SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u9j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens) 		4 / 8 GLU A 131
SER A  81
GLU A 130
GLU A 129
 None
None
FE  A 200 ( 2.5A)
None
 1.18A 1knyA-3u9jA:
5.2
1knyB-3u9jA:
4.8		 1knyA-3u9jA:
21.71
1knyB-3u9jA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens) 		3 / 3 GLU A 130
HIS A 126
HIS A  80
 FE  A 200 ( 2.5A)
FE  A 200 (-3.5A)
FE  A 200 (-3.4A)
 0.61A 1oe2A-3u9jA:
undetectable		 1oe2A-3u9jA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_1
(ORPHAN NUCLEAR
RECEPTOR PXR)		 3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens) 		5 / 12 LEU A 138
MET A 137
SER A  73
ILE A 150
PHE A 142
 None
 1.48A 1skxA-3u9jA:
undetectable		 1skxA-3u9jA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens) 		4 / 5 LEU A  44
LEU A  47
LEU A  89
LEU A  91
 None
 0.82A 2ab2B-3u9jA:
undetectable		 2ab2B-3u9jA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens) 		3 / 3 HIS A  57
MET A  18
MET A 127
 FE  A 201 (-3.4A)
None
None
 1.41A 2vj1A-3u9jA:
undetectable		 2vj1A-3u9jA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens) 		5 / 11 HIS A 126
GLU A 130
HIS A  80
GLU A  58
PHE A 119
 FE  A 200 (-3.5A)
FE  A 200 ( 2.5A)
FE  A 200 (-3.4A)
FE  A 200 (-2.6A)
None
 1.17A 2x8zA-3u9jA:
undetectable		 2x8zA-3u9jA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens) 		5 / 11 HIS A  57
HIS A  15
HIS A 126
HIS A  80
VAL A  79
 FE  A 201 (-3.4A)
FE  A 201 (-3.3A)
FE  A 200 (-3.5A)
FE  A 200 (-3.4A)
None
 1.42A 2zweA-3u9jA:
undetectable
2zweB-3u9jA:
undetectable		 2zweA-3u9jA:
17.07
2zweB-3u9jA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens) 		5 / 11 HIS A  57
HIS A  15
HIS A 126
HIS A  80
VAL A  79
 FE  A 201 (-3.4A)
FE  A 201 (-3.3A)
FE  A 200 (-3.5A)
FE  A 200 (-3.4A)
None
 1.46A 2zwfA-3u9jA:
undetectable
2zwfB-3u9jA:
undetectable		 2zwfA-3u9jA:
17.07
2zwfB-3u9jA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens) 		5 / 11 HIS A  57
HIS A  15
HIS A 126
HIS A  80
VAL A  79
 FE  A 201 (-3.4A)
FE  A 201 (-3.3A)
FE  A 200 (-3.5A)
FE  A 200 (-3.4A)
None
 1.47A 2zwgA-3u9jA:
undetectable
2zwgB-3u9jA:
undetectable		 2zwgA-3u9jA:
17.07
2zwgB-3u9jA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BL1_A_BL1A300_1
(CARBONIC ANHYDRASE 2)		 3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens) 		5 / 12 ASN A  83
HIS A 126
HIS A  57
HIS A  15
VAL A 154
 None
FE  A 200 (-3.5A)
FE  A 201 (-3.4A)
FE  A 201 (-3.3A)
None
 0.83A 3bl1A-3u9jA:
undetectable		 3bl1A-3u9jA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens) 		3 / 3 HIS A 126
GLU A 129
ASN A  78
 FE  A 200 (-3.5A)
None
None
 1.03A 4bupB-3u9jA:
undetectable		 4bupB-3u9jA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens) 		5 / 11 HIS A 126
GLU A 130
HIS A  80
GLU A  58
PHE A 119
 FE  A 200 (-3.5A)
FE  A 200 ( 2.5A)
FE  A 200 (-3.4A)
FE  A 200 (-2.6A)
None
 1.20A 4c2pA-3u9jA:
4.3		 4c2pA-3u9jA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens) 		4 / 7 HIS A  80
HIS A 126
HIS A  15
HIS A  57
 FE  A 200 (-3.4A)
FE  A 200 (-3.5A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
 0.75A 4p6sA-3u9jA:
undetectable		 4p6sA-3u9jA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens) 		4 / 7 HIS A  80
HIS A 126
HIS A  15
HIS A  57
 FE  A 200 (-3.4A)
FE  A 200 (-3.5A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
 0.75A 4p6sB-3u9jA:
undetectable		 4p6sB-3u9jA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens) 		5 / 12 PHE A 142
ILE A  66
SER A  73
VAL A 133
HIS A 126
 None
None
None
None
FE  A 200 (-3.5A)
 1.28A 5h1eA-3u9jA:
undetectable		 5h1eA-3u9jA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens) 		5 / 12 PHE A 142
LEU A 138
ILE A  66
SER A  73
VAL A 133
 None
 1.45A 5h1eA-3u9jA:
undetectable		 5h1eA-3u9jA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens) 		4 / 7 HIS A  80
HIS A 126
HIS A  15
HIS A  57
 FE  A 200 (-3.4A)
FE  A 200 (-3.5A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
 0.77A 5i3aA-3u9jA:
undetectable		 5i3aA-3u9jA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens) 		4 / 7 HIS A  80
HIS A 126
HIS A  15
HIS A  57
 FE  A 200 (-3.4A)
FE  A 200 (-3.5A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
 0.76A 5i3aB-3u9jA:
undetectable		 5i3aB-3u9jA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens) 		4 / 7 HIS A  80
HIS A 126
HIS A  15
HIS A  57
 FE  A 200 (-3.4A)
FE  A 200 (-3.5A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
 0.78A 5i3bA-3u9jA:
undetectable		 5i3bA-3u9jA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens) 		4 / 5 LEU A  44
TYR A  48
LEU A  96
GLU A  93
 None
 1.30A 5weaA-3u9jA:
undetectable		 5weaA-3u9jA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens) 		5 / 11 HIS A  57
HIS A  15
HIS A 126
HIS A  80
VAL A  79
 FE  A 201 (-3.4A)
FE  A 201 (-3.3A)
FE  A 200 (-3.5A)
FE  A 200 (-3.4A)
None
 1.50A 5z0hA-3u9jA:
undetectable
5z0hB-3u9jA:
undetectable		 5z0hA-3u9jA:
18.12
5z0hB-3u9jA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens) 		5 / 11 HIS A  57
HIS A  15
HIS A 126
HIS A  80
VAL A  79
 FE  A 201 (-3.4A)
FE  A 201 (-3.3A)
FE  A 200 (-3.5A)
FE  A 200 (-3.4A)
None
 1.44A 5z0jA-3u9jA:
undetectable
5z0jB-3u9jA:
undetectable		 5z0jA-3u9jA:
18.12
5z0jB-3u9jA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens) 		5 / 11 HIS A  57
HIS A  15
HIS A 126
HIS A  80
VAL A  79
 FE  A 201 (-3.4A)
FE  A 201 (-3.3A)
FE  A 200 (-3.5A)
FE  A 200 (-3.4A)
None
 1.45A 5z0kA-3u9jA:
undetectable
5z0kB-3u9jA:
undetectable		 5z0kA-3u9jA:
18.12
5z0kB-3u9jA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens) 		5 / 11 HIS A  57
HIS A  15
HIS A 126
HIS A  80
VAL A  79
 FE  A 201 (-3.4A)
FE  A 201 (-3.3A)
FE  A 200 (-3.5A)
FE  A 200 (-3.4A)
None
 1.50A 5z0lA-3u9jA:
undetectable
5z0lB-3u9jA:
undetectable		 5z0lA-3u9jA:
18.12
5z0lB-3u9jA:
16.56