SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ubw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SFU_C_RBVC601_1 (RNA POLYMERASE)	3ubw	14-3-3 PROTEIN EPSILON (Homo sapiens)	5 / 11	ARG A 57 LEU A 93 LEU A 101 GLY A 126 ASP A 127	None None CSO A 98 ( 4.7A) None None	1.28A	3sfuC-3ubwA: undetectable	3sfuC-3ubwA: 20.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5JM4_A_BEZA301_0 (14-3-3 PROTEIN ZETA/DELTA)	3ubw	14-3-3 PROTEIN EPSILON (Homo sapiens)	4 / 5	PHE A 199 ILE A 203 MET A 221 ARG A 225	None	1.03A	5jm4A-3ubwA: 32.4	5jm4A-3ubwA: 62.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5M35_A_BEZA302_0 (14-3-3 PROTEIN ZETA/DELTA)	3ubw	14-3-3 PROTEIN EPSILON (Homo sapiens)	4 / 5	PHE A 199 THR A 218 MET A 221 ARG A 225	None	1.21A	5m35A-3ubwA: 33.5	5m35A-3ubwA: 69.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TJY_A_BEZA304_0 (4-HYDROXY-TETRAHYDRO DIPICOLINATE REDUCTASE)	3ubw	14-3-3 PROTEIN EPSILON (Homo sapiens)	3 / 3	MET A 33 GLU A 5 ARG A 4	None	1.07A	5tjyA-3ubwA: undetectable	5tjyA-3ubwA: 22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6FI4_B_DVAB8_0 (14-3-3 PROTEIN SIGMA PRO-SEP-LEU-PRO-DVA)	3ubw	14-3-3 PROTEIN EPSILON (Homo sapiens)	4 / 5	SER A 46 VAL A 47 LYS A 50 ASN A 51	None None 6SP A 240 ( 4.8A) None	1.18A	6fi4A-3ubwA: 32.4 6fi4B-3ubwA: undetectable	6fi4A-3ubwA: 62.87 6fi4B-3ubwA: 1.94

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3SFU_C_RBVC601_1","RNA POLYMERASE","3ubw","14-3-3 PROTEIN EPSILON","Homo sapiens",5,"ARG A  57;LEU A  93;LEU A 101;GLY A 126;ASP A 127","None;None;CSO A  98 ( 4.7A);None;None","1.28A","3sfuC-3ubwA:undetectable","3sfuC-3ubwA:20.24"],["5JM4_A_BEZA301_0","14-3-3 PROTEIN ZETA\/DELTA","3ubw","14-3-3 PROTEIN EPSILON","Homo sapiens",4,"PHE A 199;ILE A 203;MET A 221;ARG A 225","None","1.03A","5jm4A-3ubwA:32.4","5jm4A-3ubwA:62.31"],["5M35_A_BEZA302_0","14-3-3 PROTEIN ZETA\/DELTA","3ubw","14-3-3 PROTEIN EPSILON","Homo sapiens",4,"PHE A 199;THR A 218;MET A 221;ARG A 225","None","1.21A","5m35A-3ubwA:33.5","5m35A-3ubwA:69.40"],["5TJY_A_BEZA304_0","4-HYDROXY-TETRAHYDRODIPICOLINATE REDUCTASE","3ubw","14-3-3 PROTEIN EPSILON","Homo sapiens",3,"MET A  33;GLU A   5;ARG A   4","None","1.07A","5tjyA-3ubwA:undetectable","5tjyA-3ubwA:22.92"],["6FI4_B_DVAB8_0","14-3-3 PROTEIN SIGMA;PRO-SEP-LEU-PRO-DVA","3ubw","14-3-3 PROTEIN EPSILON","Homo sapiens",4,"SER A  46;VAL A  47;LYS A  50;ASN A  51","None;None;6SP A 240 ( 4.8A);None","1.18A","6fi4A-3ubwA:32.4;6fi4B-3ubwA:undetectable","6fi4A-3ubwA:62.87;6fi4B-3ubwA:1.94"]]