SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ubd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 3ubd RIBOSOMAL PROTEIN S6
KINASE ALPHA-3
(Mus
musculus) 		3 / 3 PHE A 259
LEU A 285
MET A 279
 None
 0.77A 1mx1D-3ubdA:
undetectable		 1mx1D-3ubdA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 3ubd RIBOSOMAL PROTEIN S6
KINASE ALPHA-3
(Mus
musculus) 		4 / 5 LEU A 201
GLY A 205
HIS A 206
ILE A 207
 None
 0.84A 1xf1A-3ubdA:
undetectable		 1xf1A-3ubdA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 3ubd RIBOSOMAL PROTEIN S6
KINASE ALPHA-3
(Mus
musculus) 		4 / 6 LEU A 201
GLY A 205
HIS A 206
ILE A 207
 None
 0.89A 1xf1B-3ubdA:
undetectable		 1xf1B-3ubdA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 3ubd RIBOSOMAL PROTEIN S6
KINASE ALPHA-3
(Mus
musculus) 		6 / 12 GLY A 152
GLY A 153
VAL A 131
LEU A 200
LEU A  74
LEU A 147
 None
None
SL0  A 400 (-3.9A)
SL0  A 400 (-4.7A)
None
SL0  A 400 (-3.7A)
 1.49A 1ya4C-3ubdA:
undetectable		 1ya4C-3ubdA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 3ubd RIBOSOMAL PROTEIN S6
KINASE ALPHA-3
(Mus
musculus) 		5 / 12 ASP A 250
PHE A 228
HIS A  55
SER A 215
ASP A 193
 None
 1.37A 2pgfA-3ubdA:
undetectable		 2pgfA-3ubdA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ubd RIBOSOMAL PROTEIN S6
KINASE ALPHA-3
(Mus
musculus) 		4 / 5 GLN A 138
PHE A 137
LEU A 133
PHE A 212
 None
None
None
SL0  A 400 ( 4.5A)
 1.29A 3ablC-3ubdA:
undetectable
3ablJ-3ubdA:
undetectable		 3ablC-3ubdA:
22.60
3ablJ-3ubdA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3ubd RIBOSOMAL PROTEIN S6
KINASE ALPHA-3
(Mus
musculus) 		4 / 4 LEU A 200
MET A 261
ILE A 189
ASP A 193
 SL0  A 400 (-4.7A)
None
None
None
 1.16A 3hecA-3ubdA:
4.2		 3hecA-3ubdA:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3ubd RIBOSOMAL PROTEIN S6
KINASE ALPHA-3
(Mus
musculus) 		5 / 12 GLY A 205
ILE A 207
ASP A 154
ARG A 158
LEU A 201
 None
 1.25A 3iv6D-3ubdA:
undetectable		 3iv6D-3ubdA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 3ubd RIBOSOMAL PROTEIN S6
KINASE ALPHA-3
(Mus
musculus) 		3 / 3 LEU A 145
ARG A 110
ASN A 198
 SL0  A 400 ( 4.8A)
None
None
 0.75A 3qxvD-3ubdA:
undetectable		 3qxvD-3ubdA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 3ubd RIBOSOMAL PROTEIN S6
KINASE ALPHA-3
(Mus
musculus) 		4 / 5 ASP A 182
GLU A 319
GLY A 317
GLN A 247
 None
 1.38A 3w9tE-3ubdA:
undetectable		 3w9tE-3ubdA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 3ubd RIBOSOMAL PROTEIN S6
KINASE ALPHA-3
(Mus
musculus) 		4 / 5 ASP A 182
GLU A 319
GLY A 317
GLN A 247
 None
 1.33A 3w9tG-3ubdA:
undetectable		 3w9tG-3ubdA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ubd RIBOSOMAL PROTEIN S6
KINASE ALPHA-3
(Mus
musculus) 		3 / 3 LEU A 266
PRO A 267
ARG A 273
 None
 0.56A 4klrB-3ubdA:
undetectable		 4klrB-3ubdA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3ubd RIBOSOMAL PROTEIN S6
KINASE ALPHA-3
(Mus
musculus) 		5 / 12 PRO A 196
LEU A 257
VAL A 170
TYR A 173
LEU A 177
 None
 1.49A 5cymA-3ubdA:
undetectable		 5cymA-3ubdA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 3ubd RIBOSOMAL PROTEIN S6
KINASE ALPHA-3
(Mus
musculus) 		3 / 3 THR A  53
ASP A 193
GLU A 197
 None
 0.76A 5fa8A-3ubdA:
undetectable		 5fa8A-3ubdA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 3ubd RIBOSOMAL PROTEIN S6
KINASE ALPHA-3
(Mus
musculus) 		4 / 5 ILE A 199
LEU A 302
GLY A 255
PHE A 254
 None
 0.85A 5kmdC-3ubdA:
undetectable
5kmdD-3ubdA:
1.4		 5kmdC-3ubdA:
22.92
5kmdD-3ubdA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 3ubd RIBOSOMAL PROTEIN S6
KINASE ALPHA-3
(Mus
musculus) 		4 / 6 ASP A 250
GLY A 314
PRO A 315
GLY A 317
 None
 0.55A 6ag0C-3ubdA:
undetectable		 6ag0C-3ubdA:
14.19