SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uaf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3uaf TTR-52
(Caenorhabditis
elegans) 		3 / 3 GLN A  73
ILE A 108
HIS A  95
 None
 0.69A 1fm9A-3uafA:
undetectable		 1fm9A-3uafA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3uaf TTR-52
(Caenorhabditis
elegans) 		3 / 3 GLN A  73
ILE A 108
HIS A  95
 None
 0.68A 1k74A-3uafA:
undetectable		 1k74A-3uafA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 3uaf TTR-52
(Caenorhabditis
elegans) 		4 / 5 ALA A  53
TRP A  48
LEU A  60
ALA A  52
 None
 0.89A 2jstA-3uafA:
undetectable
2jstB-3uafA:
undetectable		 2jstA-3uafA:
19.44
2jstB-3uafA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 3uaf TTR-52
(Caenorhabditis
elegans) 		5 / 12 ASP A  67
LEU A  47
ILE A  93
ASN A  71
LEU A 123
 None
 1.12A 4fr0A-3uafA:
undetectable		 4fr0A-3uafA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3uaf TTR-52
(Caenorhabditis
elegans) 		3 / 3 GLN A  73
ILE A 108
HIS A  95
 None
 0.63A 5z12B-3uafA:
undetectable		 5z12B-3uafA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3uaf TTR-52
(Caenorhabditis
elegans) 		4 / 7 ILE A 110
LEU A  91
ARG A 130
LEU A  31
 None
 0.98A 6nmfA-3uafA:
undetectable
6nmfJ-3uafA:
undetectable		 6nmfA-3uafA:
12.58
6nmfJ-3uafA:
16.24