SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u7v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		5 / 12 GLY A 472
MET A 407
LEU A 411
LEU A 333
TYR A 329
 None
 1.48A 1fm6D-3u7vA:
undetectable		 1fm6D-3u7vA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		5 / 12 ALA A  60
ALA A  84
ALA A  59
MET A  57
LEU A  48
 None
 1.30A 1rbpA-3u7vA:
undetectable		 1rbpA-3u7vA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		4 / 8 ARG A 490
ASN A 534
GLN A 528
ASP A 530
 None
 1.35A 1zzuA-3u7vA:
undetectable		 1zzuA-3u7vA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_2
(NEURAMINIDASE)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		4 / 5 LEU A 112
ARG A 121
ARG A 116
ILE A 196
 None
 1.17A 2cmlA-3u7vA:
undetectable		 2cmlA-3u7vA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_2
(NEURAMINIDASE)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		4 / 5 LEU A 112
ARG A 121
ARG A 116
ILE A 196
 None
 1.14A 2cmlB-3u7vA:
undetectable		 2cmlB-3u7vA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_2
(NEURAMINIDASE)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		4 / 5 LEU A 112
ARG A 121
ARG A 116
ILE A 196
 None
 1.15A 2cmlC-3u7vA:
undetectable		 2cmlC-3u7vA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_2
(NEURAMINIDASE)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		4 / 5 LEU A 112
ARG A 121
ARG A 116
ILE A 196
 None
 1.13A 2cmlD-3u7vA:
undetectable		 2cmlD-3u7vA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		4 / 4 SER A 295
TRP A 130
ASP A 315
ILE A 314
 None
 1.49A 2oxtD-3u7vA:
0.2		 2oxtD-3u7vA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		5 / 9 TYR A 445
VAL A 489
GLY A 470
ARG A 356
GLY A 486
 None
 1.43A 3csjB-3u7vA:
undetectable		 3csjB-3u7vA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		3 / 3 ASP A 315
LEU A 316
GLN A 365
 None
 0.77A 3g4lA-3u7vA:
undetectable		 3g4lA-3u7vA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		5 / 12 GLY A 297
GLY A 298
ALA A 281
PRO A 165
TYR A 161
 None
 1.09A 3jayA-3u7vA:
undetectable		 3jayA-3u7vA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		5 / 12 GLN A  38
GLY A  52
PHE A  55
LEU A  48
ALA A  35
 None
 0.88A 3kkzA-3u7vA:
undetectable		 3kkzA-3u7vA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		5 / 12 GLN A  38
GLY A  52
PHE A  55
LEU A  48
ALA A  35
 None
 0.87A 3kkzB-3u7vA:
undetectable		 3kkzB-3u7vA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		5 / 8 TYR A 445
VAL A 489
GLY A 470
ARG A 356
GLY A 486
 None
 1.43A 3n9jB-3u7vA:
undetectable		 3n9jB-3u7vA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		5 / 12 GLY A 305
GLY A 234
ALA A 232
THR A 228
ALA A 227
 None
 1.08A 3sugA-3u7vA:
undetectable		 3sugA-3u7vA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		4 / 5 LEU A 112
ARG A 121
ARG A 116
ILE A 196
 None
 1.19A 3ticA-3u7vA:
undetectable		 3ticA-3u7vA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_2
(NEURAMINIDASE)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		4 / 5 LEU A 112
ARG A 121
ARG A 116
ILE A 196
 None
 1.19A 3ticD-3u7vA:
undetectable		 3ticD-3u7vA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		4 / 8 ASN A 381
ASP A 390
ASN A 350
ASP A 351
 None
 1.02A 4k0bA-3u7vA:
undetectable		 4k0bA-3u7vA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		4 / 8 ASN A 381
ASP A 390
ASN A 350
ASP A 351
 None
 1.02A 4l7iA-3u7vA:
undetectable		 4l7iA-3u7vA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		4 / 7 PHE A 252
ASP A 212
SER A 164
ALA A 216
 None
 1.25A 4lv9A-3u7vA:
3.3
4lv9B-3u7vA:
3.2		 4lv9A-3u7vA:
21.64
4lv9B-3u7vA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		3 / 3 ASP A 109
LEU A 108
PHE A 105
 None
 0.47A 4pthA-3u7vA:
undetectable		 4pthA-3u7vA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		5 / 12 ALA A 387
GLY A 385
ALA A  78
MET A 374
TYR A 376
 None
 1.28A 4r29A-3u7vA:
undetectable		 4r29A-3u7vA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		5 / 12 ALA A 387
GLY A 385
ALA A  78
MET A 374
TYR A 376
 None
 1.28A 4r29B-3u7vA:
undetectable		 4r29B-3u7vA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		4 / 7 GLN A 218
PRO A 215
ILE A 153
ASP A 212
 None
 1.09A 4w5oA-3u7vA:
2.9		 4w5oA-3u7vA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		4 / 7 GLN A 218
PRO A 215
ILE A 153
ASP A 212
 None
 1.09A 4z4eA-3u7vA:
2.8		 4z4eA-3u7vA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		4 / 7 GLN A 218
PRO A 215
ILE A 153
ASP A 212
 None
 1.07A 4z4gA-3u7vA:
2.7		 4z4gA-3u7vA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		4 / 5 GLN A 218
PRO A 215
ILE A 153
ASP A 212
 None
 1.08A 4z4hA-3u7vA:
2.7		 4z4hA-3u7vA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		4 / 7 THR A 204
PRO A 299
THR A 300
SER A 295
 None
 0.94A 5b6iA-3u7vA:
undetectable		 5b6iA-3u7vA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		5 / 12 GLY A 472
GLY A 422
GLY A 363
LEU A 362
LEU A 403
 None
 0.92A 5c0oF-3u7vA:
undetectable		 5c0oF-3u7vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		3 / 3 LYS A 147
ASP A 145
ARG A 151
 None
 1.09A 5jwaA-3u7vA:
undetectable
5jwaH-3u7vA:
undetectable		 5jwaA-3u7vA:
20.03
5jwaH-3u7vA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		5 / 12 VAL A 441
VAL A 544
LEU A 542
VAL A 489
LEU A 533
 None
 1.03A 6ajiA-3u7vA:
undetectable		 6ajiA-3u7vA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		5 / 12 PHE A 260
TYR A 272
ALA A 187
LEU A 124
MET A 276
 None
None
ACY  A 550 (-4.6A)
None
None
 1.34A 6aycA-3u7vA:
undetectable		 6aycA-3u7vA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		4 / 6 VAL A 123
LEU A 333
ARG A 338
PRO A 319
 None
 1.33A 6brdB-3u7vA:
undetectable		 6brdB-3u7vA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		5 / 11 VAL A 474
LEU A 473
ALA A 355
VAL A 489
TYR A 445
 None
 1.30A 6dryA-3u7vA:
undetectable		 6dryA-3u7vA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		5 / 10 VAL A 474
LEU A 483
LEU A 546
GLY A 486
VAL A 441
 None
 1.20A 6eu9B-3u7vA:
undetectable		 6eu9B-3u7vA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 3u7v BETA-GALACTOSIDASE
(Caulobacter
vibrioides) 		3 / 3 LEU A 108
SER A 106
PHE A 105
 None
 0.64A 6fgcA-3u7vA:
undetectable		 6fgcA-3u7vA:
22.28