SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u67'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3u67 HEAT SHOCK PROTEIN
83-1
(Leishmania
major) 		5 / 12 ASN A  36
ASP A  39
ASP A  78
MET A  83
THR A 169
 MG  A 215 ( 2.5A)
None
ADP  A 214 (-3.6A)
ADP  A 214 (-3.5A)
ADP  A 214 (-3.6A)
 0.86A 1s14A-3u67A:
10.3		 1s14A-3u67A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3u67 HEAT SHOCK PROTEIN
83-1
(Leishmania
major) 		4 / 6 LEU A 205
ARG A 170
THR A 172
LEU A  74
 None
 1.06A 1v54A-3u67A:
undetectable
1v54J-3u67A:
undetectable		 1v54A-3u67A:
18.22
1v54J-3u67A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3u67 HEAT SHOCK PROTEIN
83-1
(Leishmania
major) 		4 / 6 LEU A 205
ARG A 170
THR A 172
LEU A  74
 None
 1.06A 2dysN-3u67A:
undetectable
2dysW-3u67A:
undetectable		 2dysN-3u67A:
18.22
2dysW-3u67A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3u67 HEAT SHOCK PROTEIN
83-1
(Leishmania
major) 		4 / 6 LEU A 205
ARG A 170
THR A 172
LEU A  74
 None
 1.05A 2eijA-3u67A:
undetectable
2eijJ-3u67A:
undetectable		 2eijA-3u67A:
18.22
2eijJ-3u67A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3u67 HEAT SHOCK PROTEIN
83-1
(Leishmania
major) 		4 / 6 LEU A 205
ARG A 170
THR A 172
LEU A  74
 None
 1.02A 2eilA-3u67A:
undetectable
2eilJ-3u67A:
undetectable		 2eilA-3u67A:
18.22
2eilJ-3u67A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 3u67 HEAT SHOCK PROTEIN
83-1
(Leishmania
major) 		4 / 7 LEU A 173
ILE A 171
ASN A  36
PHE A 123
 None
None
MG  A 215 ( 2.5A)
None
 0.92A 2opxA-3u67A:
undetectable		 2opxA-3u67A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3u67 HEAT SHOCK PROTEIN
83-1
(Leishmania
major) 		4 / 6 LEU A 205
ARG A 170
THR A 172
LEU A  74
 None
 1.11A 2zxwA-3u67A:
undetectable
2zxwJ-3u67A:
undetectable		 2zxwA-3u67A:
18.22
2zxwJ-3u67A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 3u67 HEAT SHOCK PROTEIN
83-1
(Leishmania
major) 		5 / 12 ASN A  36
ASP A  39
ASP A  78
MET A  83
THR A 169
 MG  A 215 ( 2.5A)
None
ADP  A 214 (-3.6A)
ADP  A 214 (-3.5A)
ADP  A 214 (-3.6A)
 0.79A 3lpsA-3u67A:
11.7		 3lpsA-3u67A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 3u67 HEAT SHOCK PROTEIN
83-1
(Leishmania
major) 		3 / 3 ARG A 187
LEU A 191
GLU A 190
 None
 0.71A 4l3gF-3u67A:
undetectable		 4l3gF-3u67A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3u67 HEAT SHOCK PROTEIN
83-1
(Leishmania
major) 		5 / 11 ASN A  36
ASP A  39
ASP A  78
MET A  83
THR A 169
 MG  A 215 ( 2.5A)
None
ADP  A 214 (-3.6A)
ADP  A 214 (-3.5A)
ADP  A 214 (-3.6A)
 0.75A 4urnA-3u67A:
11.9		 4urnA-3u67A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3u67 HEAT SHOCK PROTEIN
83-1
(Leishmania
major) 		5 / 11 ASN A  36
ASP A  39
ASP A  78
MET A  83
THR A 169
 MG  A 215 ( 2.5A)
None
ADP  A 214 (-3.6A)
ADP  A 214 (-3.5A)
ADP  A 214 (-3.6A)
 0.82A 4urnC-3u67A:
11.8		 4urnC-3u67A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3u67 HEAT SHOCK PROTEIN
83-1
(Leishmania
major) 		3 / 3 THR A 160
SER A 163
ASP A 142
 EDO  A 216 (-3.5A)
EDO  A 216 (-4.1A)
None
 0.75A 5kvaA-3u67A:
undetectable		 5kvaA-3u67A:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3u67 HEAT SHOCK PROTEIN
83-1
(Leishmania
major) 		3 / 3 THR A 160
SER A 163
ASP A 142
 EDO  A 216 (-3.5A)
EDO  A 216 (-4.1A)
None
 0.77A 5kvaB-3u67A:
undetectable		 5kvaB-3u67A:
25.68