SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uca'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		5 / 12 ASP A  91
SER A  87
THR A 188
ARG A  55
ASP A 228
 None
 1.44A 1dy4A-3ucaA:
undetectable		 1dy4A-3ucaA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		4 / 7 ASP A 157
GLY A 161
GLY A 162
TYR A 182
 None
 0.90A 1ekjE-3ucaA:
undetectable
1ekjF-3ucaA:
undetectable		 1ekjE-3ucaA:
21.71
1ekjF-3ucaA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		5 / 12 ILE A 192
LEU A 292
LEU A 289
HIS A  84
ILE A  57
 None
 1.22A 1fmlB-3ucaA:
undetectable		 1fmlB-3ucaA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		4 / 7 ASP A  41
LEU A 124
SER A  46
ASN A 108
 None
 1.12A 1ig3A-3ucaA:
undetectable
1ig3B-3ucaA:
undetectable		 1ig3A-3ucaA:
23.19
1ig3B-3ucaA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		5 / 12 ILE A  54
ALA A 194
GLY A 221
GLY A 189
LEU A 220
 None
 1.00A 1rjdA-3ucaA:
undetectable		 1rjdA-3ucaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		5 / 12 ILE A  54
ALA A 194
GLY A 221
GLY A 189
LEU A 220
 None
 0.98A 1rjdB-3ucaA:
undetectable		 1rjdB-3ucaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		5 / 12 ILE A  54
ALA A 194
GLY A 221
GLY A 189
LEU A 220
 None
 0.98A 1rjdC-3ucaA:
undetectable		 1rjdC-3ucaA:
21.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		5 / 11 SER A  87
LEU A  88
ASP A  97
ARG A 102
THR A 188
 None
 0.57A 1rqjA-3ucaA:
34.9		 1rqjA-3ucaA:
35.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		5 / 11 SER A  87
LEU A  88
ASP A  97
ARG A 102
GLN A 163
 None
 0.89A 1rqjB-3ucaA:
34.9		 1rqjB-3ucaA:
35.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		5 / 11 SER A  87
LEU A  88
ASP A  97
ARG A 102
THR A 188
 None
 0.54A 1rqjB-3ucaA:
34.9		 1rqjB-3ucaA:
35.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EZ7_A_DHIA301_0
(CARBONIC ANHYDRASE 2)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		4 / 6 HIS A 109
ASN A  98
THR A 107
PRO A 106
 None
 1.32A 2ez7A-3ucaA:
undetectable		 2ez7A-3ucaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		5 / 12 LEU A  88
ASP A  97
ARG A 102
GLN A 163
THR A 188
 None
 0.49A 2f94F-3ucaA:
26.3		 2f94F-3ucaA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		5 / 10 LEU A  88
ASP A  97
ARG A 102
LYS A 187
THR A 188
 None
 1.34A 2f9kF-3ucaA:
26.3		 2f9kF-3ucaA:
24.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		5 / 9 LEU A  88
ASP A  97
ARG A 102
LYS A 187
THR A 188
 None
 1.23A 2o1oA-3ucaA:
24.6		 2o1oA-3ucaA:
30.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		4 / 7 ILE A  54
LEU A 220
GLY A 221
PHE A 224
 None
 0.76A 2tsrA-3ucaA:
undetectable		 2tsrA-3ucaA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		5 / 12 ILE A 196
GLY A 199
ALA A 203
ALA A  77
ILE A  65
 None
 1.06A 3jayA-3ucaA:
undetectable		 3jayA-3ucaA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		5 / 10 LEU A  88
ASP A  97
ARG A 102
LYS A 187
THR A 188
 None
 1.33A 3n46F-3ucaA:
26.2		 3n46F-3ucaA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		4 / 7 ILE A  54
LEU A 220
GLY A 221
PHE A 224
 None
 0.75A 4iqqB-3ucaA:
undetectable		 4iqqB-3ucaA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		5 / 10 LEU A  88
ASP A  97
ARG A 102
LYS A 187
THR A 188
 None
 1.33A 4kq5A-3ucaA:
26.1		 4kq5A-3ucaA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		5 / 12 LEU A  88
ASP A  97
ARG A 102
GLN A 163
THR A 188
 None
 0.51A 4ng6A-3ucaA:
26.8		 4ng6A-3ucaA:
25.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		6 / 8 SER A  87
LEU A  88
ASP A  97
ARG A 102
MET A 159
GLN A 163
 None
 0.42A 4umjA-3ucaA:
34.8		 4umjA-3ucaA:
38.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		5 / 9 SER A  87
LEU A  88
ASP A  91
GLN A 163
THR A 188
 None
 1.10A 4umjB-3ucaA:
35.1		 4umjB-3ucaA:
38.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		7 / 9 SER A  87
LEU A  88
ASP A  97
ARG A 102
MET A 159
GLN A 163
THR A 188
 None
 0.53A 4umjB-3ucaA:
35.1		 4umjB-3ucaA:
38.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		4 / 6 HIS A  84
GLY A  51
GLU A  81
ARG A  53
 None
 1.09A 4zbqA-3ucaA:
4.1		 4zbqA-3ucaA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		5 / 12 PHE A 216
LEU A 220
ILE A  54
SER A  62
HIS A  84
 None
 1.46A 5h1eA-3ucaA:
undetectable		 5h1eA-3ucaA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		4 / 7 ILE A  54
LEU A 220
GLY A 221
PHE A 224
 None
 0.64A 5h3aB-3ucaA:
undetectable		 5h3aB-3ucaA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		3 / 3 TYR A  66
TYR A 135
SER A 142
 None
 0.98A 5iktB-3ucaA:
undetectable		 5iktB-3ucaA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		4 / 8 LEU A 177
PHE A 259
GLU A 263
ILE A 226
 None
 0.84A 5mzjA-3ucaA:
3.4		 5mzjA-3ucaA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		4 / 7 ILE A  54
LEU A 220
GLY A 221
PHE A 224
 None
 0.79A 5nooA-3ucaA:
undetectable		 5nooA-3ucaA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		4 / 7 ILE A  54
LEU A 220
GLY A 221
PHE A 224
 None
 0.75A 5nooB-3ucaA:
undetectable		 5nooB-3ucaA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		4 / 7 LEU A  88
ASP A  97
ARG A 102
GLN A 163
 None
 0.73A 6g31D-3ucaA:
21.9		 6g31D-3ucaA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		4 / 6 LEU A  88
ASP A  97
ARG A 102
GLN A 163
 None
 0.81A 6g31J-3ucaA:
22.6		 6g31J-3ucaA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 3uca GERANYLTRANSTRANSFER
ASE
(Clostridium
perfringens) 		4 / 5 ASN A 253
GLY A 189
HIS A 184
ASP A 229
 None
 0.90A 6gh9A-3ucaA:
undetectable		 6gh9A-3ucaA:
13.58