SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u7i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 3u7i FMN-DEPENDENT
NADH-AZOREDUCTASE 1
(Bacillus
anthracis) 		5 / 12 ILE A   6
LEU A 110
PHE A  24
TYR A 179
MET A 141
 None
 1.04A 1hvyD-3u7iA:
undetectable		 1hvyD-3u7iA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 3u7i FMN-DEPENDENT
NADH-AZOREDUCTASE 1
(Bacillus
anthracis) 		3 / 3 GLU A 161
HIS A 164
ASP A 154
 None
CL  A 222 (-4.8A)
None
 0.60A 1i9gA-3u7iA:
undetectable		 1i9gA-3u7iA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3u7i FMN-DEPENDENT
NADH-AZOREDUCTASE 1
(Bacillus
anthracis) 		5 / 11 VAL A  96
SER A 208
LEU A  34
HIS A  26
GLU A 204
 None
 1.31A 1mmtA-3u7iA:
undetectable		 1mmtA-3u7iA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3u7i FMN-DEPENDENT
NADH-AZOREDUCTASE 1
(Bacillus
anthracis) 		3 / 3 ARG A 209
ASN A  38
THR A   4
 None
 0.89A 2q63A-3u7iA:
undetectable		 2q63A-3u7iA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 3u7i FMN-DEPENDENT
NADH-AZOREDUCTASE 1
(Bacillus
anthracis) 		3 / 3 ASN A  93
ALA A  92
LYS A   3
 None
 1.04A 3runA-3u7iA:
undetectable		 3runA-3u7iA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_A_ACTA403_0
(3C-LIKE PROTEINASE)		 3u7i FMN-DEPENDENT
NADH-AZOREDUCTASE 1
(Bacillus
anthracis) 		4 / 5 TYR A 179
SER A 163
LEU A 167
GLN A 145
 None
 1.20A 4yo9A-3u7iA:
undetectable
4yo9B-3u7iA:
0.0		 4yo9A-3u7iA:
23.21
4yo9B-3u7iA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3u7i FMN-DEPENDENT
NADH-AZOREDUCTASE 1
(Bacillus
anthracis) 		3 / 3 GLU A 161
HIS A 164
ASP A 154
 None
CL  A 222 (-4.8A)
None
 0.64A 5c0oG-3u7iA:
undetectable		 5c0oG-3u7iA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3u7i FMN-DEPENDENT
NADH-AZOREDUCTASE 1
(Bacillus
anthracis) 		5 / 12 ILE A  85
VAL A  78
ALA A  61
VAL A  58
GLY A  66
 None
 1.26A 5igiA-3u7iA:
undetectable		 5igiA-3u7iA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_D8ZA831_0
(GEPHYRIN)		 3u7i FMN-DEPENDENT
NADH-AZOREDUCTASE 1
(Bacillus
anthracis) 		5 / 11 ILE A 144
LEU A  46
PRO A 107
TYR A 113
MET A 114
 None
 1.50A 6fgdA-3u7iA:
1.4		 6fgdA-3u7iA:
19.09