SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u7g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 3u7g BIFUNCTIONAL
POLYNUCLEOTIDE
PHOSPHATASE/KINASE
(Mus
musculus) 		5 / 10 PHE A 231
VAL A 250
VAL A 235
VAL A 238
LEU A 175
 None
 1.14A 1fe2A-3u7gA:
undetectable		 1fe2A-3u7gA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 3u7g BIFUNCTIONAL
POLYNUCLEOTIDE
PHOSPHATASE/KINASE
(Mus
musculus) 		3 / 3 PHE A 340
TYR A 516
PRO A 342
 GOL  A   1 (-4.4A)
None
GOL  A   1 (-3.5A)
 0.81A 1mcnA-3u7gA:
undetectable
1mcnB-3u7gA:
undetectable
1mcnP-3u7gA:
undetectable		 1mcnA-3u7gA:
21.52
1mcnB-3u7gA:
21.52
1mcnP-3u7gA:
1.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 3u7g BIFUNCTIONAL
POLYNUCLEOTIDE
PHOSPHATASE/KINASE
(Mus
musculus) 		4 / 5 ILE A 193
PHE A 246
VAL A 316
PHE A 326
 None
None
None
GOL  A 527 ( 4.3A)
 1.17A 2ygnA-3u7gA:
undetectable		 2ygnA-3u7gA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 3u7g BIFUNCTIONAL
POLYNUCLEOTIDE
PHOSPHATASE/KINASE
(Mus
musculus) 		4 / 8 ASP A 266
VAL A 213
PHE A 312
LEU A 318
 None
 1.06A 4f8hA-3u7gA:
undetectable
4f8hB-3u7gA:
undetectable		 4f8hA-3u7gA:
22.79
4f8hB-3u7gA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 3u7g BIFUNCTIONAL
POLYNUCLEOTIDE
PHOSPHATASE/KINASE
(Mus
musculus) 		4 / 8 ASP A 266
VAL A 213
PHE A 312
LEU A 318
 None
 1.07A 4f8hB-3u7gA:
undetectable
4f8hC-3u7gA:
undetectable		 4f8hB-3u7gA:
22.79
4f8hC-3u7gA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 3u7g BIFUNCTIONAL
POLYNUCLEOTIDE
PHOSPHATASE/KINASE
(Mus
musculus) 		4 / 8 ASP A 266
VAL A 213
PHE A 312
LEU A 318
 None
 1.05A 4f8hC-3u7gA:
undetectable
4f8hD-3u7gA:
undetectable		 4f8hC-3u7gA:
22.79
4f8hD-3u7gA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 3u7g BIFUNCTIONAL
POLYNUCLEOTIDE
PHOSPHATASE/KINASE
(Mus
musculus) 		4 / 8 ASP A 266
VAL A 213
PHE A 312
LEU A 318
 None
 1.06A 4f8hD-3u7gA:
undetectable
4f8hE-3u7gA:
undetectable		 4f8hD-3u7gA:
22.79
4f8hE-3u7gA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 3u7g BIFUNCTIONAL
POLYNUCLEOTIDE
PHOSPHATASE/KINASE
(Mus
musculus) 		4 / 8 VAL A 213
PHE A 312
LEU A 318
ASP A 266
 None
 1.05A 4f8hA-3u7gA:
undetectable
4f8hE-3u7gA:
undetectable		 4f8hA-3u7gA:
22.79
4f8hE-3u7gA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 3u7g BIFUNCTIONAL
POLYNUCLEOTIDE
PHOSPHATASE/KINASE
(Mus
musculus) 		5 / 10 ALA A 369
PHE A 449
GLU A 499
PHE A 380
LEU A 351
 None
 1.38A 4la0A-3u7gA:
undetectable		 4la0A-3u7gA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_B_198B601_1
(SERUM ALBUMIN)		 3u7g BIFUNCTIONAL
POLYNUCLEOTIDE
PHOSPHATASE/KINASE
(Mus
musculus) 		5 / 9 ALA A 369
PHE A 449
GLU A 499
PHE A 380
LEU A 351
 None
 1.35A 4la0B-3u7gA:
undetectable		 4la0B-3u7gA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 3u7g BIFUNCTIONAL
POLYNUCLEOTIDE
PHOSPHATASE/KINASE
(Mus
musculus) 		3 / 3 ARG A 445
TYR A 390
GLU A 365
 None
 0.63A 4zzbE-3u7gA:
undetectable		 4zzbE-3u7gA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 3u7g BIFUNCTIONAL
POLYNUCLEOTIDE
PHOSPHATASE/KINASE
(Mus
musculus) 		4 / 7 LEU A 202
THR A 322
ASP A 309
LEU A 242
 None
None
MG  A 529 ( 4.5A)
None
 1.04A 5jq7B-3u7gA:
undetectable		 5jq7B-3u7gA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3u7g BIFUNCTIONAL
POLYNUCLEOTIDE
PHOSPHATASE/KINASE
(Mus
musculus) 		5 / 12 ASP A 266
ALA A 251
PHE A 312
LEU A 318
VAL A 316
 None
 1.06A 5tudA-3u7gA:
undetectable		 5tudA-3u7gA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3u7g BIFUNCTIONAL
POLYNUCLEOTIDE
PHOSPHATASE/KINASE
(Mus
musculus) 		5 / 12 ASP A 266
ALA A 251
PHE A 312
LEU A 318
VAL A 316
 None
 1.06A 5tudD-3u7gA:
undetectable		 5tudD-3u7gA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3u7g BIFUNCTIONAL
POLYNUCLEOTIDE
PHOSPHATASE/KINASE
(Mus
musculus) 		3 / 3 SER A 520
HIS A 458
TYR A 516
 GOL  A   1 (-2.4A)
GOL  A   1 (-3.4A)
None
 1.04A 5y2tA-3u7gA:
undetectable		 5y2tA-3u7gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 3u7g BIFUNCTIONAL
POLYNUCLEOTIDE
PHOSPHATASE/KINASE
(Mus
musculus) 		3 / 3 PRO A 354
SER A 356
SER A 357
 None
 0.69A 6bpyA-3u7gA:
undetectable		 6bpyA-3u7gA:
24.14