SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u9r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT
(Pseudomonas
aeruginosa) 		5 / 10 ALA B 371
VAL B 334
ILE B 441
VAL B 339
ILE B 335
 None
 0.96A 1hsgA-3u9rB:
undetectable		 1hsgA-3u9rB:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT
(Pseudomonas
aeruginosa) 		4 / 7 PHE B 437
ALA B 548
ILE B 553
PRO B 435
 None
 0.73A 1oniA-3u9rB:
undetectable
1oniB-3u9rB:
undetectable		 1oniA-3u9rB:
13.65
1oniB-3u9rB:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT
(Pseudomonas
aeruginosa) 		4 / 7 ILE B 553
PRO B 435
PHE B 437
ALA B 548
 None
 0.63A 1oniG-3u9rB:
undetectable
1oniI-3u9rB:
undetectable		 1oniG-3u9rB:
13.65
1oniI-3u9rB:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT
(Pseudomonas
aeruginosa) 		5 / 12 GLU B 333
VAL B 339
GLU B 346
ALA B 371
LEU B 399
 None
 1.12A 1sn5B-3u9rB:
undetectable
1sn5D-3u9rB:
undetectable		 1sn5B-3u9rB:
13.86
1sn5D-3u9rB:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT
(Pseudomonas
aeruginosa) 		5 / 12 GLU B 346
ALA B 371
LEU B 399
GLU B 333
VAL B 339
 None
 1.15A 1sn5B-3u9rB:
undetectable
1sn5D-3u9rB:
undetectable		 1sn5B-3u9rB:
13.86
1sn5D-3u9rB:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT
(Pseudomonas
aeruginosa) 		5 / 11 ASP B 137
GLY B  66
ARG B  84
HIS B  64
VAL B 120
 None
 1.41A 1tmxA-3u9rB:
undetectable		 1tmxA-3u9rB:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT
(Pseudomonas
aeruginosa) 		5 / 12 GLY B 118
ASP B 137
ARG B  84
ALA B 116
ALA B 102
 None
 1.06A 2bm9F-3u9rB:
undetectable		 2bm9F-3u9rB:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT
(Pseudomonas
aeruginosa) 		5 / 12 LEU B 545
LEU B 302
TYR B 365
ASP B 340
ALA B 360
 None
 1.12A 2br4D-3u9rB:
undetectable		 2br4D-3u9rB:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT
(Pseudomonas
aeruginosa) 		4 / 6 LEU B  90
ILE B 209
VAL B 211
ALA B 287
 None
 0.95A 2j5mA-3u9rB:
undetectable		 2j5mA-3u9rB:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT
(Pseudomonas
aeruginosa) 		4 / 7 ILE B  87
LEU B  90
VAL B 126
GLY B 124
 None
 0.81A 2wd9A-3u9rB:
undetectable		 2wd9A-3u9rB:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT
(Pseudomonas
aeruginosa) 		4 / 6 ALA B 116
LEU B 103
SER B 523
VAL B 120
 None
 1.06A 3d2tB-3u9rB:
undetectable		 3d2tB-3u9rB:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT
(Pseudomonas
aeruginosa) 		5 / 10 ALA B 371
VAL B 334
ILE B 441
VAL B 339
ILE B 335
 None
 0.99A 3em3B-3u9rB:
undetectable		 3em3B-3u9rB:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT
(Pseudomonas
aeruginosa) 		5 / 12 HIS B  75
LEU B  82
GLY B  67
GLY B  68
ALA B 138
 None
 1.22A 3i5uA-3u9rB:
undetectable		 3i5uA-3u9rB:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT
(Pseudomonas
aeruginosa) 		5 / 10 ALA B 371
VAL B 334
ILE B 441
VAL B 339
ILE B 335
 None
 0.97A 3nu6A-3u9rB:
undetectable		 3nu6A-3u9rB:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT
(Pseudomonas
aeruginosa) 		5 / 11 ALA B 371
VAL B 334
ILE B 441
VAL B 339
ILE B 335
 None
 1.05A 3oxvD-3u9rB:
undetectable		 3oxvD-3u9rB:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT
(Pseudomonas
aeruginosa) 		5 / 12 ILE B 119
ALA B 116
ALA B 117
ALA B 102
ILE B 194
 None
 1.16A 3uvvB-3u9rB:
undetectable		 3uvvB-3u9rB:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT
(Pseudomonas
aeruginosa) 		4 / 5 LEU B 362
LEU B 399
THR B 537
TRP B 465
 None
 1.34A 4do3A-3u9rB:
undetectable		 4do3A-3u9rB:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT
(Pseudomonas
aeruginosa) 		4 / 7 VAL B 334
ILE B 335
LEU B 545
LEU B 362
 None
 1.02A 4l1wA-3u9rB:
undetectable		 4l1wA-3u9rB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT
(Pseudomonas
aeruginosa) 		4 / 5 ILE B  87
LEU B  91
GLU B  99
VAL B 540
 None
 0.95A 4nkxB-3u9rB:
undetectable		 4nkxB-3u9rB:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT
(Pseudomonas
aeruginosa) 		5 / 12 ILE B 119
ALA B 116
ALA B 117
ALA B 102
ILE B 194
 None
 1.03A 4nqaH-3u9rB:
undetectable		 4nqaH-3u9rB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT
(Pseudomonas
aeruginosa) 		4 / 4 ALA B  40
ALA B  43
ALA B  44
ALA B  47
 None
 0.10A 4oadA-3u9rB:
2.0		 4oadA-3u9rB:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT
(Pseudomonas
aeruginosa) 		4 / 4 ALA B  40
ALA B  43
ALA B  44
ALA B  47
 None
 0.10A 4oaeA-3u9rB:
undetectable		 4oaeA-3u9rB:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT
(Pseudomonas
aeruginosa) 		5 / 12 ALA B 428
GLN B 402
ILE B 404
ASN B 372
LEU B 376
 None
 1.10A 4r3aA-3u9rB:
undetectable		 4r3aA-3u9rB:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT
(Pseudomonas
aeruginosa) 		5 / 10 ARG B 332
LEU B 399
ILE B 367
GLY B 358
LEU B 338
 None
 1.05A 5o96C-3u9rB:
undetectable
5o96D-3u9rB:
undetectable		 5o96C-3u9rB:
17.64
5o96D-3u9rB:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT
(Pseudomonas
aeruginosa) 		4 / 7 ARG B 525
ARG B 180
PRO B 147
TYR B 146
 None
 0.97A 5x80C-3u9rB:
undetectable
5x80D-3u9rB:
undetectable		 5x80C-3u9rB:
19.27
5x80D-3u9rB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT
(Pseudomonas
aeruginosa) 		4 / 6 LEU B  90
VAL B 140
MET B 132
GLY B 124
 None
 0.94A 6hd4B-3u9rB:
undetectable		 6hd4B-3u9rB:
9.96