SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u88'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 3u88 HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
LENS
EPITHELIUM-DERIVED
GROWTH FACTOR
(Homo
sapiens) 		5 / 9 PHE M 133
LEU C 383
ALA C 376
GLU C 395
LEU C 400
 None
 1.14A 2v0mB-3u88M:
undetectable		 2v0mB-3u88M:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 3u88 LENS
EPITHELIUM-DERIVED
GROWTH FACTOR
(Homo
sapiens) 		5 / 12 LEU C 383
LEU C 380
LEU C 377
ALA C 376
ALA C 357
 None
 1.07A 4fn9A-3u88C:
undetectable		 4fn9A-3u88C:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 3u88 LENS
EPITHELIUM-DERIVED
GROWTH FACTOR
(Homo
sapiens) 		5 / 12 LEU C 400
LEU C 377
SER C 409
LEU C 363
ILE C 359
 None
 1.00A 4x1fA-3u88C:
undetectable		 4x1fA-3u88C:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 3u88 LENS
EPITHELIUM-DERIVED
GROWTH FACTOR
(Homo
sapiens) 		5 / 12 LEU C 400
LEU C 377
SER C 409
LEU C 363
ILE C 359
 None
 1.01A 4x1gA-3u88C:
undetectable		 4x1gA-3u88C:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 3u88 LENS
EPITHELIUM-DERIVED
GROWTH FACTOR
(Homo
sapiens) 		5 / 12 MET C 418
ALA C 381
LEU C 400
ILE C 397
VAL C 385
 None
 1.32A 5vlmB-3u88C:
undetectable		 5vlmB-3u88C:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 3u88 LENS
EPITHELIUM-DERIVED
GROWTH FACTOR
(Homo
sapiens) 		5 / 12 MET C 418
ALA C 381
LEU C 400
ILE C 397
VAL C 385
 None
 1.35A 5vlmE-3u88C:
undetectable		 5vlmE-3u88C:
16.76