SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u7u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		4 / 8 PHE A  51
LEU A  24
LEU A  72
LEU A  74
 None
 0.89A 2bfpA-3u7uA:
undetectable		 2bfpA-3u7uA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		4 / 8 PHE A  51
LEU A  24
LEU A  72
LEU A  74
 None
 0.89A 2bfpB-3u7uA:
undetectable		 2bfpB-3u7uA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
NEUREGULIN 1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 ASP A 125
TYR A 123
ALA A  93
ARG G  33
 None
 1.24A 2e5dA-3u7uA:
undetectable
2e5dB-3u7uA:
undetectable		 2e5dA-3u7uA:
23.05
2e5dB-3u7uA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 3u7u NEUREGULIN 1
RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		3 / 3 ARG A  99
GLU A  18
SER G   3
 None
 0.84A 2xkkA-3u7uA:
undetectable
2xkkC-3u7uA:
undetectable		 2xkkA-3u7uA:
21.43
2xkkC-3u7uA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 12 ARG A 401
THR A 455
GLN A 458
ILE A 428
SER A 408
 None
 1.37A 2xpvA-3u7uA:
undetectable		 2xpvA-3u7uA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		4 / 8 THR A 151
ARG A 171
ILE A 141
SER A 148
 None
 1.02A 2xytE-3u7uA:
undetectable		 2xytE-3u7uA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		4 / 8 THR A 151
ARG A 171
ILE A 141
SER A 148
 None
 1.06A 2xytH-3u7uA:
undetectable		 2xytH-3u7uA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 9 ILE A 417
ILE A 411
PHE A 422
ILE A 348
VAL A 402
 None
 1.37A 2ygpA-3u7uA:
undetectable		 2ygpA-3u7uA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		4 / 8 GLY A 311
GLY A 339
GLY A 375
ILE A 398
 None
 0.65A 3d41A-3u7uA:
undetectable		 3d41A-3u7uA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 11 LEU A 111
ILE A  40
VAL A  62
LEU A  38
VAL A  34
 None
 1.06A 3w67A-3u7uA:
undetectable		 3w67A-3u7uA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 11 LEU A 111
ILE A  43
ILE A  40
VAL A  62
LEU A  38
 None
 1.10A 3w67A-3u7uA:
undetectable		 3w67A-3u7uA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 12 ILE A 398
PHE A 422
ILE A 433
ILE A 435
LEU A 441
 None
 1.09A 3w67B-3u7uA:
undetectable		 3w67B-3u7uA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 12 LEU A 111
ILE A  43
ILE A  40
VAL A  62
LEU A  38
 None
 1.11A 3w67B-3u7uA:
undetectable		 3w67B-3u7uA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 12 LEU A 111
ILE A  40
VAL A  62
LEU A  38
VAL A  34
 None
 1.03A 3w68A-3u7uA:
undetectable		 3w68A-3u7uA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 12 LEU A 111
ILE A  40
VAL A  62
LEU A  38
VAL A  34
 None
 1.01A 3w68D-3u7uA:
undetectable		 3w68D-3u7uA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		4 / 6 GLY A  82
ASN A 119
LEU A  85
GLU A   8
 None
 0.95A 3zqtA-3u7uA:
undetectable		 3zqtA-3u7uA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		4 / 7 ASN A 338
ALA A 308
VAL A 370
ARG A 371
 None
 1.10A 4ijiH-3u7uA:
undetectable		 4ijiH-3u7uA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		4 / 8 VAL A 122
TRP A 138
ILE A 141
LEU A 111
 None
 0.94A 4jq1B-3u7uA:
undetectable		 4jq1B-3u7uA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 10 VAL A 122
TRP A 138
ILE A 141
LEU A  72
LEU A 111
 None
 1.42A 4jtqA-3u7uA:
undetectable		 4jtqA-3u7uA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 3u7u NEUREGULIN 1
RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		3 / 3 GLY G  44
GLU A   8
THR A   7
 None
 0.59A 4kouA-3u7uG:
undetectable		 4kouA-3u7uG:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 12 VAL A 323
ILE A 398
GLY A 339
GLY A 375
ILE A 312
 None
 1.04A 4mwzB-3u7uA:
undetectable		 4mwzB-3u7uA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 12 GLY A 399
ILE A 337
ASN A 338
SER A 408
ASN A 340
 None
 1.27A 4obwC-3u7uA:
undetectable		 4obwC-3u7uA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		4 / 7 ARG A  81
GLY A  60
THR A  83
VAL A  34
 None
 1.00A 4qwpB-3u7uA:
undetectable		 4qwpB-3u7uA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		3 / 3 PHE A  69
THR A   7
LEU A  52
 None
 0.61A 4qztA-3u7uA:
undetectable		 4qztA-3u7uA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		4 / 4 ILE A 379
ASN A 378
ILE A 312
VAL A 323
 None
 0.90A 4uy87-3u7uA:
undetectable		 4uy87-3u7uA:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		4 / 7 VAL A 122
TRP A 138
ILE A 141
LEU A  72
 None
 0.93A 4xo7B-3u7uA:
undetectable		 4xo7B-3u7uA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3u7u NEUREGULIN 1
RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 12 LEU A 344
ASP G  45
GLY G  44
ASN A 378
PHE A 376
 None
 1.33A 5kc4A-3u7uA:
undetectable		 5kc4A-3u7uA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		4 / 5 ILE A 379
PHE A 389
ASN A 470
TYR A 444
 None
 1.25A 6a93B-3u7uA:
undetectable		 6a93B-3u7uA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		3 / 3 LEU A 395
SER A 393
PHE A 392
 None
 0.65A 6fgcA-3u7uA:
undetectable		 6fgcA-3u7uA:
20.26