SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ubh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 3ubh NEURAL-CADHERIN
(Drosophila
melanogaster) 		5 / 11 GLY A 704
SER A 672
ILE A 671
LEU A 742
VAL A 727
 None
 0.94A 2kawA-3ubhA:
undetectable		 2kawA-3ubhA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 3ubh NEURAL-CADHERIN
(Drosophila
melanogaster) 		6 / 12 PHE A 826
VAL A 846
ALA A 763
VAL A 828
ILE A 770
THR A 848
 None
 1.43A 3czhA-3ubhA:
undetectable		 3czhA-3ubhA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 3ubh NEURAL-CADHERIN
(Drosophila
melanogaster) 		6 / 12 PHE A 826
VAL A 846
ALA A 763
VAL A 828
ILE A 770
THR A 848
 None
 1.42A 3dl9A-3ubhA:
undetectable		 3dl9A-3ubhA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 3ubh NEURAL-CADHERIN
(Drosophila
melanogaster) 		4 / 8 SER A 786
ASP A 751
ASP A 783
ASP A 832
 None
CA  A 855 ( 2.5A)
CA  A 857 (-2.2A)
CA  A 857 (-3.5A)
 1.23A 3n2oC-3ubhA:
undetectable
3n2oD-3ubhA:
undetectable		 3n2oC-3ubhA:
19.97
3n2oD-3ubhA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3ubh NEURAL-CADHERIN
(Drosophila
melanogaster) 		4 / 5 SER A 737
THR A 728
GLU A 731
ASP A 680
 None
 1.29A 3tm4A-3ubhA:
undetectable		 3tm4A-3ubhA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3ubh NEURAL-CADHERIN
(Drosophila
melanogaster) 		4 / 5 SER A 737
THR A 728
GLU A 731
ASP A 680
 None
 1.26A 3tm4B-3ubhA:
undetectable		 3tm4B-3ubhA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3ubh NEURAL-CADHERIN
(Drosophila
melanogaster) 		5 / 12 GLY A 625
ASP A 622
ILE A 578
ASN A 577
TYR A 542
 None
CA  A 854 (-3.3A)
None
None
None
 1.13A 4rtsA-3ubhA:
undetectable		 4rtsA-3ubhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 3ubh NEURAL-CADHERIN
(Drosophila
melanogaster) 		3 / 3 VAL A 722
THR A 743
ARG A 745
 None
 0.71A 5b2sB-3ubhA:
undetectable		 5b2sB-3ubhA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 3ubh NEURAL-CADHERIN
(Drosophila
melanogaster) 		3 / 3 VAL A 722
THR A 743
ARG A 745
 None
 0.74A 5b2tB-3ubhA:
undetectable		 5b2tB-3ubhA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 3ubh NEURAL-CADHERIN
(Drosophila
melanogaster) 		3 / 3 LYS A 676
GLN A 568
ASN A 545
 None
 0.95A 5l2tA-3ubhA:
undetectable		 5l2tA-3ubhA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWV_A_BEZA202_0
(ARA H 8 ALLERGEN)		 3ubh NEURAL-CADHERIN
(Drosophila
melanogaster) 		4 / 4 PHE A 801
ASP A 799
LEU A 815
LYS A 813
 None
 1.29A 6awvA-3ubhA:
undetectable		 6awvA-3ubhA:
18.23