SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3u9w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 12 ILE A1476
ALA A1478
LEU A1483
ILE A1517
LEU A1541
 None
 0.95A 1drfA-3u9wA:
undetectable		 1drfA-3u9wA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 12 HIS A1295
GLU A1296
HIS A1299
GLU A1318
TYR A1383
 ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.6A)
 0.70A 1j36A-3u9wA:
4.2		 1j36A-3u9wA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 12 HIS A1295
GLU A1296
HIS A1299
GLU A1318
TYR A1383
 ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.6A)
 0.70A 1j36B-3u9wA:
4.3		 1j36B-3u9wA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 11 HIS A1295
GLU A1296
HIS A1299
GLU A1318
TYR A1383
 ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.6A)
 0.70A 1j37A-3u9wA:
3.6		 1j37A-3u9wA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 11 HIS A1295
GLU A1296
HIS A1299
GLU A1318
TYR A1383
 ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.6A)
 0.70A 1j37B-3u9wA:
4.3		 1j37B-3u9wA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGL_L_ESTL911_1
(IG GAMMA-1-CHAIN
IG KAPPA-CHAIN)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 10 GLN A1395
GLY A1386
ALA A1342
TYR A1460
HIS A1339
 None
 1.44A 1jglH-3u9wA:
undetectable
1jglL-3u9wA:
undetectable		 1jglH-3u9wA:
16.64
1jglL-3u9wA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 12 HIS A1295
GLU A1296
HIS A1299
GLU A1318
TYR A1383
 ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.6A)
 0.64A 1o86A-3u9wA:
4.7		 1o86A-3u9wA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 12 GLY A1344
GLY A1345
GLY A1347
PHE A1340
ASN A1500
 IMD  A2009 (-4.1A)
None
IMD  A2009 (-3.5A)
None
IMD  A2010 (-3.7A)
 0.86A 1qzzA-3u9wA:
undetectable		 1qzzA-3u9wA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 8 GLU A1318
HIS A1295
HIS A1299
GLU A1296
 ZN  A2001 ( 2.2A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
 0.89A 1v7zA-3u9wA:
undetectable		 1v7zA-3u9wA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 8 GLU A1318
HIS A1295
HIS A1299
GLU A1296
 ZN  A2001 ( 2.2A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
 0.89A 1v7zB-3u9wA:
undetectable		 1v7zB-3u9wA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 8 GLU A1318
HIS A1295
HIS A1299
GLU A1296
 ZN  A2001 ( 2.2A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
 0.89A 1v7zC-3u9wA:
undetectable		 1v7zC-3u9wA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 12 GLY A1344
GLY A1345
GLY A1347
PHE A1340
ASN A1500
 IMD  A2009 (-4.1A)
None
IMD  A2009 (-3.5A)
None
IMD  A2010 (-3.7A)
 0.79A 1xdsA-3u9wA:
undetectable		 1xdsA-3u9wA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 12 GLY A1344
GLY A1345
GLY A1347
PHE A1340
ASN A1500
 IMD  A2009 (-4.1A)
None
IMD  A2009 (-3.5A)
None
IMD  A2010 (-3.7A)
 0.81A 1xdsB-3u9wA:
undetectable		 1xdsB-3u9wA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 12 HIS A1295
GLU A1296
HIS A1299
GLU A1318
TYR A1383
 ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.6A)
 0.63A 2c6nA-3u9wA:
3.2		 2c6nA-3u9wA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 12 HIS A1295
GLU A1296
HIS A1299
GLU A1318
TYR A1383
 ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.6A)
 0.67A 2c6nB-3u9wA:
4.7		 2c6nB-3u9wA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 12 LEU A1512
LEU A1503
LEU A1541
LEU A1539
ILE A1529
 None
 0.88A 2ouzA-3u9wA:
undetectable		 2ouzA-3u9wA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 12 LEU A1404
LEU A1407
ILE A1328
ALA A1244
GLU A1318
 None
None
None
None
ZN  A2001 ( 2.2A)
 1.28A 2v0mC-3u9wA:
undetectable		 2v0mC-3u9wA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 11 HIS A1295
GLU A1296
HIS A1299
GLU A1318
TYR A1383
 ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.6A)
 0.61A 2x8zA-3u9wA:
5.3		 2x8zA-3u9wA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 12 HIS A1295
GLU A1296
HIS A1299
GLU A1318
TYR A1383
 ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.6A)
 0.61A 2x91A-3u9wA:
3.3		 2x91A-3u9wA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 7 SER A1051
GLN A1147
ILE A1102
SER A1011
 None
 1.02A 2xz5A-3u9wA:
3.5
2xz5B-3u9wA:
3.5		 2xz5A-3u9wA:
17.32
2xz5B-3u9wA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 8 SER A1051
GLN A1147
ILE A1102
SER A1011
 None
 1.02A 2xz5B-3u9wA:
3.5
2xz5E-3u9wA:
3.3		 2xz5B-3u9wA:
17.32
2xz5E-3u9wA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 8 GLU A1318
HIS A1295
HIS A1299
GLU A1296
 ZN  A2001 ( 2.2A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
 0.88A 3a6jA-3u9wA:
undetectable		 3a6jA-3u9wA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 7 GLU A1318
HIS A1295
HIS A1299
GLU A1296
 ZN  A2001 ( 2.2A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
 0.85A 3a6jB-3u9wA:
undetectable		 3a6jB-3u9wA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 8 GLU A1318
HIS A1295
HIS A1299
GLU A1296
 ZN  A2001 ( 2.2A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
 0.86A 3a6jC-3u9wA:
undetectable		 3a6jC-3u9wA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 8 GLU A1318
HIS A1295
HIS A1299
GLU A1296
 ZN  A2001 ( 2.2A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
 0.89A 3a6jE-3u9wA:
undetectable		 3a6jE-3u9wA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 8 GLU A1318
HIS A1295
HIS A1299
GLU A1296
 ZN  A2001 ( 2.2A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
 0.85A 3a6jF-3u9wA:
undetectable		 3a6jF-3u9wA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 9 LEU A1021
LEU A1144
ILE A1088
ILE A1066
VAL A1042
 None
 1.22A 3tmzA-3u9wA:
undetectable		 3tmzA-3u9wA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 12 TYR A1156
SER A1133
LEU A1034
PHE A1106
CYH A1025
 None
 1.46A 3u9fD-3u9wA:
undetectable
3u9fE-3u9wA:
undetectable		 3u9fD-3u9wA:
14.48
3u9fE-3u9wA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 12 TYR A1156
SER A1133
LEU A1034
PHE A1106
CYH A1025
 None
 1.37A 3u9fH-3u9wA:
undetectable
3u9fI-3u9wA:
undetectable		 3u9fH-3u9wA:
14.48
3u9fI-3u9wA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 12 ILE A1476
LEU A1503
LEU A1512
ALA A1510
ILE A1469
 None
 1.01A 3vrmA-3u9wA:
undetectable		 3vrmA-3u9wA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 5 ILE A1476
GLN A1473
ILE A1469
GLU A1501
 None
None
None
IMD  A2009 (-2.7A)
 0.98A 4a99D-3u9wA:
undetectable		 4a99D-3u9wA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 11 HIS A1295
GLU A1296
HIS A1299
GLU A1318
TYR A1383
 ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.6A)
 0.72A 4c2pA-3u9wA:
4.4		 4c2pA-3u9wA:
24.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		9 / 9 TYR A1267
GLY A1268
HIS A1295
GLU A1296
GLU A1318
TYR A1378
TYR A1383
ARG A1563
LYS A1565
 28P  A7001 (-3.6A)
None
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.3A)
28P  A7001 (-4.6A)
None
None
 0.36A 4dprA-3u9wA:
61.2		 4dprA-3u9wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 9 TYR A1267
GLY A1269
GLU A1271
TYR A1378
TYR A1383
 28P  A7001 (-3.6A)
None
28P  A7001 (-3.6A)
28P  A7001 (-4.3A)
28P  A7001 (-4.6A)
 0.99A 4dprA-3u9wA:
61.2		 4dprA-3u9wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		6 / 9 TYR A1267
GLY A1269
HIS A1295
GLU A1318
TYR A1378
TYR A1383
 28P  A7001 (-3.6A)
None
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.3A)
28P  A7001 (-4.6A)
 0.89A 4dprA-3u9wA:
61.2		 4dprA-3u9wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 9 TYR A1267
GLY A1269
HIS A1299
GLU A1271
TYR A1378
 28P  A7001 (-3.6A)
None
ZN  A2001 ( 3.2A)
28P  A7001 (-3.6A)
28P  A7001 (-4.3A)
 1.08A 4dprA-3u9wA:
61.2		 4dprA-3u9wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 9 TYR A1267
GLY A1269
HIS A1299
GLU A1318
TYR A1378
 28P  A7001 (-3.6A)
None
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.3A)
 1.18A 4dprA-3u9wA:
61.2		 4dprA-3u9wA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 5 THR A1302
THR A1421
LEU A1389
LEU A1390
 None
 0.99A 4lvcB-3u9wA:
undetectable		 4lvcB-3u9wA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 7 LYS A1565
ASN A1291
GLU A1533
ARG A1563
 None
 1.37A 4mv7A-3u9wA:
undetectable		 4mv7A-3u9wA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 6 LEU A1390
HIS A1299
HIS A1295
GLU A1318
 None
ZN  A2001 ( 3.2A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
 0.95A 4pahA-3u9wA:
undetectable		 4pahA-3u9wA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 8 THR A1279
ARG A1563
VAL A1292
SER A1290
 None
 1.08A 4qknA-3u9wA:
undetectable		 4qknA-3u9wA:
22.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		12 / 12 GLN A1136
ALA A1137
TYR A1267
HIS A1295
GLU A1296
HIS A1299
TRP A1311
PHE A1314
GLU A1318
LEU A1369
TYR A1378
TYR A1383
 28P  A7001 (-3.7A)
28P  A7001 ( 3.8A)
28P  A7001 (-3.6A)
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
28P  A7001 (-4.8A)
28P  A7001 (-3.5A)
ZN  A2001 ( 2.2A)
28P  A7001 ( 4.9A)
28P  A7001 (-4.3A)
28P  A7001 (-4.6A)
 0.35A 4r7lA-3u9wA:
64.7		 4r7lA-3u9wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 12 TYR A1267
GLU A1271
GLU A1318
TYR A1378
TYR A1383
 28P  A7001 (-3.6A)
28P  A7001 (-3.6A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.3A)
28P  A7001 (-4.6A)
 1.33A 4r7lA-3u9wA:
64.7		 4r7lA-3u9wA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_B_Y70B151_1
(CEREBLON ISOFORM 4)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 8 ASN A1272
MET A1270
TRP A1253
TYR A1251
 None
28P  A7001 (-3.5A)
None
None
 1.47A 4v2zB-3u9wA:
undetectable		 4v2zB-3u9wA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 8 ASN A1272
MET A1270
TRP A1253
TYR A1251
 None
28P  A7001 (-3.5A)
None
None
 1.46A 4v30B-3u9wA:
undetectable		 4v30B-3u9wA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 7 GLU A1296
ARG A1338
ILE A1328
MET A1240
 28P  A7001 (-2.6A)
None
None
None
 0.98A 4xumA-3u9wA:
undetectable		 4xumA-3u9wA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 5 SER A1290
ARG A1338
GLY A1334
GLU A1335
 None
 1.06A 5cdqA-3u9wA:
1.8
5cdqB-3u9wA:
undetectable
5cdqC-3u9wA:
2.0		 5cdqA-3u9wA:
22.27
5cdqB-3u9wA:
16.02
5cdqC-3u9wA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 5 SER A1290
ARG A1338
GLY A1334
GLU A1335
 None
 1.08A 5cdqR-3u9wA:
1.4
5cdqS-3u9wA:
undetectable
5cdqT-3u9wA:
undetectable		 5cdqR-3u9wA:
22.27
5cdqS-3u9wA:
16.02
5cdqT-3u9wA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 10 ALA A1038
LEU A1040
LEU A1054
VAL A1064
ILE A1088
 None
 0.99A 5v02B-3u9wA:
2.5
5v02R-3u9wA:
undetectable		 5v02B-3u9wA:
9.76
5v02R-3u9wA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 10 LEU A1040
VAL A1101
LEU A1054
VAL A1064
ILE A1088
 None
 1.09A 5v02B-3u9wA:
2.5
5v02R-3u9wA:
undetectable		 5v02B-3u9wA:
9.76
5v02R-3u9wA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 9 ASP A1578
LEU A1555
ALA A1584
VAL A1585
ASP A1582
 None
 1.17A 6c2mB-3u9wA:
undetectable		 6c2mB-3u9wA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		3 / 3 LEU A1115
ASN A1272
LEU A1261
 None
 0.73A 6exiD-3u9wA:
undetectable		 6exiD-3u9wA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 6 LEU A1390
HIS A1299
HIS A1295
GLU A1318
 None
ZN  A2001 ( 3.2A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
 0.96A 6pahA-3u9wA:
undetectable		 6pahA-3u9wA:
19.02