SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ubl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 3ubl GLUTATHIONE
TRANSFERASE
(Leptospira
interrogans) 		3 / 3 ALA A 158
HIS A 159
VAL A 162
 None
 0.30A 1lqtB-3ublA:
undetectable		 1lqtB-3ublA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 3ubl GLUTATHIONE
TRANSFERASE
(Leptospira
interrogans) 		3 / 3 ALA A 158
HIS A 159
VAL A 162
 None
 0.30A 1lquB-3ublA:
undetectable		 1lquB-3ublA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 3ubl GLUTATHIONE
TRANSFERASE
(Leptospira
interrogans) 		4 / 4 HIS A 159
ALA A 158
PHE A 157
GLY A 156
 None
 1.23A 1mj2B-3ublA:
undetectable		 1mj2B-3ublA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 3ubl GLUTATHIONE
TRANSFERASE
(Leptospira
interrogans) 		4 / 4 HIS A 159
ALA A 158
PHE A 157
GLY A 156
 None
 1.24A 1mj2D-3ublA:
undetectable		 1mj2D-3ublA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 3ubl GLUTATHIONE
TRANSFERASE
(Leptospira
interrogans) 		4 / 4 HIS A 159
ALA A 158
PHE A 157
GLY A 156
 None
 1.22A 1mjoB-3ublA:
undetectable		 1mjoB-3ublA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 3ubl GLUTATHIONE
TRANSFERASE
(Leptospira
interrogans) 		4 / 4 HIS A 159
ALA A 158
PHE A 157
GLY A 156
 None
 1.22A 1mjoA-3ublA:
undetectable		 1mjoA-3ublA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 3ubl GLUTATHIONE
TRANSFERASE
(Leptospira
interrogans) 		4 / 4 HIS A 159
ALA A 158
PHE A 157
GLY A 156
 None
 1.24A 1mjoD-3ublA:
undetectable		 1mjoD-3ublA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3ubl GLUTATHIONE
TRANSFERASE
(Leptospira
interrogans) 		3 / 3 THR A  76
ASP A 153
SER A 155
 SO4  A 243 (-3.8A)
None
None
 0.67A 2nxeA-3ublA:
undetectable		 2nxeA-3ublA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3ubl GLUTATHIONE
TRANSFERASE
(Leptospira
interrogans) 		3 / 3 THR A  76
ASP A 153
SER A 155
 SO4  A 243 (-3.8A)
None
None
 0.70A 2nxeB-3ublA:
undetectable		 2nxeB-3ublA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 3ubl GLUTATHIONE
TRANSFERASE
(Leptospira
interrogans) 		4 / 4 LEU A  18
GLY A  19
LEU A  21
GLU A  22
 None
None
None
SO4  A 242 ( 4.0A)
 1.10A 3tgvB-3ublA:
undetectable		 3tgvB-3ublA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3ubl GLUTATHIONE
TRANSFERASE
(Leptospira
interrogans) 		4 / 5 LEU A 134
ASP A 153
GLU A  98
VAL A 162
 None
None
GSH  A 241 ( 4.9A)
None
 1.11A 4nkvA-3ublA:
undetectable		 4nkvA-3ublA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3ubl GLUTATHIONE
TRANSFERASE
(Leptospira
interrogans) 		5 / 12 LEU A 160
ILE A  97
GLY A 130
VAL A 138
VAL A 137
 None
 0.94A 4nkxC-3ublA:
undetectable		 4nkxC-3ublA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3ubl GLUTATHIONE
TRANSFERASE
(Leptospira
interrogans) 		5 / 12 LEU A 160
ILE A  97
GLY A 130
VAL A 138
VAL A 137
 None
 0.95A 4nkxD-3ublA:
undetectable		 4nkxD-3ublA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 3ubl GLUTATHIONE
TRANSFERASE
(Leptospira
interrogans) 		4 / 7 GLY A 156
PHE A 157
HIS A 159
VAL A 162
 None
 0.98A 6hu9S-3ublA:
undetectable
6hu9q-3ublA:
undetectable		 6hu9S-3ublA:
17.89
6hu9q-3ublA:
21.07