SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uc3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 3uc3 SERINE/THREONINE-PRO
TEIN KINASE SRK2I
(Arabidopsis
thaliana) 		3 / 3 GLN A 304
TYR A  22
ARG A  37
 None
 0.96A 1gtbA-3uc3A:
undetectable		 1gtbA-3uc3A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 3uc3 SERINE/THREONINE-PRO
TEIN KINASE SRK2I
(Arabidopsis
thaliana) 		4 / 6 LEU A 103
TYR A 104
ARG A 106
LEU A 144
 None
 0.98A 3f33A-3uc3A:
2.8		 3f33A-3uc3A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3uc3 SERINE/THREONINE-PRO
TEIN KINASE SRK2I
(Arabidopsis
thaliana) 		3 / 3 TYR A 183
THR A 207
GLU A 219
 None
 0.82A 4df3A-3uc3A:
undetectable		 4df3A-3uc3A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3uc3 SERINE/THREONINE-PRO
TEIN KINASE SRK2I
(Arabidopsis
thaliana) 		3 / 3 TYR A 183
THR A 207
GLU A 219
 None
 0.83A 4df3B-3uc3A:
undetectable		 4df3B-3uc3A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 3uc3 SERINE/THREONINE-PRO
TEIN KINASE SRK2I
(Arabidopsis
thaliana) 		3 / 3 ARG A  80
ASP A  41
ASP A  18
 None
 0.85A 4kicB-3uc3A:
undetectable		 4kicB-3uc3A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 3uc3 SERINE/THREONINE-PRO
TEIN KINASE SRK2I
(Arabidopsis
thaliana) 		5 / 12 LEU A 208
ILE A 272
GLU A 115
LEU A 212
SER A 248
 None
 1.19A 4r88A-3uc3A:
undetectable		 4r88A-3uc3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 3uc3 SERINE/THREONINE-PRO
TEIN KINASE SRK2I
(Arabidopsis
thaliana) 		5 / 12 LEU A 208
ILE A 272
GLU A 115
LEU A 212
SER A 248
 None
 1.16A 4r88B-3uc3A:
undetectable		 4r88B-3uc3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 3uc3 SERINE/THREONINE-PRO
TEIN KINASE SRK2I
(Arabidopsis
thaliana) 		5 / 12 LEU A 208
ILE A 272
GLU A 115
LEU A 212
SER A 248
 None
 1.17A 4r88C-3uc3A:
undetectable		 4r88C-3uc3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 3uc3 SERINE/THREONINE-PRO
TEIN KINASE SRK2I
(Arabidopsis
thaliana) 		5 / 12 LEU A 208
ILE A 272
GLU A 115
LEU A 212
SER A 248
 None
 1.17A 4r88D-3uc3A:
undetectable		 4r88D-3uc3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 3uc3 SERINE/THREONINE-PRO
TEIN KINASE SRK2I
(Arabidopsis
thaliana) 		5 / 12 LEU A 208
ILE A 272
GLU A 115
LEU A 212
SER A 248
 None
 1.16A 4r88E-3uc3A:
undetectable		 4r88E-3uc3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 3uc3 SERINE/THREONINE-PRO
TEIN KINASE SRK2I
(Arabidopsis
thaliana) 		5 / 12 LEU A 208
ILE A 272
GLU A 115
LEU A 212
SER A 248
 None
 1.17A 4r88F-3uc3A:
undetectable		 4r88F-3uc3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 3uc3 SERINE/THREONINE-PRO
TEIN KINASE SRK2I
(Arabidopsis
thaliana) 		4 / 6 ILE A  78
PHE A 162
ARG A 140
ILE A 137
 None
None
None
CO  A 362 (-4.9A)
 1.27A 4zzcA-3uc3A:
2.9
4zzcB-3uc3A:
2.9		 4zzcA-3uc3A:
22.83
4zzcB-3uc3A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 3uc3 SERINE/THREONINE-PRO
TEIN KINASE SRK2I
(Arabidopsis
thaliana) 		4 / 6 ILE A  78
PHE A 162
ARG A 140
ILE A 137
 None
None
None
CO  A 362 (-4.9A)
 1.29A 4zzcB-3uc3A:
2.9
4zzcC-3uc3A:
2.9		 4zzcB-3uc3A:
22.83
4zzcC-3uc3A:
22.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3uc3 SERINE/THREONINE-PRO
TEIN KINASE SRK2I
(Arabidopsis
thaliana) 		6 / 12 ALA A  49
ILE A  93
TYR A  97
ALA A  98
CYH A 160
GLY A 163
 None
None
None
None
CO  A 363 (-2.0A)
None
 1.26A 5hesA-3uc3A:
8.7		 5hesA-3uc3A:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3uc3 SERINE/THREONINE-PRO
TEIN KINASE SRK2I
(Arabidopsis
thaliana) 		6 / 12 ALA A  49
ILE A  93
TYR A  97
ALA A  98
CYH A 160
GLY A 163
 None
None
None
None
CO  A 363 (-2.0A)
None
 1.38A 5hesB-3uc3A:
20.3		 5hesB-3uc3A:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3uc3 SERINE/THREONINE-PRO
TEIN KINASE SRK2I
(Arabidopsis
thaliana) 		6 / 11 GLY A  34
ALA A  49
VAL A  79
TYR A  97
ALA A  98
LEU A 148
 None
 0.63A 5lvnA-3uc3A:
26.0		 5lvnA-3uc3A:
29.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 3uc3 SERINE/THREONINE-PRO
TEIN KINASE SRK2I
(Arabidopsis
thaliana) 		4 / 8 ILE A  93
ILE A 312
ALA A 316
ILE A 313
 None
 0.76A 5mvmA-3uc3A:
2.9
5mvmB-3uc3A:
2.9		 5mvmA-3uc3A:
13.03
5mvmB-3uc3A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3uc3 SERINE/THREONINE-PRO
TEIN KINASE SRK2I
(Arabidopsis
thaliana) 		4 / 8 ASP A 200
ARG A 140
HIS A 133
ASP A 161
 None
 1.20A 6mn4C-3uc3A:
undetectable		 6mn4C-3uc3A:
21.29