SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u7j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 3u7j RIBOSE-5-PHOSPHATE
ISOMERASE A
(Burkholderia
thailandensis) 		5 / 9 TYR A  54
ALA A  30
GLY A  29
GLY A  56
ILE A  32
 None
 1.28A 2v7bA-3u7jA:
2.5		 2v7bA-3u7jA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 3u7j RIBOSE-5-PHOSPHATE
ISOMERASE A
(Burkholderia
thailandensis) 		5 / 9 TYR A  54
ALA A  30
GLY A  29
GLY A  56
ILE A  32
 None
 1.28A 2v7bB-3u7jA:
2.3		 2v7bB-3u7jA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3u7j RIBOSE-5-PHOSPHATE
ISOMERASE A
(Burkholderia
thailandensis) 		5 / 12 PHE A 121
PHE A 211
ALA A 107
SER A  61
TYR A  87
 None
None
K  A 238 (-4.2A)
None
None
 1.43A 3apvA-3u7jA:
undetectable		 3apvA-3u7jA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3u7j RIBOSE-5-PHOSPHATE
ISOMERASE A
(Burkholderia
thailandensis) 		3 / 3 SER A  61
GLY A  35
GLY A  37
 None
None
SO4  A 236 ( 3.7A)
 0.49A 3bogA-3u7jA:
undetectable
3bogC-3u7jA:
undetectable		 3bogA-3u7jA:
undetectable
3bogC-3u7jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 3u7j RIBOSE-5-PHOSPHATE
ISOMERASE A
(Burkholderia
thailandensis) 		5 / 11 ILE A 124
ILE A  32
PHE A  43
ALA A  40
THR A  64
 None
 0.97A 3kw4A-3u7jA:
undetectable		 3kw4A-3u7jA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 3u7j RIBOSE-5-PHOSPHATE
ISOMERASE A
(Burkholderia
thailandensis) 		3 / 3 MET A   5
GLU A   9
LEU A  13
 None
EDO  A 239 (-4.0A)
None
 0.68A 4v2oB-3u7jA:
undetectable		 4v2oB-3u7jA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3u7j RIBOSE-5-PHOSPHATE
ISOMERASE A
(Burkholderia
thailandensis) 		5 / 12 GLY A 209
GLY A 103
GLY A 104
ALA A 212
LEU A 134
 None
K  A 238 ( 3.6A)
K  A 238 ( 4.8A)
None
None
 0.83A 5c0oF-3u7jA:
3.2		 5c0oF-3u7jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3u7j RIBOSE-5-PHOSPHATE
ISOMERASE A
(Burkholderia
thailandensis) 		5 / 9 VAL A  22
LEU A  47
ALA A  46
VAL A  34
ILE A  32
 None
 1.11A 5om2A-3u7jA:
undetectable
5om2B-3u7jA:
undetectable		 5om2A-3u7jA:
13.50
5om2B-3u7jA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		 3u7j RIBOSE-5-PHOSPHATE
ISOMERASE A
(Burkholderia
thailandensis) 		5 / 9 TYR A 173
ASP A 183
GLY A 104
GLY A 105
ALA A 107
 None
None
K  A 238 ( 4.8A)
K  A 238 (-3.9A)
K  A 238 (-4.2A)
 1.46A 5v3cA-3u7jA:
2.3		 5v3cA-3u7jA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 3u7j RIBOSE-5-PHOSPHATE
ISOMERASE A
(Burkholderia
thailandensis) 		4 / 8 GLY A 209
ARG A 165
ASP A 183
ASP A  92
 None
None
None
EDO  A 237 (-3.4A)
 1.01A 5vlmB-3u7jA:
undetectable		 5vlmB-3u7jA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 3u7j RIBOSE-5-PHOSPHATE
ISOMERASE A
(Burkholderia
thailandensis) 		4 / 8 ILE A 181
ARG A 165
VAL A 184
ASP A  92
 None
None
None
EDO  A 237 (-3.4A)
 1.05A 5vlmF-3u7jA:
undetectable		 5vlmF-3u7jA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 3u7j RIBOSE-5-PHOSPHATE
ISOMERASE A
(Burkholderia
thailandensis) 		4 / 7 SER A  70
ALA A  48
ILE A  32
ALA A  57
 None
 0.97A 6ma7A-3u7jA:
undetectable		 6ma7A-3u7jA:
15.88