SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u78'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 3u78 LYSINE-SPECIFIC
DEMETHYLASE 7
(Homo
sapiens) 		4 / 8 ASN A 372
LEU A 435
ALA A 438
LEU A 439
 None
 0.83A 1hwiD-3u78A:
undetectable		 1hwiD-3u78A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 3u78 LYSINE-SPECIFIC
DEMETHYLASE 7
(Homo
sapiens) 		4 / 7 PRO A 424
LEU A 428
GLY A 431
LEU A 414
 None
 0.82A 1ya4B-3u78A:
undetectable		 1ya4B-3u78A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3u78 LYSINE-SPECIFIC
DEMETHYLASE 7
(Homo
sapiens) 		5 / 12 PHE A 285
VAL A 290
ALA A 355
PHE A 281
TYR A 314
 E67  A 707 (-4.3A)
None
None
None
None
 1.31A 2g72A-3u78A:
undetectable		 2g72A-3u78A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 3u78 LYSINE-SPECIFIC
DEMETHYLASE 7
(Homo
sapiens) 		4 / 5 ASP A 308
LEU A 311
MET A 384
ARG A 380
 None
 1.15A 2gj5A-3u78A:
undetectable		 2gj5A-3u78A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 3u78 LYSINE-SPECIFIC
DEMETHYLASE 7
(Homo
sapiens) 		5 / 8 LEU A 311
ILE A 353
PHE A 281
ARG A 313
GLY A 329
 None
None
None
SO4  A 704 (-4.0A)
None
 1.02A 3b9lA-3u78A:
2.8		 3b9lA-3u78A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_1
(PHOSPHOLIPASE A2)		 3u78 LYSINE-SPECIFIC
DEMETHYLASE 7
(Homo
sapiens) 		4 / 4 SER A 174
PRO A 175
PHE A 177
PRO A 173
 None
 1.31A 3bjwA-3u78A:
0.0		 3bjwA-3u78A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_2
(PHOSPHOLIPASE A2)		 3u78 LYSINE-SPECIFIC
DEMETHYLASE 7
(Homo
sapiens) 		4 / 4 SER A 174
PRO A 175
PHE A 177
PRO A 173
 None
 1.34A 3bjwG-3u78A:
0.0		 3bjwG-3u78A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_1
(PHOSPHOLIPASE A2)		 3u78 LYSINE-SPECIFIC
DEMETHYLASE 7
(Homo
sapiens) 		4 / 4 SER A 174
PRO A 175
PHE A 177
PRO A 173
 None
 1.33A 3bjwD-3u78A:
0.0		 3bjwD-3u78A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_A_DMOA551_1
(ARGINASE-1)		 3u78 LYSINE-SPECIFIC
DEMETHYLASE 7
(Homo
sapiens) 		5 / 9 HIS A 282
ASP A 284
SER A 227
ASP A 392
THR A 279
 NI  A 702 ( 3.4A)
NI  A 702 (-2.6A)
None
E67  A 707 (-3.4A)
AKG  A 701 (-3.6A)
 1.47A 3gn0A-3u78A:
undetectable		 3gn0A-3u78A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 3u78 LYSINE-SPECIFIC
DEMETHYLASE 7
(Homo
sapiens) 		4 / 7 TYR A 382
GLU A 450
TRP A 442
LEU A 379
 None
 1.32A 3k8mA-3u78A:
undetectable		 3k8mA-3u78A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 3u78 LYSINE-SPECIFIC
DEMETHYLASE 7
(Homo
sapiens) 		4 / 7 TYR A 382
GLU A 450
TRP A 442
LEU A 379
 None
 1.26A 3k8mB-3u78A:
undetectable		 3k8mB-3u78A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 3u78 LYSINE-SPECIFIC
DEMETHYLASE 7
(Homo
sapiens) 		6 / 10 LEU A 271
THR A 279
HIS A 282
ASP A 284
LYS A 299
HIS A 354
 None
AKG  A 701 (-3.6A)
NI  A 702 ( 3.4A)
NI  A 702 (-2.6A)
AKG  A 701 (-3.2A)
NI  A 702 ( 3.5A)
 0.91A 3kcxA-3u78A:
16.2		 3kcxA-3u78A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 3u78 LYSINE-SPECIFIC
DEMETHYLASE 7
(Homo
sapiens) 		4 / 7 HIS A 354
ALA A 355
VAL A 356
ALA A 117
 NI  A 702 ( 3.5A)
None
AKG  A 701 (-4.1A)
None
 0.70A 4g77A-3u78A:
undetectable		 4g77A-3u78A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3u78 LYSINE-SPECIFIC
DEMETHYLASE 7
(Homo
sapiens) 		4 / 5 LEU A 271
ASP A 284
GLU A 229
VAL A 241
 None
NI  A 702 (-2.6A)
None
None
 0.90A 4nkvA-3u78A:
undetectable		 4nkvA-3u78A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_B_ACTB201_0
(RETINOL-BINDING
PROTEIN 2)		 3u78 LYSINE-SPECIFIC
DEMETHYLASE 7
(Homo
sapiens) 		4 / 5 TYR A 254
TYR A 427
GLU A 152
GLN A 148
 None
 1.41A 4qztB-3u78A:
undetectable		 4qztB-3u78A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 3u78 LYSINE-SPECIFIC
DEMETHYLASE 7
(Homo
sapiens) 		4 / 4 CYH A 403
LEU A 379
LEU A 435
ALA A 434
 None
 0.97A 5hpuA-3u78A:
undetectable
5hpuB-3u78A:
undetectable		 5hpuA-3u78A:
5.35
5hpuB-3u78A:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 3u78 LYSINE-SPECIFIC
DEMETHYLASE 7
(Homo
sapiens) 		3 / 3 VAL A 432
LYS A 440
MET A 443
 None
 0.82A 5nknA-3u78A:
undetectable		 5nknA-3u78A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 3u78 LYSINE-SPECIFIC
DEMETHYLASE 7
(Homo
sapiens) 		5 / 12 VAL A 179
VAL A 356
PHE A 214
GLN A 200
ILE A 300
 None
AKG  A 701 (-4.1A)
None
E67  A 707 (-3.3A)
None
 1.37A 6becA-3u78A:
undetectable
6becB-3u78A:
undetectable
6becC-3u78A:
undetectable		 6becA-3u78A:
21.05
6becB-3u78A:
21.05
6becC-3u78A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 3u78 LYSINE-SPECIFIC
DEMETHYLASE 7
(Homo
sapiens) 		5 / 12 LEU A 165
GLY A 143
ILE A 244
VAL A 162
ILE A 160
 None
 1.03A 6ectA-3u78A:
undetectable		 6ectA-3u78A:
22.00