SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ubm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		4 / 6 ASN A  72
ALA A  33
GLY A  36
TYR A  35
 None
 1.12A 1c8lA-3ubmA:
2.1		 1c8lA-3ubmA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		5 / 8 LEU A 195
VAL A 199
VAL A  39
ASP A  18
VAL A  16
 None
 1.41A 1iwiA-3ubmA:
undetectable		 1iwiA-3ubmA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWJ_A_CAMA418_0
(CYTOCHROME P450-CAM)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		5 / 9 LEU A 195
VAL A 199
VAL A  39
ASP A  18
VAL A  16
 None
 1.40A 1iwjA-3ubmA:
undetectable		 1iwjA-3ubmA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		5 / 12 ILE A  50
ASP A  49
LEU A  55
GLY A  21
ASN A  70
 None
 1.17A 1likA-3ubmA:
3.5		 1likA-3ubmA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		5 / 10 LEU A 195
VAL A 199
VAL A  39
ASP A  18
VAL A  16
 None
 1.34A 1o76A-3ubmA:
undetectable		 1o76A-3ubmA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		4 / 6 LEU A 226
ALA A 222
LEU A 186
VAL A 217
 None
 0.93A 1sn5A-3ubmA:
undetectable		 1sn5A-3ubmA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		4 / 8 LEU A 226
ALA A 222
LEU A 186
VAL A 217
 None
 0.98A 1sn5C-3ubmA:
undetectable		 1sn5C-3ubmA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		5 / 9 LEU A 195
VAL A 199
VAL A  39
ASP A  18
VAL A  16
 None
 1.33A 1t86B-3ubmA:
undetectable		 1t86B-3ubmA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		4 / 7 ASP A  18
GLY A  20
GLY A  21
ASN A 102
 None
None
None
COA  A2001 (-4.0A)
 0.67A 2c49B-3ubmA:
2.6		 2c49B-3ubmA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		5 / 12 ILE A 331
LEU A 274
CYH A 289
VAL A 352
HIS A 346
 None
 1.18A 2qo5A-3ubmA:
undetectable		 2qo5A-3ubmA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		3 / 3 LEU A 118
TYR A 117
GLN A 120
 None
 0.64A 2wekA-3ubmA:
4.4		 2wekA-3ubmA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		4 / 5 ASN A  72
ALA A  33
GLY A  36
TYR A  35
 None
 1.15A 3bcrA-3ubmA:
4.1		 3bcrA-3ubmA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		5 / 9 LEU A 195
VAL A 199
VAL A  39
ASP A  18
VAL A  16
 None
 1.44A 3cppA-3ubmA:
0.0		 3cppA-3ubmA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		5 / 12 ILE A  98
ALA A  96
LEU A 118
GLN A 119
LYS A 214
 None
 1.17A 3ix9A-3ubmA:
undetectable		 3ix9A-3ubmA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		4 / 6 ASP A 412
LEU A 415
ASP A 430
THR A 434
 None
 0.86A 3rozA-3ubmA:
4.1		 3rozA-3ubmA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		5 / 12 GLY A  48
VAL A  22
GLY A 408
SER A  75
ALA A 404
 None
COA  A2001 ( 4.9A)
None
None
None
 1.10A 3sueC-3ubmA:
undetectable		 3sueC-3ubmA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		3 / 3 LYS A   9
PRO A  10
LEU A  11
 None
 0.75A 3tpxE-3ubmA:
undetectable		 3tpxE-3ubmA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		4 / 8 ASP A  62
ASN A  53
ARG A  56
GLY A 408
 None
 0.89A 4af0A-3ubmA:
undetectable		 4af0A-3ubmA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		5 / 12 TYR A 117
ILE A 433
LYS A 431
VAL A  88
ILE A  42
 None
 1.41A 4eb6B-3ubmA:
undetectable
4eb6C-3ubmA:
3.2		 4eb6B-3ubmA:
20.93
4eb6C-3ubmA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		5 / 9 LEU A 195
VAL A 199
VAL A  39
ASP A  18
VAL A  16
 None
 1.39A 4ek1B-3ubmA:
undetectable		 4ek1B-3ubmA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		4 / 6 LEU A 226
ALA A 222
LEU A 186
VAL A 217
 None
 1.14A 5a6iA-3ubmA:
undetectable		 5a6iA-3ubmA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		4 / 5 LEU A 226
ALA A 222
LEU A 186
VAL A 217
 None
 1.10A 5cr1A-3ubmA:
undetectable		 5cr1A-3ubmA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		3 / 3 ARG A 429
THR A 411
ASP A 412
 None
 0.78A 5g5gA-3ubmA:
undetectable
5g5gB-3ubmA:
undetectable		 5g5gA-3ubmA:
20.88
5g5gB-3ubmA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		5 / 12 ILE A  42
ILE A  17
VAL A  76
GLU A 413
ASP A  38
 None
 1.21A 5lg3J-3ubmA:
undetectable		 5lg3J-3ubmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		4 / 8 PRO A 259
ALA A 155
THR A 159
ALA A 264
 None
 0.98A 5x2tI-3ubmA:
undetectable
5x2tJ-3ubmA:
undetectable
5x2tK-3ubmA:
undetectable
5x2tL-3ubmA:
undetectable		 5x2tI-3ubmA:
14.32
5x2tJ-3ubmA:
18.44
5x2tK-3ubmA:
14.32
5x2tL-3ubmA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		4 / 7 PHE A 103
SER A  24
VAL A  22
ARG A  44
 COA  A2001 (-3.6A)
COA  A2001 (-3.2A)
COA  A2001 ( 4.9A)
COA  A2001 (-3.2A)
 1.26A 6av6C-3ubmA:
undetectable
6av6D-3ubmA:
undetectable		 6av6C-3ubmA:
8.47
6av6D-3ubmA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		5 / 12 GLY A  48
VAL A  22
GLY A 408
SER A  75
ALA A 404
 None
COA  A2001 ( 4.9A)
None
None
None
 1.08A 6c2mA-3ubmA:
undetectable		 6c2mA-3ubmA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		5 / 12 GLY A  48
VAL A  22
GLY A 408
SER A  75
ALA A 404
 None
COA  A2001 ( 4.9A)
None
None
None
 1.03A 6c2mB-3ubmA:
undetectable		 6c2mB-3ubmA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE
(Acetobacter
aceti) 		5 / 12 ARG A  74
VAL A  76
ILE A  42
VAL A  16
ILE A  17
 None
 1.49A 6gsdA-3ubmA:
5.7		 6gsdA-3ubmA:
10.99