A:
undetectable
4qvmL-3u62A:
undetectable		 4qvmK-3u62A:
20.83
4qvmL-3u62A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3u62 SHIKIMATE
DEHYDROGENASE
(Thermotoga
maritima) 		3 / 3 ALA A 229
ASN A 232
LEU A 233
 None
 0.51A 5i1oA-3u62A:
undetectable		 5i1oA-3u62A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 3u62 SHIKIMATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 ILE A  14
PHE A 225
LEU A 252
PHE A 244
ILE A   5
 SO4  A 500 (-4.0A)
None
None
None
None
 1.07A 6dwnC-3u62A:
undetectable		 6dwnC-3u62A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3u62 SHIKIMATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 LEU A 128
GLY A 131
ILE A 124
VAL A 113
ILE A 135
 None
 1.00A 6emuA-3u62A:
3.4		 6emuA-3u62A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 3u62 SHIKIMATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 10 ARG A  65
VAL A  66
GLY A   7
GLY A  55
VAL A  85
 None
 1.11A 6eu9B-3u62A:
undetectable		 6eu9B-3u62A:
17.90