SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u6n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN
(Danio
rerio) 		5 / 12 PHE A 919
LEU A 507
ALA A 508
SER A 926
PHE A 511
 None
 1.27A 1kglA-3u6nA:
undetectable		 1kglA-3u6nA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN
(Danio
rerio) 		5 / 11 LEU A 499
ALA A 495
VAL A 981
LEU A1056
LEU A 944
 None
 1.14A 1rlbF-3u6nA:
undetectable		 1rlbF-3u6nA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN
(Danio
rerio) 		5 / 11 ALA A 914
ILE A 883
LEU A 907
ALA A 920
VAL A 923
 None
 1.19A 1rv7A-3u6nA:
undetectable
1rv7B-3u6nA:
undetectable		 1rv7A-3u6nA:
9.54
1rv7B-3u6nA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN
(Danio
rerio) 		5 / 11 ILE A 708
VAL A 742
LEU A 719
ALA A 714
VAL A 796
 None
 1.03A 1rv7A-3u6nA:
undetectable
1rv7B-3u6nA:
undetectable		 1rv7A-3u6nA:
9.54
1rv7B-3u6nA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN
(Danio
rerio) 		4 / 5 GLY A 916
GLN A 501
VAL A1037
SER A 504
 None
 1.37A 1zzqB-3u6nA:
undetectable		 1zzqB-3u6nA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN
(Danio
rerio) 		4 / 5 GLY A 916
GLN A 501
VAL A1037
SER A 504
 None
 1.35A 1zzuA-3u6nA:
1.1		 1zzuA-3u6nA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN
(Danio
rerio) 		5 / 12 LEU A 927
ILE A 937
ILE A 566
MET A 536
PHE A 511
 None
 0.79A 2ygoA-3u6nA:
undetectable		 2ygoA-3u6nA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN
(Danio
rerio) 		5 / 12 LEU A 927
ILE A 937
ILE A 566
MET A 536
PHE A 511
 None
 0.91A 2ygqA-3u6nA:
undetectable		 2ygqA-3u6nA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN
(Danio
rerio) 		4 / 4 LEU A 507
MET A 513
ILE A 583
ASP A 482
 None
 1.35A 3hecA-3u6nA:
undetectable		 3hecA-3u6nA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN
(Danio
rerio) 		5 / 9 ILE A 566
LEU A 503
PHE A 493
ARG A 942
GLY A 492
 None
 1.40A 3nxuB-3u6nA:
undetectable		 3nxuB-3u6nA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN
(Danio
rerio) 		5 / 12 VAL A 723
LEU A 503
GLY A 492
ALA A 495
LEU A 745
 None
 1.18A 3pghA-3u6nA:
undetectable		 3pghA-3u6nA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN
(Danio
rerio) 		4 / 4 LEU A 598
GLY A 599
LEU A 541
GLU A 539
 None
 1.04A 3tgvB-3u6nA:
undetectable		 3tgvB-3u6nA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN
(Danio
rerio) 		3 / 3 GLY A 531
THR A1039
ASN A 509
 None
 0.56A 3v4tD-3u6nA:
2.0		 3v4tD-3u6nA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN
(Danio
rerio) 		5 / 11 PHE A 493
LEU A 940
ILE A 937
LEU A 510
LEU A 503
 None
 1.11A 4dm8A-3u6nA:
undetectable		 4dm8A-3u6nA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN
(Danio
rerio) 		4 / 5 TYR A1019
GLN A 501
GLY A 502
SER A 504
 None
 0.77A 4fu8A-3u6nA:
undetectable		 4fu8A-3u6nA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN
(Danio
rerio) 		4 / 8 MET A 536
PHE A 511
LEU A 927
PHE A 696
 None
 0.98A 4rkuA-3u6nA:
undetectable
4rkuJ-3u6nA:
undetectable		 4rkuA-3u6nA:
21.37
4rkuJ-3u6nA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN
(Danio
rerio) 		5 / 12 VAL A 723
LEU A 503
GLY A 492
ALA A 495
LEU A 745
 None
 1.09A 5iktB-3u6nA:
0.3		 5iktB-3u6nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN
(Danio
rerio) 		5 / 12 PHE A 919
LEU A 507
ALA A 508
SER A 926
PHE A 511
 None
 1.33A 5ljbA-3u6nA:
undetectable		 5ljbA-3u6nA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN
(Danio
rerio) 		5 / 12 ILE A 424
THR A 458
GLN A 459
VAL A 921
VAL A 923
 None
 1.25A 6bzoC-3u6nA:
undetectable		 6bzoC-3u6nA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN
(Danio
rerio) 		3 / 3 LYS A 361
SER A 929
SER A 926
 None
 0.84A 6gbfA-3u6nA:
undetectable		 6gbfA-3u6nA:
20.57