SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u8p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Escherichia
coli) 		4 / 5 ASP A 115
LEU A 118
LYS A 119
ARG A  76
 None
 1.27A 2gj5A-3u8pA:
undetectable		 2gj5A-3u8pA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Escherichia
coli) 		5 / 10 ALA A  78
ALA A  77
ALA A  82
VAL A  58
ILE A  59
 None
 1.13A 3falA-3u8pA:
undetectable		 3falA-3u8pA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN
(Escherichia
coli;
Aequorea
victoria) 		4 / 6 ILE A 296
PHE A 191
ALA A 195
ASN A 293
 None
 1.14A 3pgyA-3u8pA:
2.1
3pgyB-3u8pA:
undetectable		 3pgyA-3u8pA:
23.20
3pgyB-3u8pA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Escherichia
coli) 		5 / 9 PHE A 179
VAL A 220
ASN A 229
ILE A  14
PHE A   8
 None
CRO  A 175 ( 4.8A)
CRO  A 175 ( 3.5A)
None
None
 1.19A 3t3rB-3u8pA:
undetectable		 3t3rB-3u8pA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Escherichia
coli) 		5 / 9 PHE A 179
VAL A 220
ASN A 229
ILE A  14
PHE A   8
 None
CRO  A 175 ( 4.8A)
CRO  A 175 ( 3.5A)
None
None
 1.23A 3t3rC-3u8pA:
undetectable		 3t3rC-3u8pA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Escherichia
coli) 		5 / 10 PHE A 179
VAL A 220
ASN A 229
ILE A  14
PHE A   8
 None
CRO  A 175 ( 4.8A)
CRO  A 175 ( 3.5A)
None
None
 1.19A 3t3rD-3u8pA:
undetectable		 3t3rD-3u8pA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN
(Escherichia
coli;
Aequorea
victoria) 		4 / 7 ASP A  19
THR A 216
SER A  28
PHE A  27
 None
 1.05A 4ac9C-3u8pA:
undetectable		 4ac9C-3u8pA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN
(Escherichia
coli;
Aequorea
victoria) 		3 / 3 VAL A  22
GLY A  24
LYS A  26
 None
 0.78A 4k50A-3u8pA:
1.9		 4k50A-3u8pA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN
(Escherichia
coli;
Aequorea
victoria) 		3 / 3 VAL A  22
GLY A  24
LYS A  26
 None
 0.77A 4k50I-3u8pA:
undetectable		 4k50I-3u8pA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Escherichia
coli) 		4 / 6 LYS A 146
ASP A  36
TYR A 147
PRO A  87
 None
None
None
HEM  A 347 ( 4.9A)
 1.04A 5bmvB-3u8pA:
undetectable		 5bmvB-3u8pA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Escherichia
coli) 		4 / 7 ILE A 206
ASP A 237
GLY A 212
PHE A 208
 None
 0.93A 5h3aA-3u8pA:
undetectable		 5h3aA-3u8pA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Escherichia
coli) 		4 / 8 TYR A 200
PHE A 192
VAL A 271
ILE A 231
 None
 0.94A 5hw8H-3u8pA:
undetectable		 5hw8H-3u8pA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Escherichia
coli) 		3 / 3 VAL A  16
LYS A 221
MET A 196
 None
 1.04A 5nknA-3u8pA:
undetectable		 5nknA-3u8pA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN
(Escherichia
coli;
Aequorea
victoria) 		5 / 10 SER A 194
LEU A 309
SER A 180
ILE A 260
PRO A 304
 None
 1.45A 6dlzB-3u8pA:
3.7
6dlzC-3u8pA:
5.5		 6dlzB-3u8pA:
13.66
6dlzC-3u8pA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN
(Escherichia
coli;
Aequorea
victoria) 		5 / 11 ILE A 260
PRO A 304
SER A 194
LEU A 309
SER A 180
 None
 1.45A 6dlzA-3u8pA:
6.0
6dlzD-3u8pA:
3.7		 6dlzA-3u8pA:
13.66
6dlzD-3u8pA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN
(Escherichia
coli;
Aequorea
victoria) 		5 / 10 SER A 194
LEU A 309
SER A 180
ILE A 260
PRO A 304
 None
 1.44A 6dm1B-3u8pA:
3.7
6dm1C-3u8pA:
5.9		 6dm1B-3u8pA:
13.66
6dm1C-3u8pA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN
(Escherichia
coli;
Aequorea
victoria) 		5 / 11 ILE A 260
PRO A 304
SER A 194
LEU A 309
SER A 180
 None
 1.44A 6dm1A-3u8pA:
6.0
6dm1D-3u8pA:
3.7		 6dm1A-3u8pA:
13.66
6dm1D-3u8pA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN
(Escherichia
coli;
Aequorea
victoria) 		5 / 10 SER A 194
LEU A 309
SER A 180
ILE A 260
PRO A 304
 None
 1.44A 6dm2B-3u8pA:
3.7
6dm2C-3u8pA:
5.7		 6dm2B-3u8pA:
13.66
6dm2C-3u8pA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN
(Escherichia
coli;
Aequorea
victoria) 		5 / 10 ILE A 260
PRO A 304
SER A 194
LEU A 309
SER A 180
 None
 1.44A 6dm2A-3u8pA:
6.2
6dm2D-3u8pA:
5.0		 6dm2A-3u8pA:
13.66
6dm2D-3u8pA:
13.66