SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uai'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 4
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 143
VAL A 127
GLY A 184
LEU A 199
 None
 0.78A 1jlbA-3uaiA:
1.9		 1jlbA-3uaiA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 4
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 143
VAL A 127
GLY A 184
LEU A 199
 None
 0.88A 1s1xA-3uaiA:
2.0		 1s1xA-3uaiA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 1
(Saccharomyces
cerevisiae) 		3 / 3 CYH C  53
PRO C  46
ASP C 107
 None
 0.90A 3hlwB-3uaiC:
undetectable		 3hlwB-3uaiC:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)		 3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 4 PHE C 109
LYS C 108
ILE C  51
THR C  73
 None
 1.46A 3ia4B-3uaiC:
undetectable		 3ia4B-3uaiC:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 7 GLY C 106
CYH C  94
PHE C 109
GLY C  41
 None
 0.84A 3ko0M-3uaiC:
undetectable
3ko0P-3uaiC:
undetectable		 3ko0M-3uaiC:
18.42
3ko0P-3uaiC:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 7 PHE C 109
GLY C  41
GLY C 106
CYH C  94
 None
 0.78A 3ko0M-3uaiC:
undetectable
3ko0P-3uaiC:
undetectable		 3ko0M-3uaiC:
18.42
3ko0P-3uaiC:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 4
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 104
ALA A 109
LEU A 252
ILE A  62
THR A 110
 None
 1.03A 3qfxA-3uaiA:
undetectable		 3qfxA-3uaiA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 1
(Saccharomyces
cerevisiae) 		3 / 3 TYR C  62
LEU C  69
LYS C  72
 None
 0.79A 3sueD-3uaiC:
4.2		 3sueD-3uaiC:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 1
H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 4
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 138
ASP A 135
GLU C 105
GLU C  87
 None
 1.07A 4feuD-3uaiA:
undetectable		 4feuD-3uaiA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 1
(Saccharomyces
cerevisiae) 		3 / 3 ARG C  54
LEU C  44
GLU C 105
 None
 0.77A 4l3gF-3uaiC:
undetectable		 4l3gF-3uaiC:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_1
(ANDROGEN RECEPTOR)		 3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 1
H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 4
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 150
GLY C  83
LEU A 206
MET A 205
VAL A 201
 None
 1.19A 4ojbA-3uaiA:
undetectable		 4ojbA-3uaiA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 1
H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 4
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 150
GLY C  83
LEU A 206
MET A 205
VAL A 201
 None
 1.19A 4okxA-3uaiA:
undetectable		 4okxA-3uaiA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 1
(Saccharomyces
cerevisiae) 		3 / 3 CYH C  53
PRO C  46
ASP C 107
 None
 0.98A 4pm5A-3uaiC:
undetectable		 4pm5A-3uaiC:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 4
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 162
MET A 205
VAL A 201
THR A 198
 None
 0.96A 5e4dA-3uaiA:
undetectable
5e4dB-3uaiA:
undetectable		 5e4dA-3uaiA:
20.65
5e4dB-3uaiA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 4
H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 THR C  91
MET A 205
VAL A 201
THR A 198
 None
 1.01A 5e4dA-3uaiC:
undetectable
5e4dB-3uaiC:
undetectable		 5e4dA-3uaiC:
20.40
5e4dB-3uaiC:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 4
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 336
LEU A  25
ALA A 314
ARG A 111
LEU A 112
 None
 1.42A 5nd2B-3uaiA:
undetectable		 5nd2B-3uaiA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 4
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 184
LEU A 139
GLN A 214
VAL A 127
LEU A 203
 None
 1.25A 5ubbA-3uaiA:
undetectable		 5ubbA-3uaiA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 4
(Saccharomyces
cerevisiae) 		5 / 9 ASP A 273
ALA A 312
ILE A 313
GLY A  45
GLY A 310
 None
 1.24A 6awoA-3uaiA:
undetectable		 6awoA-3uaiA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 4
(Saccharomyces
cerevisiae) 		5 / 9 ASP A 273
ALA A 312
ILE A 313
GLY A  45
GLY A 310
 None
 1.25A 6awqA-3uaiA:
undetectable		 6awqA-3uaiA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 4
H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 THR A 147
LEU A 146
MET A 196
LEU C  85
 None
 1.21A 6mvxA-3uaiA:
undetectable
6mvxB-3uaiA:
undetectable
6mvxC-3uaiA:
undetectable		 6mvxA-3uaiA:
22.87
6mvxB-3uaiA:
22.87
6mvxC-3uaiA:
22.87