SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u8e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3u8e PAPAIN-LIKE CYSTEINE
PROTEASE
(Crocus
sativus) 		5 / 11 ILE A 166
LEU A 165
HIS A 162
GLY A 214
SER A 215
 None
SO4  A 227 ( 4.3A)
None
None
None
 1.36A 1kyvA-3u8eA:
undetectable
1kyvB-3u8eA:
undetectable		 1kyvA-3u8eA:
20.35
1kyvB-3u8eA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3u8e PAPAIN-LIKE CYSTEINE
PROTEASE
(Crocus
sativus) 		3 / 3 VAL A  54
ASP A  55
GLU A  50
 None
NA  A 224 (-2.9A)
None
 0.72A 2qeuA-3u8eA:
undetectable		 2qeuA-3u8eA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3u8e PAPAIN-LIKE CYSTEINE
PROTEASE
(Crocus
sativus) 		3 / 3 VAL A  54
ASP A  55
GLU A  50
 None
NA  A 224 (-2.9A)
None
 0.71A 2qeuC-3u8eA:
undetectable		 2qeuC-3u8eA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 3u8e PAPAIN-LIKE CYSTEINE
PROTEASE
(Crocus
sativus) 		3 / 3 TRP A  26
GLN A  19
TRP A 213
 None
 1.12A 2vqyA-3u8eA:
undetectable		 2vqyA-3u8eA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3u8e PAPAIN-LIKE CYSTEINE
PROTEASE
(Crocus
sativus) 		4 / 5 TYR A  89
SER A 184
ASP A  84
ILE A  81
 GOL  A 226 ( 4.4A)
SO4  A 227 ( 4.7A)
GOL  A 226 ( 4.0A)
None
 1.36A 3uj7B-3u8eA:
undetectable		 3uj7B-3u8eA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3u8e PAPAIN-LIKE CYSTEINE
PROTEASE
(Crocus
sativus) 		5 / 12 THR A  90
GLN A  51
LYS A 100
ASP A  97
GLY A  94
 NA  A 224 ( 4.1A)
NA  A 224 (-4.4A)
None
None
NA  A 224 ( 4.3A)
 1.31A 5m66D-3u8eA:
undetectable		 5m66D-3u8eA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3u8e PAPAIN-LIKE CYSTEINE
PROTEASE
(Crocus
sativus) 		4 / 6 SER A 136
TYR A 133
GLN A 140
THR A 159
 None
 1.37A 6djzA-3u8eA:
undetectable		 6djzA-3u8eA:
19.84